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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds N-acetylarylamines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds N-arylamides N-acetylarylamines

Comprehensive Analysis of N-(2-Methylpyridin-4-yl)acetamide (CAS No. 18085-47-7): Properties, Applications, and Industry Insights

N-(2-Methylpyridin-4-yl)acetamide (CAS No. 18085-47-7), a specialized organic compound, has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural features. This acetamide derivative combines a pyridine ring with an N-acetyl functional group, making it a versatile intermediate in synthetic chemistry. Recent studies highlight its potential as a building block for drug discovery, particularly in developing kinase inhibitors and antimicrobial agents.

The molecular structure of N-(2-Methylpyridin-4-yl)acetamide features a 2-methylpyridine moiety at the 4-position, which enhances its solubility in polar solvents compared to simpler pyridine derivatives. With a molecular weight of 150.18 g/mol and melting point range of 98-102°C, this compound exhibits stability under standard laboratory conditions. Researchers frequently inquire about its synthetic routes – the most common method involves the acetylation of 4-amino-2-methylpyridine using acetic anhydride under controlled conditions.

In pharmaceutical applications, CAS 18085-47-7 serves as a precursor for heterocyclic compounds with potential biological activity. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its utility in creating selective enzyme modulators. The compound's electron-rich pyridine nitrogen allows for diverse chemical modifications, addressing the growing demand for structure-activity relationship studies in drug development pipelines.

The agrochemical sector has explored N-(2-Methylpyridin-4-yl)acetamide as a potential plant growth regulator intermediate. Its structural similarity to nicotinamide derivatives makes it particularly interesting for developing sustainable crop protection solutions. Industry reports indicate increasing patent filings involving this compound for biodegradable pesticide formulations, aligning with the global shift toward eco-friendly agriculture practices.

Analytical characterization of 18085-47-7 typically employs HPLC purification (reverse-phase C18 columns) and structural confirmation via NMR spectroscopy (characteristic peaks at δ 2.3 ppm for methyl protons and δ 8.3 ppm for pyridine protons). Quality control protocols emphasize chromatographic purity (>98%) due to its pharmaceutical applications. Recent advancements in continuous flow chemistry have improved the scalability of its production while reducing organic solvent waste.

From a commercial perspective, N-(2-Methylpyridin-4-yl)acetamide has seen steady demand growth (CAGR 4.7% from 2020-2023 according to industry analysts). Suppliers typically offer it in kilogram-scale quantities with customized packaging options. The compound's global market distribution shows concentration in pharmaceutical manufacturing hubs, with increasing interest from contract research organizations specializing in fragment-based drug discovery.

Environmental and safety profiles of CAS 18085-47-7 have been thoroughly documented. While not classified as hazardous under GHS criteria, standard laboratory precautions (gloves, eye protection) are recommended during handling. Its biodegradation pathway has been studied in OECD 301 tests, showing complete mineralization within 28 days under aerobic conditions – a crucial factor for green chemistry applications.

Emerging research directions include exploring metal-organic frameworks incorporating this acetamide derivative for catalytic applications, and its potential in photodynamic therapy precursors. The compound's structure-property relationships continue to be investigated through computational chemistry methods, particularly density functional theory (DFT) calculations predicting its reactivity patterns.

For researchers sourcing N-(2-Methylpyridin-4-yl)acetamide, key considerations include supplier certifications (ISO 9001 compliance), batch-to-batch consistency, and availability of analytical data sheets. The compound's stability under various storage conditions (recommended: 2-8°C in airtight containers) ensures reliable performance in multi-step syntheses. Current price trends reflect its position as a specialty chemical, with bulk purchasing options becoming more accessible.

Future outlook for 18085-47-7 remains positive as drug discovery programs increasingly target nitrogen-containing heterocycles. Its balanced lipophilicity profile (calculated logP ≈ 0.9) makes it particularly valuable for central nervous system drug candidates. Ongoing optimization of synthetic methodologies may further enhance its commercial viability in coming years.

• 1180133-88-3(N-[2-[(4-methyl-1-piperazinyl)methyl]-4-pyridinyl]-Acetamide)
• 126220-99-3(Formamide, N-(2,6-dimethyl-4-pyridinyl)- (9CI))
• 5221-42-1(N-(pyridin-4-yl)acetamide)
• 6269-73-4(N-(4-acetamido-2-methylquinolin-6-yl)acetamide)
• 90873-00-0(N-(5-Ethyl-2-methylpyridin-4-yl)acetamide)
• 179022-67-4(N-(2,6-Dimethylpyridin-4-yl)acetamide)
• 52101-48-1(Acetamide, N-(2-methyl-4-quinolinyl)-)
• 29958-15-4(N-(6-Methylpyridin-3-yl)acetamide)
• 34050-39-0(N-(2-methyl-3-pyridinyl)-Acetamide)
• 1206484-22-1(N-(4-amino-2-methyl-3-pyridinyl)-Acetamide)