• 1. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 2. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 3. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
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• 4. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
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  JGQuintiere

Exploring 6-Bromo-1H-indol-4-amine (CAS No. 350800-81-6): A Versatile Indole Derivative in Modern Research

The compound 6-Bromo-1H-indol-4-amine (CAS No. 350800-81-6) is a brominated indole derivative that has garnered significant attention in pharmaceutical and agrochemical research. With its unique molecular structure, this compound serves as a key intermediate in the synthesis of biologically active molecules. The presence of both a bromo substituent and an amine group at the 4-position of the indole ring makes it a valuable building block for drug discovery and material science applications.

Recent studies highlight the growing interest in indole-based compounds, particularly those with halogen substitutions like 6-Bromo-1H-indol-4-amine. Researchers are exploring its potential in designing novel therapeutics targeting neurological disorders and metabolic diseases. The compound's ability to interact with various biological receptors stems from its electron-rich aromatic system, which is further enhanced by the bromine atom's electronic effects.

In the context of green chemistry trends, synthetic methodologies for 6-Bromo-1H-indol-4-amine have evolved to minimize environmental impact. Catalytic bromination techniques and solvent-free reactions are now being optimized for its production, addressing the pharmaceutical industry's demand for sustainable processes. These advancements align with current searches for "eco-friendly indole synthesis" and "green bromination methods" in scientific databases.

The compound's stability under various conditions makes it particularly useful for high-throughput screening applications. Many researchers investigating "indole scaffold optimization" or "structure-activity relationships" frequently utilize 6-Bromo-1H-indol-4-amine as a reference standard or starting material. Its crystalline form allows for precise characterization using techniques like X-ray diffraction and NMR spectroscopy.

From a commercial perspective, the global market for specialty indole derivatives is expanding rapidly, with 6-Bromo-1H-indol-4-amine appearing in numerous patent applications. Its role in developing selective enzyme inhibitors and receptor modulators has made it a compound of interest for pharmaceutical companies focusing on personalized medicine approaches. This correlates with increasing online searches for "indole-based drug candidates" and "brominated heterocycles in medicine".

Analytical chemists have developed sophisticated methods for quantifying 6-Bromo-1H-indol-4-amine in complex matrices, responding to the need for precise quality control in research settings. The compound's distinct UV-Vis absorption profile enables sensitive detection, making it suitable for studies on "indole metabolism pathways" and "heterocyclic compound analysis". These applications are particularly relevant in academic and industrial laboratories focusing on natural product research.

Recent computational chemistry studies have modeled the electronic properties of 6-Bromo-1H-indol-4-amine, providing insights into its reactivity patterns. Such in silico investigations support the growing field of "computer-aided drug design" where researchers frequently search for "indole DFT calculations" and "halogen bonding in medicinal chemistry". These theoretical approaches complement experimental work, accelerating the discovery of new applications for this versatile compound.

The compound's potential in material science is another area gaining traction. 6-Bromo-1H-indol-4-amine serves as a precursor for conductive polymers and organic semiconductors, aligning with current interests in "organic electronic materials" and "indole-based polymers". Its ability to form stable complexes with transition metals opens possibilities for catalytic systems and advanced materials with tailored properties.

Quality standards for 6-Bromo-1H-indol-4-amine continue to evolve, with pharmacopeial monographs being developed to ensure consistency across research applications. This addresses the frequent search queries about "indole derivative purity standards" and "analytical reference materials". The establishment of rigorous specifications supports reproducible research outcomes in both academic and industrial settings.

Looking forward, the scientific community anticipates new discoveries involving 6-Bromo-1H-indol-4-amine as research into functionalized indoles expands. Its combination of synthetic accessibility and structural versatility positions it as a valuable tool for addressing current challenges in medicinal chemistry and materials development. Ongoing studies continue to reveal novel applications that leverage its unique chemical properties.

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