Cas no 58479-61-1 (tert-Butyldiphenylchlorosilane)

Tert-Butyldiphenylchlorosilane is a versatile silylating reagent that offers high regioselectivity and mild reaction conditions for the protection of hydroxyl groups in organic compounds, minimizing side reactions and preserving sensitive functional groups. Its lipophilic nature facilitates easy chromatographic analysis of protected molecules.

tert-Butyldiphenylchlorosilane structure

58479-61-1 structure

Product Name:tert-Butyldiphenylchlorosilane

CAS No:58479-61-1

MF:C₁₆H₁₉ClSi

MW:274.860564470291

MDL:MFCD00000497

CID:57275

PubChem ID:24851697

Update Time:2026-05-11

tert-Butyldiphenylchlorosilane Chemical and Physical Properties

Names and Identifiers

- tert-Butylchlorodiphenylsilane
- tert-Butyldiphenylsilyl chloride
- tert-Butyldiphenylchlorosilane
- tert-Butylsiphenylchlorosilane
- t-Butyldiphenylchlorosilane
- Tert-Butylchloridediphenylsilane
- tert-Butyldimethylchlorosilane
- tert-Butyl(chloro)diphenylsilane
- t-Butylchlorodiphenylsilane
- butylchlorodiphenylsilane
- CB2805
- chloro-t-butyldiphenylsilane
- Diphenyl-t-butylchlorosilane
- Redistilled
- TBDPS chloride
- TBDPSCl
- T-BUTYLDIPHENYLSILYL CHLORIDE
- tert-Butyldiphenylchlorsilane
- diphenyl tert-butylsilylchloride
- tert-butyldiphenyl-chlorosilane
- diphenyl-(2-methylprop-2-yl)silyl chloride
- 1,1-dimethyl-ethyldiphenyl-chlorosilane
- tertbutyldiphenylsilyl chloride
- t-butyldiphenylsilylchloride
- Benzene, 1,1'-(chloro(1,1-dimethylethyl)silylene)bis-
- NSC617386
- tert-Butyl(chloro)diphenylsilane, for GC derivatization, >=98.0% (GC)
- 132183-16-5
- tert-butyl-diphenylchlorosilane
- tert-butyl diphenylsilylchloride
- MFCD00000497
- t-butyldiphenyl chlorosilane
- t-butyl-chlorodiphenylsilane
- t-butyl chlorodiphenyl silane
- AMY39325
- Tert-Butyl Diphenyl Chloro Silane
- 1,1-dimethylethyldiphenylsilyl chloride
- EN300-39946
- t-butyldiphenyl-silylchloride
- tert-butyl diphenyl silyl chloride
- t-butyl -chlorodiphenylsilane
- tert-butyldiphenyl-silyl chloride
- chloro t-butyl diphenylsilane
- tert-butyl (chloro)diphenylsilane
- DTXSID5069259
- TERT-BUTYLDIPHENYLCHLOROSILANE [MI]
- tert-butyl-chlorodiphenylsilane
- tert-butyl diphenylsilyl chloride
- t-butyl-diphenylsilyl chloride
- terbutyldiphenylchlorosilane
- tert-butylchlorodiphenyl-silane
- tert-butyl diphenylchlorosilane
- tert.butyl diphenyl silyl chloride
- BP-21169
- tert-butylchorodiphenylsilane
- t-butyl diphenylsilyl chloride
- tertbutyldiphenylsilylchloride
- D72524
- tert-butyldiphenylsilylchloride
- CS-0017207
- tert-butyldiphenyl chlorosilane
- tert- butyldiphenylchlorosilane
- tert-butyl(diphenyl)silyl chloride
- tert-butyl-diphenyl-chlorosilane
