• 1. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 2. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 3. Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N-glycopeptides??
  Zhizhen Lai,Mo Zhang,Jinyu Zhou,Tianjing Chen,Dan Li,Xuejing Shen,Jia Liu,Jiang Zhou,Zhili Li Analyst, 2021,146, 4261-4267
• 4. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 5. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305

Comprehensive Overview of 7-Bromoquinolin-5-amine (CAS No. 1588440-90-7): Properties, Applications, and Research Insights

7-Bromoquinolin-5-amine (CAS No. 1588440-90-7) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and materials science research. This brominated quinoline derivative features a unique molecular structure, combining a quinoline backbone with a bromine substituent at the 7-position and an amine group at the 5-position. Its structural versatility makes it a valuable intermediate in the synthesis of bioactive molecules, particularly in the development of antimalarial agents, anticancer drugs, and fluorescence probes.

Recent studies highlight the growing demand for 7-Bromoquinolin-5-amine in medicinal chemistry, driven by its role as a building block for drug discovery. Researchers are actively exploring its potential in targeted therapies, especially in the context of kinase inhibitors and GPCR modulators. The compound's electron-rich aromatic system and hydrogen-bonding capacity enable precise molecular interactions, a feature highly sought after in structure-activity relationship (SAR) studies.

From a synthetic perspective, 7-Bromoquinolin-5-amine is often synthesized via Pd-catalyzed cross-coupling reactions or nucleophilic aromatic substitution. Its CAS No. 1588440-90-7 serves as a critical identifier in chemical databases like Reaxys and SciFinder, where users frequently search for quinoline derivatives, brominated amines, or small-molecule libraries. The compound's purity (>98% by HPLC) and stability under inert conditions make it suitable for high-throughput screening (HTS) applications.

In the field of organic electronics, 7-Bromoquinolin-5-amine has emerged as a precursor for light-emitting materials due to its tunable photophysical properties. Its incorporation into OLEDs and sensors is being investigated, aligning with the global push toward sustainable technologies. This dual applicability in life sciences and advanced materials underscores its interdisciplinary relevance.

Frequently asked questions about 7-Bromoquinolin-5-amine include inquiries about its solubility profile (notably in DMSO and dichloromethane), storage conditions (recommended at -20°C under argon), and scalability for industrial production. Analytical techniques such as NMR spectroscopy, mass spectrometry, and X-ray crystallography are routinely employed to characterize this compound, ensuring compliance with Good Laboratory Practice (GLP) standards.

As the scientific community continues to explore quinoline-based therapeutics, 7-Bromoquinolin-5-amine remains a focal point for innovation. Its integration into combinatorial chemistry workflows and AI-driven drug design platforms exemplifies its adaptability to modern research paradigms. With ongoing advancements in green chemistry, efforts to optimize its synthesis via catalytic methods or flow chemistry are expected to gain traction.

In summary, 7-Bromoquinolin-5-amine (CAS No. 1588440-90-7) represents a critical tool for researchers navigating the intersections of drug development, material science, and chemical biology. Its robust applications and evolving methodologies position it as a compound of enduring scientific and industrial value.

• 65340-75-2(4-Amino-8-bromoquinoline)
• 116632-58-7(8-Bromoquinolin-5-amine)
• 350800-81-6(6-Bromo-1H-indol-4-amine)
• 916812-31-2(6-Bromo-N-methylquinolin-4-amine)
• 65340-74-1(4-Amino-7-bromoquinoline)
• 65340-73-0(6-bromoquinolin-4-amine)
• 50358-39-9(6-Bromoquinolin-5-amine)
• 157996-59-3(9-Acridinamine,2-bromo-)
• 89346-39-4(7H-Benzo[c]carbazol-4-amine, 10-bromo-)
• 1134753-48-2(4-Bromo-6-amino Indole Hydrochloride)