Cas no 175137-28-7 (Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate)
Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate is a versatile pyrimidine derivative with significant utility in pharmaceutical and agrochemical research. Its structure features a hydrazinyl group and a trifluoromethyl substituent, enhancing reactivity and enabling diverse functionalization. The ester moiety at the 5-position facilitates further derivatization, making it a valuable intermediate for synthesizing heterocyclic compounds. The trifluoromethyl group contributes to improved metabolic stability and lipophilicity, which is advantageous in drug design. This compound is particularly useful in the development of bioactive molecules, including kinase inhibitors and antimicrobial agents. Its well-defined reactivity profile and synthetic flexibility make it a preferred choice for medicinal chemistry applications.
175137-28-7 structure
Product Name:Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate
CAS No:175137-28-7
MF:C7H7F3N4O2
MW:236.151291131973
MDL:MFCD00068147
CID:135418
PubChem ID:2775256
Update Time:2025-10-29
Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate Chemical and Physical Properties
Names and Identifiers
-
- Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate
- 5-(Methoxycarbonyl)-4-(trifluoromethyl)pyrimidine-2-hydrazine
- 5-Pyrimidinecarboxylicacid, 2-hydrazinyl-4-(trifluoromethyl)-, methyl ester
- methyl 2-hydrazino-4-(trifluoromethyl)pyrimidine-5-carboxylate
- AC1MCQ3I
- CTK4D5333
- MolPort-000-156-794
- SBB098543
- SureCN6475927
- BUTTPARK 47\18-19
- 5-(Methoxycarbonyl)-4-(Trifluoromethyl)Pyrimidin
- 5-(Methoxycarbonyl)-4-(trifluoromethyl)pyrimidine-
- 5-(Methoxycarbony)-4-(trifluoromethyl)pyrimidine-2-hyrdrazine
- METHYL 4-(TRIFLUOROMETHYL)-2-HYDRAZINYLPYRIMIDINE-5-CARBOXYLATE
- 5-(METHOXYCARBONYL)-4-(TRIFLUOROMETHYL)PYRIMIDINE- 95+%
- 5-(Methoxycarbonyl)-4-(trifluoromethyl)pyrimidine-2-hydrazine 95%
- 175137-28-7
- MFCD00068147
- LIMNVGGTQCLNNP-UHFFFAOYSA-N
- DTXSID30379478
- 5-Pyrimidinecarboxylicacid,2-hydrazinyl-4-(trifluoromethyl)-,methyl ester
- AKOS015912410
- SB57844
- FT-0619717
- A811783
- SCHEMBL6475927
- PS-10327
- 5-Pyrimidinecarboxylic acid, 2-hydrazinyl-4-(trifluoromethyl)-, methyl ester
-
- MDL： MFCD00068147
- Inchi： 1S/C7H7F3N4O2/c1-16-5(15)3-2-12-6(14-11)13-4(3)7(8,9)10/h2H,11H2,1H3,(H,12,13,14)
- InChI Key： LIMNVGGTQCLNNP-UHFFFAOYSA-N
- SMILES： FC(C1C(C(=O)OC)=CN=C(NN)N=1)(F)F
Computed Properties
- Exact Mass: 236.05200
- Monoisotopic Mass: 236.052
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 16
- Rotatable Bond Count: 4
- Complexity: 261
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 90.1?2
- Surface Charge: 0
- Tautomer Count: 5
- XLogP3: 0.5
Experimental Properties
- Density: 1.439
- Melting Point: 132 °C
- Boiling Point: 437.7°C at 760 mmHg
- Flash Point: 218.5°C
- Refractive Index: 1.535
- PSA: 90.13000
- LogP: 1.34090
- Vapor Pressure: 0.0±1.1 mmHg at 25°C
Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate Security Information
- Signal Word：warning
- Hazard Statement： Irritant
-
Warning Statement：
P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care - Hazard Category Code： 20/21/22-36/37/38
- Safety Instruction： S26; S36/37/39
-
Hazardous Material Identification：
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
- Safety Term：S26;S36/37/39
- Risk Phrases：R20/21/22
Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 008371-250mg |
5-(Methoxycarbonyl)-4-(trifluoromethyl)pyrimidine-2-hydrazine |
175137-28-7 | 95% | 250mg |
￡67.00 | 2022-03-01 | |
| Fluorochem | 008371-1g |
5-(Methoxycarbonyl)-4-(trifluoromethyl)pyrimidine-2-hydrazine |
175137-28-7 | 95% | 1g |
￡179.00 | 2022-03-01 | |
| Alichem | A089000537-5g |
Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate |
175137-28-7 | 95% | 5g |
$474.24 | 2022-04-02 | |
| Chemenu | CM166281-5g |
Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate |
175137-28-7 | 95% | 5g |
$427 | 2021-08-05 | |
| Apollo Scientific | PC5048-100mg |
Methyl 2-hydrazino-4-(trifluoromethyl)pyrimidine-5-carboxylate |
175137-28-7 | 95% | 100mg |
￡20.00 | 2025-02-21 | |
| Chemenu | CM166281-5g |
Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate |
175137-28-7 | 95%+ | 5g |
$427 | 2023-02-17 | |
| Ambeed | A558057-100mg |
Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate |
175137-28-7 | 95% | 100mg |
$25.0 | 2024-04-22 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBU8697-100mg |
methyl 2-hydrazino-4-(trifluoromethyl)pyrimidine-5-carboxylate |
175137-28-7 | 95% | 100mg |
￥555.0 | 2024-04-23 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBU8697-250mg |
methyl 2-hydrazino-4-(trifluoromethyl)pyrimidine-5-carboxylate |
175137-28-7 | 95% | 250mg |
￥739.0 | 2024-04-23 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBU8697-500mg |
methyl 2-hydrazino-4-(trifluoromethyl)pyrimidine-5-carboxylate |
175137-28-7 | 95% | 500mg |
￥1234.0 | 2024-04-23 |
Methyl 2-hydrazinyl-4-(trifluoromethyl)pyrimidine-5-carboxylate Related Literature
-
Tanya Ostapenko,Peter J. Collings,Samuel N. Sprunt,J. T. Gleeson Soft Matter, 2013,9, 9487-9498
-
Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
-
Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
-
Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
-
Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
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