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  Wenfan Chen,Qiuping Ding,Ziyi Nie,Yiyuan Peng RSC Adv. 2016 6 48767
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• 4. Synthesis of 2-trifluoromethylated quinolines from CF3-alkenes
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinolines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives

Introduction to 2-(Trifluoromethyl)quinoline (CAS No: 347-42-2)

2-(Trifluoromethyl)quinoline, also known by its CAS number 347-42-2, is a heterocyclic aromatic compound that has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science. This compound is characterized by its quinoline skeleton, which consists of a benzene ring fused with a pyridine ring, and the presence of a trifluoromethyl group at the 2-position. The trifluoromethyl substituent introduces unique electronic and steric properties, making this compound highly versatile for various applications.

The synthesis of 2-(Trifluoromethyl)quinoline has been extensively studied, with researchers exploring various methodologies to optimize its production. Recent advancements in catalytic processes and green chemistry have enabled more efficient and environmentally friendly routes for its synthesis. For instance, the use of palladium-catalyzed coupling reactions has been reported to significantly enhance the yield and purity of this compound. Such innovations not only address sustainability concerns but also pave the way for large-scale industrial production.

In terms of chemical properties, 2-(Trifluoromethyl)quinoline exhibits remarkable stability under standard conditions, thanks to the aromaticity of its quinoline core. The trifluoromethyl group contributes to its lipophilicity, which is a desirable trait in drug design as it facilitates membrane permeability. Recent studies have highlighted the compound's potential as a building block for constructing bioactive molecules. For example, researchers have utilized it as a precursor for synthesizing novel antitumor agents with improved efficacy and reduced toxicity compared to conventional chemotherapy drugs.

The electronic properties of 2-(Trifluoromethyl)quinoline make it an attractive candidate for applications in optoelectronics and photovoltaics. Its conjugated π-system allows for efficient charge transport and light absorption, which are critical for devices such as organic light-emitting diodes (OLEDs) and solar cells. Recent breakthroughs in materials science have demonstrated that incorporating this compound into polymer blends can significantly enhance the performance of these devices. For instance, studies published in high-impact journals such as Nature Materials and Advanced Functional Materials have shown that films made from these blends exhibit superior charge carrier mobility and photostability.

Beyond its chemical applications, 2-(Trifluoromethyl)quinoline has also found utility in analytical chemistry as a chiral selector in chromatographic separations. Its ability to interact selectively with enantiomers makes it valuable for resolving racemic mixtures into their individual enantiomers. This property is particularly useful in the pharmaceutical industry, where enantiopure compounds are often required for drug development. Recent advancements in chiral recognition mechanisms have further enhanced the efficiency of such separations, making this compound an indispensable tool in modern analytical techniques.

In conclusion, 2-(Trifluoromethyl)quinoline (CAS No: 347-42-2) stands out as a multifaceted compound with diverse applications across various scientific disciplines. Its unique structural features and versatile properties continue to drive innovative research and development efforts. As scientific understanding advances, particularly in areas such as green chemistry and materials science, this compound is poised to play an even more significant role in shaping future technologies and therapeutic interventions.

• 51310-54-4(2-(Trifluoromethyl)-1H-indole)
• 1860-47-5(Quinoline,6-methyl-2-(trifluoromethyl)-)
• 176722-64-8(6-bromo-2-(trifluoromethyl)quinoline)
• 176722-70-6(7-Chloro-2-(trifluoromethyl)quinoline)
• 916914-03-9(2-(Difluoromethyl)-1H-indole)
• 1860-46-4(Quinoline,8-methyl-2-(trifluoromethyl)-)
• 176722-74-0(7-Methyl-2-(trifluoromethyl)quinoline)
• 1190315-48-0(6-(Trifluoromethyl)-1H-pyrrolo[3,2-c]pyridine)
• 76068-41-2(4-methyl-2-(trifluoromethyl)quinoline)
• 368-48-9(2-(Trifluoromethyl)pyridine)