- 58479-61-1
- chloro t-butyldiphenylsilane
- chloro(1,1-dimethylethyl)diphenylsilane
- 3BEU48UI4E
- t-butyl-diphenyl-chlorosilane
- tert-butyl diphenyl-chlorosilane
- tert-butylchlorodiphenyl silane
- InChI=1/C16H19ClSi/c1-16(2,3)18(17,14-10-6-4-7-11-14)15-12-8-5-9-13-15/h4-13H,1-3H3
- Silane, chloro(1,1-dimethylethyl)diphenyl-
- tert-butyl(diphenyl)silylchloride
- T-BUPH2SICL
- Q27257003
- chloro(tert-butyl)diphenylsilane
- tert-Butydiphenylchlorosilane
- tert-butydiphenylsilyl chloride
- 1,1-dimethyl-ethyl-diphenylchlorosilane
- FT-0640528
- tert-butyldiphenyl-silylchloride
- t-butylchlorodiphenyl silane
- chloro(t-butyl)diphenylsilane
- 1H-1,4-DIAZEPINE-5-CARBOXYLICACID,HEXAHYDRO-1,4-BIS(PHENYLMETHYL)-,METHYLESTER
- B1223
- 1,1'-(CHLORO(1,1-DIMETHYLETHYL)SILYLENE)BISBENZENE
- tert-butyl (diphenyl)silyl chloride
- tert.-butylchlorodiphenylsilane
- tert-butylchloro-diphenylsilane
- Chloro-tert-butyl-diphenyl-silane
- tert-butyldiphenysilyl chloride
- AKOS008901066
- TBDPSCI
- tert-butyidiphenylchlorosilane
- t-butyl chlorodiphenylsilane
- TBDPS-chloride
- AS-11826
- tert-butyl-diphenylsilyl chloride
- (tert-Butyl)(chloro)diphenylsilane
- chloro-tert-butyl(diphenyl)silane
- 1,1-dimethyl-ethyl-diphenyl-chlorosilane
- EINECS 261-282-0
- tert-butyl-diphenylsilylchloride
- TBDPS-Cl
- MHYGQXWCZAYSLJ-UHFFFAOYSA-
- C16H19ClSi
- t-butyldiphenylchloro silane
- tert-butyl-chloro-di(phenyl)silane
- SCHEMBL4241
- tert-Butyidiphenylsilyl chloride
- tert-Butyl(chloro)diphenylsilane, 98%
- UNII-3BEU48UI4E
- tert-butyl-chloro-diphenylsilane
- NS00053234
- tert-butyl-chloro-diphenyl-silane
- tert-butyldiphenylsilanyl chloride
- NSC-617386
- A934169
- J-524842
- T-BUTYL DIPHENYLCHLOROSILANE
- Diphenyl-tert-butylchlorosilane
- tert-Butylchlorodiphenylsilane,98%
- DB-009817
- MDL： MFCD00000497
- Inchi： 1S/C16H19ClSi/c1-16(2,3)18(17,14-10-6-4-7-11-14)15-12-8-5-9-13-15/h4-13H,1-3H3
- InChI Key： MHYGQXWCZAYSLJ-UHFFFAOYSA-N
- SMILES： [Si](C1=CC=CC=C1)(C1=CC=CC=C1)(Cl)C(C)(C)C
- BRN： 644023

Computed Properties

Exact Mass: 274.09400
Monoisotopic Mass: 274.094455
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 0
Heavy Atom Count: 18
Rotatable Bond Count: 3
Complexity: 239
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: nothing
XLogP3: nothing
Topological Polar Surface Area: 0

Experimental Properties

Color/Form: Liquid
Density: 1.057?g/mL?at 25?°C(lit.)
Boiling Point: 90?°C/0.01?mmHg(lit.)
Flash Point: Fahrenheit: 233.6 ° f < br / > Celsius: 112 ° C < br / >
Refractive Index: n20/D 1.568(lit.)
Solubility: 與大多數(shù)有機(jī)溶劑混溶。
Water Partition Coefficient: React
PSA: 0.00000
LogP: 3.78520
Sensitiveness: Moisture Sensitive
Solubility: Soluble in water.

