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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

6-(2-Thienyl)nicotinic Acid (CAS No. 179408-54-9): A Versatile Building Block in Medicinal Chemistry and Material Science

6-(2-Thienyl)nicotinic Acid (CAS No. 179408-54-9) is a heterocyclic carboxylic acid compound that has gained significant attention in pharmaceutical research and material science applications. This unique molecule combines the electronic properties of thiophene and nicotinic acid moieties, making it particularly valuable for drug discovery and advanced material development.

The growing interest in 6-(2-Thienyl)nicotinic Acid derivatives reflects current trends in medicinal chemistry, where researchers are actively exploring novel heterocyclic compounds for targeted therapies. Recent studies suggest this compound may serve as a key intermediate in the synthesis of potential kinase inhibitors, addressing one of the most searched topics in pharmaceutical research: "new approaches to cancer treatment."

From a structural perspective, 6-(2-Thienyl)nicotinic Acid features a molecular weight of 205.22 g/mol and typically appears as a white to off-white crystalline powder. Its solubility profile makes it particularly useful in organic synthesis, with moderate solubility in polar organic solvents like DMSO and methanol, while being less soluble in water. These properties are frequently queried in chemical databases, indicating strong researcher interest in its practical handling characteristics.

In pharmaceutical applications, the thienyl-nicotinic acid scaffold has shown promise in multiple therapeutic areas. Recent patent literature reveals its incorporation into molecules being investigated for metabolic disorders and inflammatory conditions, aligning with current healthcare priorities. The compound's ability to participate in various coupling reactions makes it valuable for creating diverse molecular architectures, a feature highly sought after in drug discovery programs.

Material scientists have also taken notice of 6-(2-Thienyl)nicotinic Acid due to its potential in organic electronics. The conjugated system formed by the thiophene and pyridine rings offers interesting electronic properties that could be exploited in organic semiconductors or photovoltaic materials. This application taps into the booming interest in sustainable energy solutions and "green chemistry" approaches.

The synthesis of 6-(2-Thienyl)nicotinic Acid typically involves cross-coupling reactions between appropriately substituted thiophene and pyridine precursors. Recent advancements in catalytic methods have improved the efficiency of these transformations, addressing common search queries about "optimized synthesis routes for heterocyclic compounds." Manufacturers have developed scalable processes to meet the growing demand from both academic and industrial researchers.

Quality control aspects of 6-(2-Thienyl)nicotinic Acid are another area of professional interest. Analytical methods typically include HPLC purity assessment (>98% pure), along with standard spectroscopic characterization (1H NMR, 13C NMR, and mass spectrometry). These specifications frequently appear in procurement inquiries, reflecting the compound's use in sensitive applications where purity is paramount.

From a commercial perspective, the market for 6-(2-Thienyl)nicotinic Acid has shown steady growth, particularly in regions with strong pharmaceutical and advanced materials industries. Current pricing trends and availability are common search terms, indicating the compound's established position in the fine chemicals market. Suppliers typically offer the material in research quantities (100mg to 1g) as well as bulk quantities for industrial applications.

Storage and handling recommendations for 6-(2-Thienyl)nicotinic Acid follow standard protocols for organic compounds. The material should be kept in a cool, dry environment, protected from light and moisture. These practical considerations generate significant search traffic from laboratory professionals seeking proper compound management information.

Recent scientific literature highlights novel applications of 6-(2-Thienyl)nicotinic Acid derivatives in metal-organic frameworks (MOFs) and coordination polymers. These advanced materials have potential applications in gas storage, separation technologies, and catalysis, connecting to trending research topics in materials science and nanotechnology.

The environmental profile of 6-(2-Thienyl)nicotinic Acid has also come under scrutiny as part of the broader movement toward sustainable chemistry. While not classified as hazardous, proper disposal methods and biodegradability studies represent active areas of investigation, responding to increasing regulatory and environmental concerns in chemical research.

Looking forward, the versatility of 6-(2-Thienyl)nicotinic Acid suggests it will maintain its importance in chemical research. Its dual functionality as both a carboxylic acid and heterocyclic compound provides multiple points for structural modification, making it valuable for combinatorial chemistry approaches and high-throughput screening programs.

For researchers considering working with 6-(2-Thienyl)nicotinic Acid, recent publications suggest several promising directions. These include exploring its use in fragment-based drug discovery, developing novel synthetic methodologies, and investigating its photophysical properties for optoelectronic applications. These areas correspond to current "hot topics" in chemical research as identified by literature analysis tools.

In conclusion, 6-(2-Thienyl)nicotinic Acid (CAS No. 179408-54-9) represents a compelling case study in how fundamental chemical building blocks can find diverse applications across multiple scientific disciplines. Its continued relevance in both established and emerging research areas ensures it will remain an important compound in the chemist's toolbox for years to come.

• 851546-83-3(2-Thiophen-2-yl-quinoline-4-carboxylic acid)
• 649557-64-2(3-Pyridinecarboxylicacid, 6-(5-chloro-2-thienyl)-)
• 628703-70-8(2-Thiophenecarboxaldehyde, 5-[5-[(aminooxy)methyl]-2-pyridinyl]-)
• 31792-49-1(6-Methyl-2-(thiophen-2-yl)quinoline-4-carboxylic acid)
• 179408-53-8(3-Pyridinecarboxylicacid, 6-(2-thienyl)-, methyl ester)
• 33289-45-1(8-Methyl-2-(thiophen-2-yl)quinoline-4-carboxylic acid)
• 198078-57-8((6-Thien-2-ylpyrid-3-yl)methanol)
• 893723-57-4(2-(thiophen-2-yl)isonicotinic acid)
• 834884-61-6(6-(thiophen-2-yl)pyridine-3-carbaldehyde)
• 667412-63-7(8-Methyl-2-(5-methylthien-2-yl)quinoline-4-carboxylic Acid)