Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers
Natural Product Reports Pub Date: 2023-04-17 DOI: 10.1039/D3NP00008G
Abstract
Covering: up to 2022
Tricyclic bridgehead carbon centers (TBCCs) are a synthetically challenging substructure found in many complex natural products. Here we review the syntheses of ten representative families of TBCC-containing isolates, with the goal of outlining the strategies and tactics used to install these centers, including a discussion of the evolution of the successful synthetic design. We provide a summary of common strategies to inform future synthetic endeavors.
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Journal Name：Natural Product Reports
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CAS no.: 89640-58-4
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