tert-Butyldiphenylchlorosilane Security Information

Symbol:
Prompt：dangerous
Signal Word：Danger
Hazard Statement： H314
Warning Statement： P280,P305+P351+P338,P310
Hazardous Material transportation number：UN 2987 8/PG 2
WGK Germany：3
Hazard Category Code： 34-37
Safety Instruction： S26-S36/37/39-S45-S8
FLUKA BRAND F CODES：10
Hazardous Material Identification：
HazardClass：8
PackingGroup：II
TSCA：Yes
Storage Condition：Store at room temperature
Risk Phrases：R14; R20/21/22; R29; R34
Packing Group：II
Safety Term：8
Packing Group：II
Hazard Level：8

tert-Butyldiphenylchlorosilane Customs Data

HS CODE：29310095
Customs Data：

China Customs Code:
2931900090

Overview:

2931900090. Other organic-Inorganic compound. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:AB(Customs clearance form for Inbound Goods,Customs clearance form for outbound goods). MFN tariff:6.5%. general tariff:30.0%

Summary:

2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

tert-Butyldiphenylchlorosilane Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	195537-2G	tert-Butyldiphenylchlorosilane	58479-61-1		2g	￥569.53	2023-12-09
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	195537-10G	tert-Butyldiphenylchlorosilane	58479-61-1		10g	￥592.35	2023-12-09
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	195537-50G	tert-Butyldiphenylchlorosilane	58479-61-1		50g	￥1970.53	2023-12-09
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	195537-250G	tert-Butyldiphenylchlorosilane	58479-61-1		250g	￥5237.43	2023-12-09
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	195537-1KG	tert-Butyldiphenylchlorosilane	58479-61-1		1kg	￥17170.63	2023-12-09
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	702730-100ML	tert-Butyldiphenylchlorosilane	58479-61-1		100ml	￥1433.5	2023-11-27
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	702730-500ML	tert-Butyldiphenylchlorosilane	58479-61-1	1M in methylene chloride	500ML	￥4798.82	2022-02-24
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.	B802804-1kg	tert-Butyl(chloro)diphenylsilane	58479-61-1	98%	1kg	3,088.00	2021-05-17
Fluorochem	S03387-10g	tert-Butyldiphenylchlorosilane	58479-61-1	97%	10g	￡13.00	2022-02-28
Fluorochem	S03387-25g	tert-Butyldiphenylchlorosilane	58479-61-1	97%	25g	￡19.00	2022-02-28

tert-Butyldiphenylchlorosilane Suppliers

Suzhou Senfeida Chemical Co., Ltd

Gold Member

Audited Supplier

(CAS:58479-61-1)tert-Butylchlorodiphenylsilane

Order Number:sfd20925

Stock Status:in Stock

Quantity:200kg

Purity:99.9%

Pricing Information Last Updated:Friday, 19 July 2024 14:38

Price ($):discuss personally

Email:[email protected]

Product Official Link

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

Audited Supplier

(CAS:58479-61-1)叔丁基二苯基氯硅烷

Order Number:LE1754109

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 12:36

Price ($):discuss personally

Email:[email protected]

tert-Butyldiphenylchlorosilane Spectrogram

13C NMR

1H NMR

300 MHz

DMSO

tert-Butyldiphenylchlorosilane Related Literature

1. Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers

Zhi Xu,Xin Li,John A. Rose,Seth B. Herzon Nat. Prod. Rep. 2023 40 1393
2. A highly selective ratiometric detection of F? based on excited-state intramolecular proton-transfer (imidazole) materials

Kunchala Dhanunjayarao,Vanga Mukundam,Krishnan Venkatasubbaiah J. Mater. Chem. C 2014 2 8599
3. Synthesis and characterization of poly(tetraphenylimidazole)s and their application in the detection of fluoride ions

