• 1. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 2. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 3. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes

Comprehensive Overview of (4-bromo-2-nitrophenyl)methanesulfonyl chloride (CAS No. 1595870-36-2)

(4-bromo-2-nitrophenyl)methanesulfonyl chloride (CAS No. 1595870-36-2) is a specialized sulfonyl chloride derivative widely utilized in organic synthesis and pharmaceutical intermediates. This compound features a bromonitrophenyl backbone coupled with a reactive methanesulfonyl chloride group, making it a valuable building block for cross-coupling reactions and heterocyclic compound development. Its unique structure enables applications in drug discovery, material science, and agrochemical research.

The growing demand for high-purity intermediates like (4-bromo-2-nitrophenyl)methanesulfonyl chloride reflects trends in green chemistry and sustainable synthesis. Researchers frequently search for "CAS 1595870-36-2 solubility" or "nitrophenyl sulfonyl chloride applications," highlighting its relevance in catalysis and peptide modification. Recent studies emphasize its role in click chemistry and bioconjugation, aligning with the rise of targeted drug delivery systems.

From a synthetic chemistry perspective, this compound’s electron-withdrawing nitro and bromo groups enhance its reactivity in nucleophilic substitution reactions. Laboratories often inquire about "1595870-36-2 handling precautions" or "methanesulfonyl chloride stability," underscoring the need for proper storage conditions (e.g., anhydrous environments). Its melting point and NMR spectra data are critical for quality control in batch production.

Innovations in flow chemistry have further amplified interest in (4-bromo-2-nitrophenyl)methanesulfonyl chloride, as it enables continuous manufacturing of complex molecules. The compound’s compatibility with microwave-assisted synthesis and photocatalysis positions it as a candidate for high-throughput screening. Searches for "bromo-nitrophenyl derivatives suppliers" or "sulfonylation reagent alternatives" indicate its commercial importance.

In medicinal chemistry, this intermediate contributes to the development of kinase inhibitors and antibody-drug conjugates (ADCs). Its CAS No. 1595870-36-2 is frequently cited in patents related to anticancer agents and anti-inflammatory drugs. The compound’s regioselectivity in reactions with amino acids or heteroaromatics makes it indispensable for structure-activity relationship (SAR) studies.

Environmental considerations drive research into biodegradable sulfonylating agents, though (4-bromo-2-nitrophenyl)methanesulfonyl chloride remains preferred for its high yield and scalability. Analytical techniques like HPLC-MS and FT-IR are essential for verifying its purity, addressing queries such as "how to characterize sulfonyl chlorides." Future applications may expand into polymeric materials and electronic chemicals.

For suppliers and manufacturers, optimizing synthesis routes of CAS 1595870-36-2 to reduce byproduct formation is a priority. The compound’s cost-effectiveness compared to similar aryl sulfonyl chlorides sustains its market demand. Regulatory compliance with REACH and GMP standards ensures its safe use in API production.

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