• 1. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 2. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 3. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 4. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 5. Examination of deposit in commercial diluted phosphoric acid
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives

Comprehensive Analysis of (6-Thien-2-ylpyrid-3-yl)methanol (CAS No. 198078-57-8): Properties, Applications, and Industry Insights

(6-Thien-2-ylpyrid-3-yl)methanol (CAS No. 198078-57-8) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and material science research. This thiophene-pyridine hybrid derivative exhibits unique structural features, combining the electron-rich thienyl moiety with the versatile pyridyl ring, making it a valuable intermediate for drug discovery and functional materials. The presence of the hydroxymethyl group further enhances its reactivity, enabling diverse synthetic transformations.

Recent studies highlight the compound's potential in small-molecule drug development, particularly in targeting protein-protein interactions (PPIs) – a hot topic in cancer therapeutics and neurodegenerative disease research. Its molecular scaffold appears in patent literature as a key fragment for kinase inhibitors, addressing frequently searched queries like "next-generation kinase inhibitors 2024" and "heterocyclic compounds in oncology." The thiophene-pyridine core also demonstrates promising photophysical properties, aligning with growing interest in organic electronic materials for OLED applications.

From a synthetic chemistry perspective, 198078-57-8 serves as a versatile building block for cross-coupling reactions and click chemistry applications. Its methanol functionality allows straightforward derivatization to esters, ethers, or halides – techniques frequently discussed in medicinal chemistry optimization forums. Analytical data shows the compound typically appears as a white to off-white crystalline powder with good solubility in polar organic solvents, a characteristic highly valued in high-throughput screening workflows.

The compound's stability profile meets requirements for FDA-approved intermediate standards, with thermal analysis indicating decomposition above 200°C. This thermal resilience makes it suitable for high-temperature reactions, a feature often queried in process chemistry discussions. Regulatory databases confirm its non-hazardous classification under standard handling conditions, though proper laboratory safety protocols should always be observed when working with any fine chemicals.

Market analysis reveals growing demand for 198078-57-8 from contract research organizations (CROs) and academic research institutions, particularly those investigating fragment-based drug design (FBDD). The compound's Lipinski rule compliance (MW <500, H-bond donors/acceptors ≤5/10) makes it attractive for hit-to-lead optimization – a trending topic in computational chemistry circles. Suppliers typically offer the material at ≥95% purity (HPLC), with custom synthesis options available for isotope-labeled versions used in ADME studies.

Emerging applications in metal-organic frameworks (MOFs) demonstrate the compound's utility beyond life sciences. Its bidentate ligand capability enables construction of novel coordination polymers with potential in gas storage and catalysis – subjects generating substantial academic interest. The thienyl-pyridine system's conjugated π-system also shows promise in organic photovoltaic research, answering industry demands for non-fullerene acceptors in solar cell technology.

Quality control protocols for (6-Thien-2-ylpyrid-3-yl)methanol typically involve HPLC-UV analysis and 1H/13C NMR verification, with residual solvent content meeting ICH guidelines. These rigorous standards address common purchaser concerns about batch-to-batch consistency in fine chemicals. The compound's chromatographic behavior has been well-characterized, facilitating method development for related analogs – a practical consideration for researchers searching "HPLC method development for heterocycles."

Future research directions likely explore the compound's chiral derivatives, given increasing focus on asymmetric synthesis in drug development. Preliminary computational studies suggest interesting molecular docking potential at various biological targets, particularly those involving allosteric modulation mechanisms. These developments position CAS 198078-57-8 as a compound of continuing relevance across multiple scientific disciplines.

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