Production Method 1

9005-53-2

2416-94-6

88-60-8

87-85-4

2219-78-5

1758-88-9

13037-79-1

15181-13-2

13632-94-5

876-20-0

622-96-8

1687-64-5

527-84-4

700-12-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium ,  Chromium chloride (CrCl3) Solvents: Methanol ;  4 h, 2 MPa, 280 °C

Reference

Insight into the solvent, temperature and time effects on the hydrogenolysis of hydrolyzed lignin

Shu, Riyang; Zhang, Qi; Ma, Longlong; Xu, Ying; Chen, Pengru; et al, Bioresource Technology, 2016, 221, 568-575

Production Method 2

8068-05-1

2416-94-6

831-00-5

88-32-4

2219-78-5

527-18-4

65565-33-5

13037-79-1

77879-82-4

33963-27-8

Reaction Conditions

1.1 Catalysts: Sodium hydroxide Solvents: Methanol ;  7 h, 220 °C

Reference

Thermochemical lignin depolymerization and conversion to aromatics in subcritical methanol: effects of catalytic conditions

Singh, Sunit Kumar; et al, New Journal of Chemistry, 2016, 40(4), 3677-3685

2,3,6-Trimethylphenol Raw materials

• Lignin
• Sulfate Lignin

2,3,6-Trimethylphenol Preparation Products

• 2-tert-butyl-5-methylphenol (88-60-8)
• Hexamethylbenzene (87-85-4)
• 2',4'-Dimethoxypropiophenone (831-00-5)
• 2-tert-Butyl-4-hydroxyanisole (88-32-4)
• Phenol,2-ethyl-4,5-dimethyl- (2219-78-5)
• Tetramethylhydroquinone (527-18-4)
• 2-Ethyl-1,4-dimethylbenzene (1758-88-9)
• 1-Naphthalenecarboxaldehyde, 4,6-dimethoxy- (65565-33-5)
• Phenol,2-(1,1-dimethylethyl)-3-methyl- (13037-79-1)
• Benzene,1-ethyl-3,5-bis(1-methylethyl)- (15181-13-2)
• Benzene,1,4-diethyl-2-methyl- (13632-94-5)
• 2-methoxy-4-methyl-6-(prop-2-en-1-yl)phenol (77879-82-4)
• 2-Phenylethyl-1,1,2,2-d4-amine (876-20-0)
• 4-Ethoxy-3-methoxytoluene (33963-27-8)
• 4-Ethyltoluene (622-96-8)
• 2-Ethyl-6-methylphenol (1687-64-5)
• o-Cymene (527-84-4)
• 1,2,3,4,5-pentamethylbenzene (700-12-9)

• 1. Polyoxometalate-based supramolecular porous frameworks with dual-active centers towards highly efficient synthesis of functionalized p-benzoquinones
  Shenzhen Chang,Yanhong Chen,Haiyan An,Qingshan Zhu,Huiyun Luo,Yaohui Huang Green Chem. 2021 23 8591
• 2. Thermochemical lignin depolymerization and conversion to aromatics in subcritical methanol: effects of catalytic conditions
  Sunit Kumar Singh,Kunal Nandeshwar,Jayant D. Ekhe New J. Chem. 2016 40 3677
• 3. Deoxyalkylation of guaiacol using haggite structured V4O6(OH)4
  Fei Yan,Zhe Wen,Kai Wu,Kai Cui,Fuhang Mai,Zewei Ma,Yushuai Sang,Yunfei Bai,Hong Chen,Yongdan Li Catal. Sci. Technol. 2019 9 1922
• 4. Deoxyalkylation of guaiacol using haggite structured V4O6(OH)4
  Fei Yan,Zhe Wen,Kai Wu,Kai Cui,Fuhang Mai,Zewei Ma,Yushuai Sang,Yunfei Bai,Hong Chen,Yongdan Li Catal. Sci. Technol. 2019 9 1922
• 5. Insights into the surface chemistry and electronic properties of sp2 and sp3-hybridized nanocarbon materials for catalysis
  Yangming Lin,Zhenbao Feng,Linhui Yu,Qinging Gu,Shuchang Wu,Dang Sheng Su Chem. Commun. 2017 53 4834

