Production Method 1

136059-92-2

446-48-0

19883-78-4

2629-55-2

97731-02-7

Reaction Conditions

1.1 Catalysts: 2-Methyl-N-(tri-1-pyrrolidinylphosphoranylidene)-2-propanamine Solvents: N-Methyl-2-pyrrolidone ;  2 d, 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  20 min, 25 °C
1.3 Reagents: Diisopropylethylamine
1.4 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ,  Water ;  30 min, 25 °C

Reference

Antibacterials and/or modulators of biofilm formation and methods of using the same

, United States, , ,

Production Method 2

2629-55-2

19883-78-4

97731-02-7

151911-22-7

Reaction Conditions

1.1 Catalysts: Racemase, alanine ,  Aminomutase, phenylalanine 2,3- Solvents: Water ;  20 h, pH 8.0, 31 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 10 - 12

Reference

Enhanced Conversion of Racemic α-Arylalanines to (R)-β-Arylalanines by Coupled Racemase/Aminomutase Catalysis

Cox, Brad M.; et al, Journal of Organic Chemistry, 2009, 74(18), 6953-6959

Production Method 3

2629-55-2

19883-78-4

97731-02-7

Reaction Conditions

1.1 Reagents: N-[3-[[[(1S)-3′-Formyl-2′-hydroxy[1,1′-binaphthalen]-2-yl]oxy]methyl]phenyl]-N′-… Solvents: Dimethyl sulfoxide
1.1 Reagents: N-[3-[[(3′-Formyl-2′-hydroxy[1,1′-binaphthalen]-2-yl)oxy]methyl]phenyl]-N′-pheny… Solvents: Dimethyl sulfoxide

Reference

Deracemization of racemic amino acids using (R)- and (S)-alanine racemase chiral analogues as chiral convertersDeracemization of racemic amino acids using (R)- and (S)-alanine racemase chiral analogues as chiral converters

Paik, Man-Jeong; et al Paik, Man-Jeong; et al, Bulletin of the Korean Chemical Society, 2014, 35(7), 2186-2188

2-Fluoro-L-phenylalanine Raw materials

• 2-Amino-3-(2-fluorophenyl)propanoic acid
• Glycine, N-(diphenylmethylene)-
• 1-(bromomethyl)-2-fluorobenzene

2-Fluoro-L-phenylalanine Preparation Products

• 2-Amino-3-(2-fluorophenyl)propanoic acid (2629-55-2)
• (R)-2-Amino-3-(2-fluorophenyl)propanoic acid (97731-02-7)
• (R)-3-Amino-3-(2-fluoro-phenyl)-propionic acid (151911-22-7)
• 2-Fluoro-L-phenylalanine (19883-78-4)

• 1. A periodic development of BPA and BSH based derivatives in boron neutron capture therapy (BNCT)
  Manisha Lamba,Avijit Goswami,Anupam Bandyopadhyay Chem. Commun. 2021 57 827
• 2. Looking into a crystal ball: printing and patterning self-assembled peptide nanostructures
  Wendel A. Alves,Gavin M. King,Suchismita Guha Nanoscale 2022 14 15607
• 3. Novel soraphens from precursor directed biosynthesis
  Alison M. Hill,Betty L. Thompson Chem. Commun. 2003 1360
• 4. α-Chymotrypsin-catalysed peptide synthesis using activated esters as acyl donors
  Toshifumi Miyazawa,Shin'ichi Nakajo,Miyako Nishikawa,Kiwamu Imagawa,Ryoji Yanagihara,Takashi Yamada J. Chem. Soc. Perkin Trans. 1 1996 2867

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 2629-55-2(2-Amino-3-(2-fluorophenyl)propanoic acid)
• 266360-60-5(2,4-Difluoro-D-Phenylalanine)
• 51-65-0(2-Amino-3-(4-fluorophenyl)propanoic acid)
• 97731-02-7((R)-2-Amino-3-(2-fluorophenyl)propanoic acid)
• 1132-68-9(p-Fluoro-L-phenylalanine)
• 110117-84-5(H-D-Phe(3-F)-OH)
• 18125-46-7((2R)-2-amino-3-(4-fluorophenyl)propanoic acid)
• 19883-77-3(3-Fluoro-L-phenylalanine)
• 40332-58-9((R)-2-Amino-3-(perfluorophenyl)propanoic acid)
• 33787-05-2(L-2,6-Difluorophenylalanine)