Cas no 22888-70-6 (Silybin A)

Silybin A is a naturally occurring flavonoid compound exhibiting potent antioxidant properties and hepatoprotective effects. Its key advantages lie in its ability to scavenge free radicals, inhibit lipid peroxidation, and modulate cellular response to oxidative stress, thereby protecting against liver damage and promoting overall cellular well-being.
Silybin A structure
Silybin A structure
Product Name:Silybin A
CAS No:22888-70-6
MF:C25H22O10
MW:482.436188220978
MDL:MFCD00872186
CID:52163
PubChem ID:329751097
Update Time:2025-08-26

Silybin A Chemical and Physical Properties

Names and Identifiers

    • silymarin
    • Silibinin
    • Silybin
    • silymarin group
    • 2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxin
    • Silybum marianum
    • Silybum Extract
    • PRINCIPAL COMPONENT OF SILYMARINE
    • SILYBIN (A and B)(P) PrintBack
    • Silybin A
    • Silybin(Mixture A&B)
    • 7c3mt
    • flavobin
    • Silibinin A
    • silliver
    • silybine
    • SILYBININ
    • Silymarin I
    • Silymrin
    • 4-Chromanone,3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxan-6-yl]-(8CI)
    • 4H-1-Benzopyran-4-one,2-[2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,[2R-[2a,3b,6(2R*,3R*)]]-
    • Silybin (7CI)
    • 1,4-Benzodioxin,4H-1-benzopyran-4-one deriv.
    • Silybinb1
    • Silybum substance E6
    • Silymarin MZ 80
    • Silymarine I
    • [ "" ]
    • Silibinine
    • Silibininum
    • Silibinina
    • Flavobin Spofa
    • Silibinin [INN]
    • Silymarine
    • Silibininum [INN-Latin]
    • Silibinine [INN-French]
    • Silibinina [INN-Spanish]
    • Legalon
    • Silimarin
    • Silibin
    • 33X338MNE4
    • Silibinin (INN)
    • NSC651520
    • C25H22O10
    • DSSTox_CID_6018
    • DSSTox_RID_77985
    • DSSTox_GSID_26018
    • (2R,3R)-3,5,7-trihydroxy-2-((2R,3R)-3
    • (-)-Silybin B
    • Silybin a1
    • Silybin b1
    • MLS006011786
    • MLSMR
    • Silybin B
    • SMR000058272
    • MLS000028529
    • Karsil
    • MDL： MFCD00872186
    • Inchi： 1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3
    • InChI Key： SEBFKMXJBCUCAI-UHFFFAOYSA-N
    • SMILES： COC1C(O)=CC=C(C2C(CO)OC3C(=CC(C4C(O)C(=O)C5C(=CC(=CC=5O)O)O4)=CC=3)O2)C=1

Computed Properties

  • Exact Mass: 482.12100
  • Monoisotopic Mass: 482.12129689 g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 5
  • Hydrogen Bond Acceptor Count: 10
  • Heavy Atom Count: 35
  • Rotatable Bond Count: 4
  • Complexity: 750
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 4
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 155
  • Surface Charge: 0
  • Tautomer Count: 117
  • XLogP3: 2.4
  • Molecular Weight: 482.4

Experimental Properties

  • Color/Form: Powder
  • Density: 1.5270
  • Melting Point: 164-174°C
  • Boiling Point: 793℃ at 760mmHg
  • Stability/Shelf Life: Stable. Incompatible with strong oxidizing agents, strong bases.
  • PSA: 155.14000
  • LogP: 2.36270
  • Merck: 13,8607
  • Specific Rotation: D20 +11° (c = 0.25 in acetone + alcohol)

Silybin A Security Information

  • Symbol: GHS07
  • Signal Word：Warning
  • Hazard Statement： H315,H319,H335
  • Warning Statement： P261,P305+P351+P338
  • Hazardous Material transportation number：3172
  • WGK Germany：3
  • Hazard Category Code： 36/37/38
  • Safety Instruction： S26-S37/39-S24/25-S22
  • RTECS：DJ2981770
  • Hazardous Material Identification： Xi
  • Risk Phrases：R36/37/38
  • Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month

Silybin A Customs Data

  • HS CODE：2932999099
  • Customs Data：

    China Customs Code:

    2932999099

    Overview:

    2932999099. Other heterocyclic compounds containing only oxygen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Silybin A Pricemore >>

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SHANG HAI BI DE YI YAO KE JI GU FEN Co., Ltd.
BD32750-5g
(2R,3R)-3,5,7-Trihydroxy-2-((2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one
 22888-70-6 98%
5g
 ￥323.0 2024-09-23
SHANG HAI BI DE YI YAO KE JI GU FEN Co., Ltd.
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(2R,3R)-3,5,7-Trihydroxy-2-((2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one
 22888-70-6 98%
10g
 ￥600 2021-08-03
SHANG HAI BI DE YI YAO KE JI GU FEN Co., Ltd.
BD32750-25g
(2R,3R)-3,5,7-Trihydroxy-2-((2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one
 22888-70-6 98%
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SHANG HAI TAO SHU Biotechnology Co., Ltd.
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 22888-70-6 98.06%
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 ￥194.00 2022-04-26

Silybin A Production Method

Production Method 1

Reaction Conditions
1.1C:1435939-45-9, S:Me2CO, 24 h, 45°C
Reference
Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture
By Gazak, Radek et al, Process Biochemistry (Oxford, 2013, 48(1), 184-189

Silybin A Raw materials

Silybin A Preparation Products

Silybin A Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:22888-70-6)Silybin A
Order Number:A816402
Stock Status:in Stock
Quantity:25g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 05:05
Price ($):174.0
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:22888-70-6)Silibinin(A+B)
Order Number:LE10266;LE1135
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:02
Price ($):discuss personally
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:22888-70-6)Silymarin
Order Number:sfd22703
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:39
Price ($):discuss personally
Hubei Cuiyuan Biotechnology Co.,Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:22888-70-6)Silymarin
Order Number:CRN0148
Stock Status:in stock
Quantity:5mg/20mg/50mg
Purity:≥98%
Pricing Information Last Updated:Friday, 14 March 2025 10:55
Price ($):

Silybin A Spectrogram

LC-MS
LC-MS
1H NMR 300 MHz DMSO
1H NMR
13C NMR
13C NMR

Silybin A Related Literature

Related Categories

22888-70-6 (Silybin A) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:22888-70-6)Silybin A
A816402
Purity:99%
Quantity:25g
Price ($):174.0
Email
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:22888-70-6)Silibinin(A+B)
LE10266;LE1135
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
Email