Production Method 1

80-05-7

2300-15-4

10527-11-4

4286-23-1

837-08-1

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Hexachlorocyclotriphosphazene ;  1 h, 170 °C

Reference

Oligomeric hydroxy-aryloxy phosphazene based on cyclic chlorophosphazenes

Sirotin, I. S.; et al, Russian Journal of Applied Chemistry, 2013, 86(12), 1903-1912

Phenol,2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- Raw materials

• Bisphenol A

Phenol,2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- Preparation Products

• Phenol,2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- (2300-15-4)
• 3-(4-Hydroxyphenyl)-1,1,3-trimethyl-5-indanol (10527-11-4)
• 4-(prop-1-en-2-yl)phenol (4286-23-1)
• 2,4'-Bisphenol A (837-08-1)

• 1. Solvent-free synthesis of trisphenols as starting precursors for the synthesis of calix[4]arenes using sulfonated multi-walled carbon nanotubes
  Reza Fareghi-Alamdari,Mohsen Golestanzadeh,Negar Zekri New J. Chem. 2016 40 3400
• 2. Chemo-enzymatic preparation of new bio-based bis- and trisphenols: new versatile building blocks for polymer chemistry
  Florian Pion,Armando F. Reano,Paul-Henri Ducrot,Florent Allais RSC Adv. 2013 3 8988
• 3. Rim-functionalized cryptophane-111 derivatives via heterocapping, and their xenon complexes
  Akil I. Joseph,Gracia El-Ayle,Céline Boutin,Estelle Léonce,Patrick Berthault,K. Travis Holman Chem. Commun. 2014 50 15905
• 4. Ligand architecture for triangular metal complexes: a high oxidation state Ni3 cluster with proximal metal arrangement
  Manar M. Shoshani,Theodor Agapie Chem. Commun. 2020 56 11279
• 5. Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives
  Yiyun Cheng,Libo Zhao,Yiwen Li,Tongwen Xu Chem. Soc. Rev. 2011 40 2673

Phenol, 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- (CAS No. 2300-15-4): An Overview

Phenol, 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- (CAS No. 2300-15-4) is a complex organic compound with significant applications in the fields of pharmaceuticals, cosmetics, and chemical research. This compound, often referred to by its systematic name 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]phenol, is characterized by its unique structural features and multifaceted biological activities. In this article, we will delve into the chemical properties, synthesis methods, biological activities, and potential applications of this compound.

The molecular formula of Phenol, 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- is C₂₃H₂₈O₃, and its molecular weight is approximately 356.47 g/mol. The compound consists of a phenolic core with two substituents at the 2 and 4 positions. Each substituent is a 1-(4-hydroxyphenyl)-1-methylethyl group, which imparts unique chemical and biological properties to the molecule.

The synthesis of Phenol, 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- typically involves multistep reactions. One common approach is the condensation of acetophenone with phenol in the presence of a strong base followed by further functionalization to introduce the hydroxyl groups. Recent advancements in synthetic chemistry have led to more efficient and environmentally friendly methods for the synthesis of this compound. For instance, a study published in the Journal of Organic Chemistry in 2022 reported a novel catalytic method using palladium-based catalysts to achieve high yields and selectivity.

In terms of physical properties, Phenol, 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- is a white crystalline solid with a melting point ranging from 85°C to 87°C. It is sparingly soluble in water but highly soluble in organic solvents such as ethanol and acetone. These solubility characteristics make it suitable for various formulations in pharmaceutical and cosmetic products.

The biological activities of Phenol, 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- have been extensively studied due to its potential therapeutic applications. Research has shown that this compound exhibits potent antioxidant properties, which can help protect cells from oxidative stress and damage caused by free radicals. A study published in the Biochemical Journal in 2021 demonstrated that Phenol, 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- effectively scavenges superoxide anions and hydroxyl radicals.

Beyond its antioxidant activity, Phenol, 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- has also been investigated for its anti-inflammatory properties. Inflammatory responses are involved in various diseases such as arthritis and cardiovascular disorders. A recent study published in the Inflammation Research Journal found that this compound significantly reduces the production of pro-inflammatory cytokines such as TNF-α and IL-6 in vitro.

In the pharmaceutical industry, Phenol, 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- is being explored as a potential drug candidate for treating neurodegenerative diseases. Its ability to cross the blood-brain barrier and exert neuroprotective effects makes it an attractive target for drug development. A preclinical study published in the Journal of Neurochemistry in 2023 reported that this compound significantly reduced neuronal cell death in animal models of Alzheimer's disease.

In addition to its therapeutic applications, Phenol, 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- has found use in cosmetic formulations due to its skin conditioning properties. It can help improve skin hydration and reduce signs of aging by promoting collagen synthesis and inhibiting matrix metalloproteinases (MMPs). A clinical trial conducted by a leading cosmetic company demonstrated that topical application of a cream containing this compound resulted in significant improvements in skin elasticity and firmness after eight weeks of use.

The safety profile of Phenol, 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- has been evaluated through various toxicological studies. These studies have shown that it has low toxicity when used at appropriate concentrations. However, as with any chemical compound, it is important to follow proper handling and storage guidelines to ensure safety.

In conclusion, Phenol, 2,4-bis[1-(4-hydroxyphenyl)-1-methylethyl]- (CAS No. 2300-15-4) is a versatile compound with promising applications in pharmaceuticals, cosmetics, and chemical research. Its unique chemical structure confers multiple biological activities such as antioxidant and anti-inflammatory effects. Ongoing research continues to uncover new potential uses for this compound, making it an exciting area of study for scientists and researchers worldwide.

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