Cas no 72581-71-6 (Isosilybin)
Isosilybin Chemical and Physical Properties
Names and Identifiers
-
- Isosilybin
- 2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
- 4H-1-Benzopyran-4-one,2-[2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-
- Isosilybinin
- isosilibinin
- Isosilybin, mixture of isomers
- (3S)-3,5,7-Trihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin
- Silymarin (Silybin B)
- Silymarin - Silybin B
- Isosilybin (A + B mixture)
- HMS3651O20
- BCP13563
- s2358
- EBD2217055
- SW219354-1
- 581I716
- 2-[[2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin]-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
- 3,5,7-trihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1
- (2R,3R)-3,5,7-trihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
- CS-6233
- BDBM50595721
- CCG-269565
- AC-34989
- AKOS030573651
- DTXSID10858695
- CHEBI:80744
- SCHEMBL4653986
- Q27149797
- (2R,3R)-3,5,7-Trihydroxy-2-(2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one
- Q-100795
- s9250
- EX-A8002P
- 72581-71-6
- (2R,3R)-3,5,7-trihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-1-benzopyran-4-one
- CHEMBL5204643
- HY-N0779
- Z3247556409
- AKOS015902478
- CID 21723007
- 4H-1-Benzopyran-4-one, 2-(2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-
- CCG-269566
- SCHEMBL972938
- FT-0775412
- 42110-65-6
- 3,5,7-trihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one
- FT-0775413
- 3,5,7-Trihydroxy-2-(2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one
- BS-49236
- DA-54460
- Isosilybin(2R,3R)-3,5,7-trihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one; Isosilibinin
- 1ST158716
-
- MDL： MFCD09842608
- Inchi： 1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20?,23-,24?,25+/m0/s1
- InChI Key： FDQAOULAVFHKBX-DBMPWETRSA-N
- SMILES： O1C2C=C(C=CC=2OC(C2C=CC(=C(C=2)OC)O)C1CO)[C@@H]1[C@H](C(C2C(=CC(=CC=2O1)O)O)=O)O
Computed Properties
- Exact Mass: 482.12100
- Monoisotopic Mass: 482.12129689 g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 5
- Hydrogen Bond Acceptor Count: 10
- Heavy Atom Count: 35
- Rotatable Bond Count: 4
- Complexity: 750
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 4
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.4
- Topological Polar Surface Area: 155
- Molecular Weight: 482.4
Experimental Properties
- Color/Form: Powder
- Density: 1.5270
- Melting Point: 239-241°C
- Boiling Point: 793 °C at 760 mmHg
- Flash Point: 274.4 °C
- Refractive Index: 1.684
- Solubility: 77.36 mg/L @ 25 °C (est)
- PSA: 155.14000
- LogP: 2.36270
Isosilybin Security Information
- Hazardous Material transportation number：NONH for all modes of transport
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
Isosilybin Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | I115859-10mg |
Isosilybin |
72581-71-6 | ,≥98% | 10mg |
￥2781.90 | 2023-09-02 | |
| S e l l e c k ZHONG GUO | S9250-1mg |
Isosilybin |
72581-71-6 | 99.93% | 1mg |
￥1285.9 | 2023-09-15 | |
| HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI | BZP0966-20mg |
Isosilybin |
72581-71-6 | HPLC≥98% | HPLC≥98% |
詢價(jià) | 2021-07-04 | |
| Chemenu | CM154161-250mg |
(2R,3R)-3,5,7-trihydroxy-2-(2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one |
72581-71-6 | 97% | 250mg |
$1272 | 2021-06-09 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R032863-10mg |
Isosilybin |
72581-71-6 | 98%（） | 10mg |
￥3338 | 2024-05-21 | |
| ChemScence | CS-6233-5mg |
Isosilybin |
72581-71-6 | 98.08% | 5mg |
$85.0 | 2022-04-26 | |
| ChemScence | CS-6233-10mg |
Isosilybin |
72581-71-6 | 98.08% | 10mg |
$130.0 | 2022-04-26 | |
| ChemScence | CS-6233-25mg |
Isosilybin |
72581-71-6 | 98.08% | 25mg |
$280.0 | 2022-04-26 | |
| ChemScence | CS-6233-50mg |
Isosilybin |
72581-71-6 | 98.08% | 50mg |
$520.0 | 2022-04-26 | |
| ChemScence | CS-6233-100mg |
Isosilybin |
72581-71-6 | 98.08% | 100mg |
$930.0 | 2022-04-26 |
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Isosilybin Related Literature
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Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
-
Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
-
Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
-
Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
Related Categories
- Solvents and Organic Chemicals Organic Compounds Lignans, neolignans and related compounds Flavonolignans Flavonolignans
- Solvents and Organic Chemicals Organic Compounds Lignans, neolignans and related compounds Flavonolignans
- Flavonones
- Flavonoids
- Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients Standard Substances
Additional information on Isosilybin
Isosilybin: A Promising Phytochemical with Diverse Bioactive Properties
Isosilybin, also known by its CAS number 72581-71-6, is a bioactive compound that has garnered significant attention in the fields of pharmacology and natural product research. Derived from the milk thistle plant (Silybum marianum), isosilybin is a flavonolignan, a class of compounds known for their antioxidant and anti-inflammatory properties. This compound has been extensively studied for its potential therapeutic applications, particularly in the context of liver health, oxidative stress, and chronic diseases.
The chemical structure of isosilybin is closely related to that of silybin, another prominent constituent of milk thistle. Both compounds share similar pharmacological profiles, but isosilybin exhibits unique bioactivity that sets it apart. Recent studies have highlighted its ability to modulate cellular signaling pathways involved in inflammation and oxidative stress, making it a promising candidate for drug development.
In terms of biological activity, isosilybin has demonstrated potent antioxidant properties, which are crucial in combating oxidative stress—a key factor in the pathogenesis of numerous diseases, including cardiovascular disorders and neurodegenerative conditions. Research published in 2023 revealed that isosilybin significantly reduces reactive oxygen species (ROS) levels in vitro, suggesting its potential as an adjunct therapy for oxidative stress-related ailments.
Beyond its antioxidant effects, isosilybin has also been investigated for its anti-inflammatory properties. Inflammation is a hallmark of many chronic diseases, such as arthritis, diabetes, and cancer. Studies have shown that isosilybin inhibits the production of pro-inflammatory cytokines like TNF-α and IL-6, which are central mediators of inflammatory responses. These findings underscore its potential as a natural anti-inflammatory agent.
The hepatoprotective effects of isosilybin are another area of intense research interest. Milk thistle has long been used traditionally to support liver health, and modern studies have validated these claims. Recent research indicates that isosilybin can protect liver cells from damage caused by toxins and oxidative stress. It achieves this by upregulating detoxification enzymes and reducing lipid peroxidation in hepatocytes.
In addition to its direct biological effects, isosilybin has shown promise in modulating cellular signaling pathways associated with cancer progression. For instance, studies have demonstrated that isosilybin induces apoptosis in cancer cells while sparing healthy cells—an attribute that makes it a potential candidate for targeted cancer therapies. Furthermore, its ability to inhibit tumor angiogenesis adds to its anticancer potential.
The bioavailability of isosilybin, however, remains a critical consideration for its therapeutic application. Research suggests that while it exhibits strong activity in vitro, its absorption and metabolism in vivo may limit its efficacy. To address this challenge, scientists are exploring novel delivery systems, such as nanotechnology-based formulations, to enhance the bioavailability of isosilybin.
In conclusion, CAS No 72581-71-6, or isosilybin strong>, represents a valuable natural compound with multifaceted bioactive properties. Its antioxidant, anti-inflammatory, hepatoprotective, and anticancer activities make it a compelling subject for further research and development. As ongoing studies continue to unravel its mechanisms of action and optimize its delivery, < strong >isosily bin strong > holds great promise as a novel therapeutic agent in modern medicine. p> article > response >
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