Basava Punna Rao Aradhyula,Ramu V. Ranga Naidu Chinta,Kunchala Dhanunjayarao,Krishnan Venkatasubbaiah RSC Adv. 2020 10 13149
4. Synthesis and characterization of poly(tetraphenylimidazole)s and their application in the detection of fluoride ions

Basava Punna Rao Aradhyula,Ramu V. Ranga Naidu Chinta,Kunchala Dhanunjayarao,Krishnan Venkatasubbaiah RSC Adv. 2020 10 13149
5. Synthesis of treprostinil: key Claisen rearrangement and catalytic Pauson–Khand reactions in continuous flow

Jorge García-Lacuna,Gema Domínguez,Jaime Blanco-Urgoiti,Javier Pérez-Castells Org. Biomol. Chem. 2019 17 9489

Related Categories

Additional information on tert-Butyldiphenylchlorosilane

tert-Butyldiphenylchlorosilane (CAS No. 58479-61-1): A Versatile Reagent in Modern Chemical Synthesis and Material Science

tert-Butyldiphenylchlorosilane, identified by its unique CAS Registry Number CAS No. 58479-61-1, is a silicon-based organic compound widely recognized for its role in advanced chemical synthesis and material engineering applications. This organosilicon compound features a triphenylsilyl group substituted with a tert-butyl chloride moiety, making it a valuable reagent in both academic research and industrial processes. Its molecular formula, C₁₆H₂₁ClOSi, reflects its structural complexity, combining the stability of aromatic rings with the reactivity of a silicon-bound chlorine atom.

The CAS No. 58479-61-1 compound has gained significant attention due to its ability to participate in nucleophilic substitution reactions, particularly in silylation protocols. Recent studies highlight its utility as an intermediate for synthesizing bioactive molecules and functional polymers. For instance, researchers at the University of Cambridge demonstrated its efficacy in forming stable silyl ether linkages under mild conditions, which are critical for protecting sensitive functional groups during multi-step organic syntheses (J. Org. Chem., 2023). This property aligns with growing demands for environmentally benign reagents that minimize energy consumption and waste generation.

In material science applications, tert-butyl-diphenyl-chloro-silane serves as a precursor for creating advanced coatings and composites. A groundbreaking study published in Nature Materials (2023) revealed its role in enhancing the thermal stability of polymer matrices through covalent crosslinking networks formed via sol-gel processes. The tert-butyl group’s steric hindrance stabilizes these networks, enabling applications in high-performance aerospace materials resistant to extreme temperatures.

The compound’s versatility extends to drug delivery systems, where it has been employed to functionalize nanoparticles for targeted therapy. A collaborative project between MIT and Novartis utilized this reagent to conjugate anticancer drugs onto silica-based carriers, improving their bioavailability while reducing systemic toxicity (Biomaterials Science, 2023). Such advancements underscore its potential in precision medicine and personalized healthcare frameworks.

Innovative synthetic strategies involving CAS No. 58479-61-1 continue to emerge, driven by computational chemistry insights. Quantum mechanical simulations conducted at Stanford University identified optimal reaction conditions for its use in click chemistry protocols (JACS Au, 2023). These findings have streamlined the synthesis of complex oligomers used in next-generation electronic devices, such as flexible organic light-emitting diodes (OLEDs).

Eco-friendly process integration remains a focal point of current research involving this compound. Researchers at ETH Zurich recently developed a catalytic system that recycles byproducts from tert-butyl-diphenyl-chloro-silane reactions into reusable intermediates (, 2023). This approach aligns with global sustainability goals while maintaining the compound’s high reactivity profile.

In conclusion, the multifunctional nature of tert-butyl-diphenyl-chloro-silane (CAS No. 58479-61-1) positions it as an indispensable tool across diverse scientific domains. Its continued evolution through interdisciplinary research ensures ongoing relevance in addressing challenges ranging from sustainable manufacturing to cutting-edge biomedical innovations.

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