Production Method 1

18362-36-2

824-42-0

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: N,N,N′,N′-Tetramethylethylenediamine
1.2 -
1.3 Reagents: Hydrochloric acid

Reference

Directing effect of 1,3-dimethylimidazolidine in ortho lithiation changes with its vicinal group

Tamura, Eiko; et al, Synlett, 1994, (8), 609-10

Production Method 2

940003-50-9

18362-36-2

824-42-0

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Dimethylformamide
1.2 Reagents: Water

Reference

Insertion of arynes into the carbon-oxygen double bond of amides and its application into the sequential reactions

Yoshioka, Eito; et al, Tetrahedron, 2012, 68(1), 179-189

2-Hydroxy-6-methylbenzaldehyde Raw materials

• 3-Methyl-2-(trimethylsilyl)phenyl 1,1,1-trifluoromethanesulfonate

2-Hydroxy-6-methylbenzaldehyde Preparation Products

• 2-Hydroxy-3-methylbenzaldehyde (824-42-0)
• 2-Hydroxy-6-methylbenzaldehyde (18362-36-2)

• 1. An investigation on the second-order nonlinear optical response of cationic bipyridine or phenanthroline iridium(iii) complexes bearing cyclometallated 2-phenylpyridines with a triphenylamine substituent?
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Aldehydes

2-Hydroxy-6-methylbenzaldehyde: Properties, Applications, and Market Insights

2-Hydroxy-6-methylbenzaldehyde (CAS No. 18362-36-2) is a versatile organic compound with a molecular formula of C8H8O2. This aromatic aldehyde features both hydroxyl and aldehyde functional groups, making it a valuable intermediate in various chemical syntheses. The compound is also known by other names such as 6-methylsalicylaldehyde and 2-hydroxy-6-methylbenzaldehyde, which are frequently used in scientific literature.

The physical properties of 2-Hydroxy-6-methylbenzaldehyde include a pale yellow to white crystalline appearance, with a melting point ranging between 45-50°C. Its solubility profile shows good dissolution in organic solvents like ethanol, methanol, and acetone, while being sparingly soluble in water. The chemical structure of this compound, featuring a hydroxyl group at the 2-position and a methyl group at the 6-position of the benzene ring, contributes to its unique reactivity and applications.

In recent years, 2-Hydroxy-6-methylbenzaldehyde has gained attention in the field of organic synthesis and pharmaceutical intermediates. Researchers are particularly interested in its potential as a building block for flavonoid derivatives and antioxidant compounds, which aligns with current trends in natural product chemistry and health-related applications. The compound's ability to form Schiff bases makes it valuable in coordination chemistry and material science applications.

The industrial applications of 2-Hydroxy-6-methylbenzaldehyde span several sectors. In the fragrance industry, it serves as a precursor for certain aroma chemicals. The pharmaceutical industry utilizes this compound in the synthesis of various drug intermediates, particularly those with antimicrobial or anti-inflammatory properties. Additionally, its derivatives find use in agrochemicals and dye manufacturing, making it a compound of significant commercial interest.

From a market perspective, the demand for 2-Hydroxy-6-methylbenzaldehyde has shown steady growth, particularly in regions with strong pharmaceutical and specialty chemical industries. Manufacturers are focusing on developing more efficient synthesis routes to meet the increasing demand while maintaining high purity standards. The global market for such fine chemicals is expected to grow in response to the expanding pharmaceutical and agrochemical sectors.

Recent research developments have explored novel applications of 2-Hydroxy-6-methylbenzaldehyde in material science, particularly in the design of functional polymers and coordination complexes. Its ability to act as a ligand in metal-organic frameworks (MOFs) has opened new possibilities in catalysis and gas storage applications. These advancements align with current interests in sustainable materials and green chemistry initiatives.

Quality control and analytical methods for 2-Hydroxy-6-methylbenzaldehyde typically involve techniques such as HPLC, GC-MS, and NMR spectroscopy. These methods ensure the compound meets the required purity standards for various applications. Storage recommendations generally include keeping the material in a cool, dry place away from strong oxidizing agents to maintain stability.

For researchers and industry professionals seeking information about 2-Hydroxy-6-methylbenzaldehyde synthesis or 2-Hydroxy-6-methylbenzaldehyde suppliers, it's important to note that several specialty chemical manufacturers offer this compound in various quantities and purity grades. The compound's safety data indicates standard handling precautions for laboratory chemicals, with proper ventilation and personal protective equipment recommended during use.

The future outlook for 2-Hydroxy-6-methylbenzaldehyde appears promising, with potential applications emerging in biomedical research and advanced materials. As synthetic methodologies continue to advance, this compound may find even broader utility in various scientific and industrial fields. Its unique structural features make it a valuable tool for chemists exploring new molecular architectures and functional materials.

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