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  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 2. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 3. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 4. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

N-Acetyl-D-serine (CAS No. 152612-69-6): A Comprehensive Guide to Its Properties and Applications

N-Acetyl-D-serine (CAS No. 152612-69-6) is a specialized amino acid derivative that has garnered significant attention in biochemical and pharmaceutical research. This compound, known for its unique structural properties, serves as a crucial building block in peptide synthesis and drug development. With the increasing focus on custom amino acids and peptide-based therapeutics, N-Acetyl-D-serine has become a subject of interest for researchers and manufacturers alike.

The molecular structure of N-Acetyl-D-serine features an acetyl group attached to the nitrogen atom of D-serine, which distinguishes it from its L-form counterpart. This modification enhances its stability and bioavailability, making it particularly valuable in peptide modification and bioconjugation applications. Recent studies have highlighted its potential in developing targeted drug delivery systems, a hot topic in modern pharmaceutical research.

One of the most searched questions about N-Acetyl-D-serine relates to its role in neurological research. As the scientific community explores novel approaches to neuroprotection and cognitive enhancement, this compound has shown promise in modulating neurotransmitter activity. Its ability to influence NMDA receptor function has sparked discussions in forums and research papers, particularly in the context of neurodegenerative diseases.

In the field of cosmeceuticals, another trending area of interest, N-Acetyl-D-serine has demonstrated potential as a skin-conditioning agent. Its hydrating properties and compatibility with skin proteins make it a candidate for anti-aging formulations, aligning with the growing consumer demand for science-backed skincare ingredients. This application has led to increased queries about its safety profile and dermal absorption characteristics.

The synthesis of N-Acetyl-D-serine typically involves enzymatic resolution or chiral synthesis methods, topics frequently searched by chemistry professionals. Recent advancements in green chemistry have prompted investigations into more sustainable production methods, reflecting the industry's shift toward environmentally friendly processes. Manufacturers are particularly interested in optimizing yield and purity while reducing process waste.

Quality control of N-Acetyl-D-serine remains a critical concern, with analytical techniques such as HPLC and chiral chromatography being essential for verifying its optical purity. The compound's specifications, including residual solvent levels and heavy metal content, are frequently discussed in quality assurance forums, especially among buyers seeking GMP-grade materials for pharmaceutical applications.

Market trends indicate growing demand for N-Acetyl-D-serine in the research chemicals sector, particularly for peptide drug discovery projects. The compound's versatility in structure-activity relationship studies has made it valuable for medicinal chemists exploring new therapeutic targets. This aligns with the current industry focus on personalized medicine and precision therapeutics.

Storage and handling of N-Acetyl-D-serine require attention to moisture sensitivity, a practical consideration often searched by laboratory personnel. Proper desiccation methods and packaging solutions are frequently discussed topics in technical forums, reflecting the compound's hygroscopic nature. These operational aspects are crucial for maintaining product stability during long-term storage.

Recent patent literature reveals innovative applications of N-Acetyl-D-serine in biomaterial engineering, particularly in developing bioactive coatings for medical devices. This emerging application area connects with the broader trend of biocompatible materials in healthcare technology. Researchers are actively investigating its potential to improve implant integration and tissue compatibility.

The global market for N-Acetyl-D-serine continues to expand, driven by increasing R&D investments in biopharmaceuticals and specialty chemicals. Supply chain professionals frequently search for information about reliable suppliers and bulk purchasing options, indicating robust commercial interest. Pricing trends and manufacturing capacity are additional topics of discussion in industry reports.

For researchers working with N-Acetyl-D-serine, understanding its solubility characteristics in various buffer systems is essential for experimental design. This practical consideration generates numerous technical queries, especially regarding its behavior in physiological pH ranges. Such information is critical for formulation scientists developing injectable or oral dosage forms.

Emerging applications in agricultural chemistry represent another developing area for N-Acetyl-D-serine. Preliminary studies suggest potential benefits in plant stress resistance, connecting with the growing interest in sustainable agriculture solutions. This novel application direction has begun appearing in scientific literature and conference presentations, though further validation studies are needed.

Analytical method development for N-Acetyl-D-serine quantification remains an active research area, with particular focus on LC-MS techniques for trace analysis. These methods are crucial for metabolic studies and pharmacokinetic research, addressing common questions about the compound's in vivo behavior and biological fate in therapeutic applications.

The future outlook for N-Acetyl-D-serine appears promising, with potential expansions into diagnostic applications and molecular imaging. As research continues to uncover new properties and applications, this compound is likely to maintain its relevance in multiple scientific disciplines. Ongoing studies exploring its structure-function relationships may reveal additional valuable characteristics for specialized applications.

• 97-14-3(N-Acetyl-DL-serine)
• 110294-55-8(Dismutase, superoxide(human clone pS61-10 copper-zinc subunit protein moiety reduced) N-acetyl-(9CI))
• 16354-58-8(N-Acetyl-L-serine (>90%))
• 184226-42-4(L-Serine,N-(hydroxyacetyl)- (9CI))
• 1115-69-1(N-Acetyl-DL-alanine)
• 687-38-7(Glycyl-DL-serine)
• 7361-43-5(Glycyl-L-serine)
• 97-69-8((2S)-2-acetamidopropanoic acid)
• 19436-52-3(Ac-D-Ala-OH)
• 239106-36-6(L-Serine,N-acetyl-N-methyl-)