Cas no 2227068-88-2 (O-[(1,1-Dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-L-threonine 5-[[(phenylmethoxy)carbonyl]amino]pentyl ester)

O-[(1,1-Dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-L-threonine 5-[[(phenylmethoxy)carbonyl]amino]pentyl ester structure
2227068-88-2 structure
Product Name:O-[(1,1-Dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-L-threonine 5-[[(phenylmethoxy)carbonyl]amino]pentyl ester
CAS No:2227068-88-2
MF:C41H50N2O7Si
MW:710.930412769318
CID:6624937
Update Time:2024-01-19

O-[(1,1-Dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-L-threonine 5-[[(phenylmethoxy)carbonyl]amino]pentyl ester Chemical and Physical Properties

Names and Identifiers

    • O-[(1,1-Dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-L-threonine 5-[[(phenylmethoxy)carbonyl]amino]pentyl ester
    • Inchi： 1S/C41H50N2O7Si/c1-32(50-51(41(2,3)4,35-24-14-7-15-25-35)36-26-16-8-17-27-36)37(43-40(46)49-31-34-22-12-6-13-23-34)38(44)47-29-19-9-18-28-42-39(45)48-30-33-20-10-5-11-21-33/h5-8,10-17,20-27,32,37H,9,18-19,28-31H2,1-4H3,(H,42,45)(H,43,46)/t32-,37+/m1/s1
    • InChI Key： WFANMHHPDGZMIX-JJQXXVEZSA-N
    • SMILES： C(OCCCCCNC(OCC1=CC=CC=C1)=O)(=O)[C@H]([C@H](O[Si](C(C)(C)C)(C1=CC=CC=C1)C1=CC=CC=C1)C)NC(OCC1=CC=CC=C1)=O

Experimental Properties

  • Density: 1.16±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
  • Boiling Point: 769.4±60.0 °C(Predicted)
  • pka: 10.42±0.46(Predicted)

O-[(1,1-Dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-L-threonine 5-[[(phenylmethoxy)carbonyl]amino]pentyl ester Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Imidazole Catalysts: 4-(Dimethylamino)pyridine Solvents: Dimethylformamide ;  7 h, 45 °C
2.1 Reagents: Sodium hydroxide Solvents: Dimethylformamide ,  Water ;  2 h, rt
2.2 Reagents: Hydrochloric acid Solvents: Water ;  rt
3.1 Reagents: Diisopropylcarbodiimide ,  1-Hydroxybenzotriazole Catalysts: 4-(Dimethylamino)pyridine Solvents: Dimethylformamide ,  Dichloromethane ;  20 min, 90 °C
3.2 Solvents: Dichloromethane ;  1 h
Reference
Simple and Practical Real-Time Analysis of Solid-Phase Reactions by Thin-Layer Chromatography
Wu, Chia-Hui; et al, Synlett, 2018, 29(11), 1430-1436

Production Method 2

Reaction Conditions
1.1 Reagents: Diisopropylcarbodiimide ,  1-Hydroxybenzotriazole Catalysts: 4-(Dimethylamino)pyridine Solvents: Dimethylformamide ,  Dichloromethane ;  20 min, 90 °C
1.2 Solvents: Dichloromethane ;  1 h
Reference
Simple and Practical Real-Time Analysis of Solid-Phase Reactions by Thin-Layer Chromatography
Wu, Chia-Hui; et al, Synlett, 2018, 29(11), 1430-1436

Production Method 3

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Dimethylformamide ,  Water ;  2 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  rt
2.1 Reagents: Diisopropylcarbodiimide ,  1-Hydroxybenzotriazole Catalysts: 4-(Dimethylamino)pyridine Solvents: Dimethylformamide ,  Dichloromethane ;  20 min, 90 °C
2.2 Solvents: Dichloromethane ;  1 h
Reference
Simple and Practical Real-Time Analysis of Solid-Phase Reactions by Thin-Layer Chromatography
Wu, Chia-Hui; et al, Synlett, 2018, 29(11), 1430-1436

O-[(1,1-Dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-L-threonine 5-[[(phenylmethoxy)carbonyl]amino]pentyl ester Raw materials

O-[(1,1-Dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-L-threonine 5-[[(phenylmethoxy)carbonyl]amino]pentyl ester Preparation Products

O-[(1,1-Dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-L-threonine 5-[[(phenylmethoxy)carbonyl]amino]pentyl ester Related Literature

2227068-88-2 (O-[(1,1-Dimethylethyl)diphenylsilyl]-N-[(phenylmethoxy)carbonyl]-L-threonine 5-[[(phenylmethoxy)carbonyl]amino]pentyl ester) Related Products

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