Production Method 1

24242-79-3

80826-86-4

Reaction Conditions

1.1 Reagents: Iodine ,  Oxygen Catalysts: Nitric acid Solvents: 1,2-Dichloroethane ,  Water ;  0.5 h, 0.1 MPa, 20 °C
1.2 Reagents: Sodium sulfite Solvents: Water

Reference

Metal-free catalytic aerobic oxyiodination of organic molecules activated by HNO3

Wang, Kaiyang; Wang, Xinliang; Liang, Xinmiao, Jingxi Huagong, 2009, 26(10), 1032-1035

Production Method 2

24242-79-3

80826-86-4

Reaction Conditions

1.1 Reagents: tert-Butyl hydroperoxide ,  Potassium iodide Solvents: Methanol ,  Water ;  30 min, rt; 8 h, rt
1.2 Reagents: Sodium thiosulfate

Reference

Mild and efficient oxy-iodination of alkynes and phenols with potassium iodide and tert-butyl hydroperoxide

Rajender Reddy, K.; Venkateshwar, M.; Uma Maheswari, C.; Santhosh Kumar, P., Tetrahedron Letters, 2010, 51(16), 2170-2173

Production Method 3

24242-79-3

80826-86-4

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Potassium iodide ,  Hydrogen peroxide Catalysts: Sodium dodecyl sulfate Solvents: Water ;  2 h, 303 °C
1.2 Reagents: Hexadecyltrimethylammonium bromide Solvents: Water

Reference

Selectivity enhancement of aromatic halogenation reactions at the micellar interface: effect of highly ionic media

Samant, Bhupesh S.; Bhagwat, Sunil S., Monatshefte fuer Chemie, 2012, 143(7), 1039-1044

Production Method 4

24242-79-3

80826-86-4

Reaction Conditions

1.1 Reagents: Hydrogen peroxide ,  Ammonium iodide Solvents: Acetic acid ,  Water ;  6 h, rt

Reference

Eco-friendly oxyiodination of aromatic compounds using ammonium iodide and hydrogen peroxide

Narender, N.; Reddy, K. Suresh Kumar; Mohan, K. V. V. Krishna; Kulkarni, S. J., Tetrahedron Letters, 2007, 48(35), 6124-6128

2-iodo-3,5-dimethyl-phenol Preparation Products

• 3,5-Dimethyl-4-iodophenol (80826-86-4)
• 2-iodo-3,5-dimethyl-phenol (24242-79-3)

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