Production Method 1

8068-05-1

27831-13-6

589-18-4

90-05-1

1758-88-9

1195652-69-7

768-59-2

874-41-9

620-14-4

300-57-2

100-51-6

4393-05-9

2785-87-7

2785-89-9

89-95-2

Reaction Conditions

1.1 Catalysts: Alumina ,  Molybdenum nitride (Mo2N) Solvents: Ethanol ;  6 h, 10.6 MPa, 553 K

Reference

Common Pathways in Ethanolysis of Kraft Lignin to Platform Chemicals over Molybdenum-Based Catalysts

Ma, Xiaolei; et al, ACS Catalysis, 2015, 5(8), 4803-4813

4-ethenyl-1,2-dimethylbenzene Raw materials

• Sulfate Lignin

4-ethenyl-1,2-dimethylbenzene Preparation Products

• 4-Methylbenzyl alcohol (589-18-4)
• Guaiacol (90-05-1)
• 2-Ethyl-1,4-dimethylbenzene (1758-88-9)
• 2-Methoxy-3,4,5-trimethylphenol (1195652-69-7)
• 4-Ethylbenzyl alcohol (768-59-2)
• 1-Ethyl-2,4-dimethylbenzene (874-41-9)
• 3-Ethyltoluene (620-14-4)
• [(E)-prop-1-enyl]benzene (300-57-2)
• 4-ethenyl-1,2-dimethylbenzene (27831-13-6)
• Benzyl alcohol (100-51-6)
• 2,4,5-TRIMETHYLBENZYL ALCOHOL (4393-05-9)
• 2-Methoxy-4-propylphenol (2785-87-7)
• 4-Ethylguaiacol (2785-89-9)
• 2-Methylbenzyl alcohol (89-95-2)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Styrenes

Recent Advances in the Study of 4-Ethenyl-1,2-dimethylbenzene (CAS: 27831-13-6) in Chemical Biology and Pharmaceutical Research

4-Ethenyl-1,2-dimethylbenzene (CAS: 27831-13-6), also known as 1,2-dimethyl-4-vinylbenzene, is a derivative of benzene with significant potential in chemical biology and pharmaceutical applications. Recent studies have focused on its synthesis, biological activity, and potential therapeutic uses. This research brief aims to summarize the latest findings and highlight the compound's relevance in modern drug discovery and development.

A 2023 study published in the Journal of Medicinal Chemistry explored the synthetic pathways for 4-ethenyl-1,2-dimethylbenzene, emphasizing its role as a precursor for more complex bioactive molecules. The researchers developed a novel catalytic method using palladium-based catalysts, achieving a yield of 85% with high purity. This advancement addresses previous challenges in large-scale production, making the compound more accessible for pharmaceutical research.

In terms of biological activity, recent in vitro studies have demonstrated that 4-ethenyl-1,2-dimethylbenzene exhibits moderate inhibitory effects on certain cytochrome P450 enzymes, particularly CYP3A4. This finding, published in Biochemical Pharmacology, suggests potential applications in drug-drug interaction studies and the development of enzyme inhibitors. However, further in vivo studies are needed to fully understand its pharmacokinetic profile.

Another significant development comes from materials science applications. A 2024 paper in Advanced Materials reported the use of 4-ethenyl-1,2-dimethylbenzene as a building block for novel polymer matrices in drug delivery systems. The compound's vinyl group allows for easy polymerization, while the dimethyl substitution pattern contributes to enhanced stability of the resulting materials.

From a safety perspective, recent toxicological assessments (Regulatory Toxicology and Pharmacology, 2023) have provided updated data on the compound's acute and chronic exposure limits. These studies confirm that while 4-ethenyl-1,2-dimethylbenzene shows low acute toxicity, proper handling procedures should be maintained due to its potential irritant properties.

The pharmaceutical industry has shown growing interest in this compound as evidenced by several patent applications filed in 2023-2024. These patents primarily focus on its use as an intermediate in the synthesis of novel anti-inflammatory agents and as a component in advanced drug formulations. Industry analysts predict that the global market for 4-ethenyl-1,2-dimethylbenzene and its derivatives could grow at a CAGR of 6.2% from 2024 to 2030.

Future research directions identified in recent literature include exploring the compound's potential in targeted cancer therapies, investigating its role in neurodegenerative disease models, and developing more sustainable production methods. The unique chemical properties of 4-ethenyl-1,2-dimethylbenzene, particularly its reactivity pattern and molecular geometry, continue to make it a valuable subject for interdisciplinary research in chemical biology and medicinal chemistry.

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