Production Method 1

3198-32-1

96946-43-9

Reaction Conditions

Reference

Biodegradable neuromuscular blocking agents. Part 6. Stereochemical studies on atracurium and related polyalkylene di-esters

Stenlake, John B.; Waigh, Roger D.; Dewar, George H.; Dhar, Nirmal C.; Hughes, Roy; et al, European Journal of Medicinal Chemistry, 1984, 19(5), 441-50

Production Method 2

80-18-2

144-62-7

64228-84-8

3198-32-1

96946-41-7

Reaction Conditions

1.1 Reagents: Sodium carbonate Solvents: Water ;  pH 7, rt
1.2 overnight, rt

Reference

Process for preparation of atracurium besylate with improved isomeric ratio

Anonymous, IP.com Journal, 2009, ,

Production Method 3

3198-32-1

96946-41-7

Reaction Conditions

Reference

Cisatracurium besylate. 51W89. Nimbex. Nondepolarizing neuromuscular blocking agent

Mealy, N.; Castaner, J., Drugs of the Future, 1996, 21(1), 14-19

Production Method 4

3198-32-1

96946-41-7

Reaction Conditions

Reference

Biodegradable neuromuscular blocking agents. Part 6. Stereochemical studies on atracurium and related polyalkylene di-esters

Stenlake, John B.; Waigh, Roger D.; Dewar, George H.; Dhar, Nirmal C.; Hughes, Roy; et al, European Journal of Medicinal Chemistry, 1984, 19(5), 441-50

Production Method 5

3198-32-1

96946-45-1

Reaction Conditions

Reference

Biodegradable neuromuscular blocking agents. Part 6. Stereochemical studies on atracurium and related polyalkylene di-esters

Stenlake, John B.; Waigh, Roger D.; Dewar, George H.; Dhar, Nirmal C.; Hughes, Roy; et al, European Journal of Medicinal Chemistry, 1984, 19(5), 441-50

Benzenesulfonic acid,ion(1-) Raw materials

• Methyl benzenesulfonate
• Oxalic acid
• (R,R)-N,N'-Didemethyl Atracurium

Benzenesulfonic acid,ion(1-) Preparation Products

• Isoquinolinium, 2,2'-[1,5- pentanediylbis[oxy(3-oxo-3,1- propanediyl)]]bis[1-[(3,4- dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, [1R-[1α,2β(1'R*,2'S*)]]- (96946-45-1)
• Benzenesulfonic acid,ion(1-) (3198-32-1)
• Atracurium Impurity 21 (96946-43-9)
• Isoquinolinium,2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-,(1R,1'R,2R,2'R)- (96946-41-7)

• 1. The effect of the shape of the mesogenic group on the structure and phase behavior of 2,3,4-tris(dodecyloxy)benzenesulfonates with alkaline cations
  Maxim A. Shcherbina,Artem V. Bakirov,Andrei N. Yakunin,Uwe Beginn,Linglong Yan,Martin M?ller,Sergei N. Chvalun Soft Matter 2014 10 1746
• 2. Very efficient conversion of glucose to 5-hydroxymethylfurfural in DBU-based ionic liquids with benzenesulfonate anion
  Lingqiao Wu,Jinliang Song,Binbin Zhang,Baowen Zhou,Huacong Zhou,Honglei Fan,Yingying Yang,Buxing Han Green Chem. 2014 16 3935
• 3. Molecular dynamics and the translational–rotational coupling of an ionically conducting glass-former: amlodipine besylate
  Safna Hussan K. P,Mohamed Shahin Thayyil,S. K. Deshpande,Jinitha T. V,Manoj K,K. L. Ngai RSC Adv. 2018 8 20630
• 4. Ab initio study of the methylsulfonate and phenylsulfonate anions
  Isabel Rozas,Donald F. Weaver J. Chem. Soc. Perkin Trans. 2 1996 461
• 5. Supramolecular forces and their interplay in stabilizing complexes of organic anions: tuning binding selectivity in water
  Matteo Savastano,Carla Bazzicalupi,Celeste García-Gallarín,Maria Dolores López de la Torre,Antonio Bianchi,Manuel Melguizo Org. Chem. Front. 2019 6 75

• 581-75-9(Naphthalene-2,6-disulfonic acid)
• 26158-00-9(Benzenesulfonic acid monohydrate)
• 76530-12-6(Naphthalene-2-sulfonic acid hydrate)
• 211366-30-2(1,5-Naphthalenedisulfonic acid tetrahydrate)
• 81-04-9(1,5-Naphthalenedisulfonic acid)
• 19402-64-3(Ammonium Benzenesulfonate)
• 120-18-3(2-Naphthalene Sulfonic Acid)
• 98-11-3(Phenylsulfonic Acid)
• 85-47-2(Naphthalene-1-sulfonic Acid (Technical Grade))
• 92-41-1(Naphthalene-2,7-disulfonic acid)