Cs2CO3-promoted methylene insertion into disulfide bonds using acetone as a methylene source?

Organic & Biomolecular Chemistry Pub Date: 2018-05-16 DOI: 10.1039/C8OB00877A

Abstract

An efficient halogen-free Cs2CO3-promoted methylene insertion into disulfide bonds has been achieved using acetone as a methylene source under mild conditions. This method provides a convenient and practical route to dithioacetals in up to 96% yield with good functional group compatibility.

Graphical abstract: Cs2CO3-promoted methylene insertion into disulfide bonds using acetone as a methylene source
Recommended Literature