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenols Ortho cresols
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenols Cresols Ortho cresols
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

Comprehensive Guide to 2,3,6-Trimethylphenol (CAS No. 2416-94-6): Properties, Applications, and Industry Trends

2,3,6-Trimethylphenol (CAS No. 2416-94-6) is a versatile organic compound widely used in industrial and research applications. This trimethylated phenol derivative is known for its unique chemical structure, which contributes to its reactivity and utility in various synthetic processes. With the growing demand for specialty chemicals, this compound has garnered significant attention in fields such as pharmaceutical intermediates, flavor and fragrance production, and polymer stabilization.

The molecular formula of 2,3,6-Trimethylphenol is C₉H₁₂O, featuring three methyl groups attached to a phenol ring. This structure enhances its solubility in organic solvents while retaining phenolic properties like acidity and hydrogen bonding. Researchers often explore its role in oxidation reactions and as a precursor for high-performance resins. Recent studies highlight its potential in green chemistry applications, aligning with the global shift toward sustainable manufacturing.

One of the most searched questions about CAS No. 2416-94-6 is its safety profile and environmental impact. While not classified as hazardous under standard regulations, proper handling protocols are recommended due to its phenolic nature. Industry professionals frequently inquire about its synthesis methods, with newer catalytic processes reducing energy consumption—a hot topic in circular economy discussions. The compound’s stability under heat also makes it relevant for thermal material research.

In the flavor and fragrance industry, 2,3,6-Trimethylphenol serves as a building block for smoky or woody notes, catering to consumer demand for natural-inspired aromas. Its derivatives appear in food-grade antioxidants, addressing clean-label trends. Meanwhile, material scientists value its electron-donating methyl groups for designing UV-resistant coatings—a growing niche due to increased solar panel and automotive coating demands.

Analytical techniques like GC-MS and HPLC are commonly employed to verify the purity of 2416-94-6, especially for pharmaceutical applications where impurity thresholds are critical. The compound’s chromatographic behavior is frequently discussed in academic forums, with optimized methods being shared among analytical chemistry communities. This aligns with the broader industry focus on quality control automation and digital chromatography solutions.

Market analysts note rising demand for trimethylphenol isomers in Asia-Pacific regions, driven by expanding agrochemical formulations and electronic material production. Patent filings reveal innovative uses in flexible electronics and biodegradable plastics, connecting this classic compound to cutting-edge technologies. Such developments make 2,3,6-Trimethylphenol a compelling case study in chemical repurposing strategies.

Storage recommendations for CAS 2416-94-6 typically emphasize protection from light and moisture, with nitrogen blanketing suggested for large-scale preservation. These protocols resonate with current smart storage trends incorporating IoT sensors for real-time quality monitoring. Suppliers increasingly provide COA documentation with detailed isotopic purity data, reflecting heightened quality expectations in regulated industries.

Future research directions may explore 2,3,6-Trimethylphenol’s role in carbon capture materials or battery electrolyte additives, areas gaining traction in energy transition debates. Its structural analogs are already being screened for biological activity, tapping into the computational chemistry boom. As industries prioritize multifunctional additives, this compound’s balanced properties position it for continued relevance across evolving technological landscapes.

• 1300-71-6(Dimethylphenol)
• 608-43-5(2,3-Xylohydroquinone)
• 2819-86-5(Phenol,2,3,4,5,6-pentamethyl-)
• 2785-76-4(3,4-dimethylbenzene-1,2-diol)
• 496-78-6(2,4,5-trimethylphenol)
• 362049-46-5(2,3,5-Trimethylphenol-d11)
• 26998-80-1(Phenol, trimethyl-)
• 1321-28-4(1,4-Benzenediol,dimethyl-)
• 700-13-0(Trimethylhydroquinone)
• 697-82-5(2,3,5-Trimethyphenol)