• 1. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 2. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 3. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 4. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 5. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan

Comprehensive Overview of 8-Bromoquinolin-5-amine (CAS No. 116632-58-7): Properties, Applications, and Research Insights

8-Bromoquinolin-5-amine (CAS No. 116632-58-7) is a halogenated quinoline derivative that has garnered significant attention in pharmaceutical and material science research. This compound, characterized by its bromine substitution at the 8-position and an amino group at the 5-position, serves as a versatile intermediate in organic synthesis. Its molecular formula, C₉H₇BrN₂, and unique structural features make it valuable for designing heterocyclic compounds with potential biological activity.

Recent studies highlight the growing demand for 8-Bromoquinolin-5-amine in drug discovery, particularly in the development of antimicrobial agents and kinase inhibitors. Researchers are exploring its role in modulating protein-protein interactions, a hot topic in targeted cancer therapies. The compound’s electron-rich quinoline core also makes it a candidate for fluorescence-based sensors, aligning with trends in bioimaging and diagnostic tools.

From a synthetic perspective, CAS 116632-58-7 is often utilized in cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig couplings, to construct complex molecular architectures. Its bromine atom acts as a reactive handle for further functionalization, enabling the creation of libraries for high-throughput screening. This adaptability addresses the pharmaceutical industry’s need for diverse chemical space in lead optimization.

Environmental and sustainability concerns have spurred interest in green chemistry approaches for synthesizing 8-Bromoquinolin-5-amine. Catalytic methods using palladium nanoparticles or photocatalysis are being investigated to reduce waste and energy consumption. Such innovations resonate with the broader push for eco-friendly synthetic protocols, a frequently searched topic among chemists.

Analytical characterization of 8-Bromoquinolin-5-amine typically involves NMR spectroscopy, HPLC, and mass spectrometry to ensure purity and structural integrity. These techniques are critical for quality control, especially when the compound is used in preclinical studies. Discussions on analytical method validation for such intermediates are prevalent in scientific forums, reflecting user interest in reproducible research.

In material science, the compound’s conjugated system contributes to its potential in organic electronics, such as OLEDs or photovoltaic devices. Its ability to coordinate with metals also opens avenues for catalysis and metal-organic frameworks (MOFs), areas gaining traction due to their applications in carbon capture and hydrogen storage.

Safety data sheets emphasize proper handling of 8-Bromoquinolin-5-amine under standard laboratory conditions, though it is not classified as a hazardous material. Researchers frequently search for storage recommendations and compatibility with other reagents, underscoring the importance of practical usage guidelines.

Looking ahead, the integration of AI-driven drug design and computational chemistry tools is expected to accelerate the exploration of 8-Bromoquinolin-5-amine derivatives. Virtual screening and QSAR modeling can predict biological activity, reducing experimental costs—a key concern in R&D efficiency discussions.

In summary, 8-Bromoquinolin-5-amine (CAS No. 116632-58-7) bridges multiple disciplines, from medicinal chemistry to advanced materials. Its adaptability to cutting-edge technologies and alignment with sustainable practices ensure its relevance in contemporary scientific inquiry.

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