• 1. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
• 2. An antioxidant self-healing hydrogel for 3D cell cultures?
  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
• 3. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 4. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 5. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Cyclopropanecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Cyclopropanecarboxylic acids and derivatives Cyclopropanecarboxylic acids

Comprehensive Overview of (1S,2S)-Cyclopropane-1,2-dicarboxylic acid (CAS No. 14590-54-6): Properties, Applications, and Industry Insights

The (1S,2S)-Cyclopropane-1,2-dicarboxylic acid (CAS No. 14590-54-6) is a chiral cyclopropane derivative with significant relevance in pharmaceutical synthesis, agrochemicals, and advanced material science. This compound, characterized by its rigid three-membered ring structure and two carboxyl groups, has garnered attention for its unique stereochemistry and functional versatility. Researchers and industries increasingly seek high-purity (1S,2S)-isomers due to their role as building blocks in asymmetric catalysis and drug intermediates, aligning with the growing demand for enantioselective synthesis.

In recent years, the cyclopropane dicarboxylic acid derivatives market has expanded, driven by trends in green chemistry and sustainable manufacturing. A surge in Google searches for "chiral cyclopropane applications" and "CAS 14590-54-6 suppliers" reflects this interest. The compound’s stability under physiological conditions makes it valuable for designing protease inhibitors and bioactive small molecules, a hotspot in oncology and antiviral research. Notably, its low toxicity profile and biodegradability align with ESG (Environmental, Social, and Governance) goals in chemical production.

From a synthetic perspective, (1S,2S)-Cyclopropane-1,2-dicarboxylic acid serves as a precursor for peptide mimetics and conformationally restricted analogs, addressing challenges in drug bioavailability. Patent analyses reveal its use in next-generation kinase inhibitors, responding to queries like "cyclopropane dicarboxylic acid in drug design". Its crystalline form (melting point ~210°C) and solubility in polar solvents further enhance process scalability, a critical factor for contract manufacturing organizations (CMOs).

Emerging applications include metal-organic frameworks (MOFs), where the compound’s rigid backbone aids in constructing porous materials for CO₂ capture—a trending topic in climate tech. Laboratories also utilize it as a chiral resolving agent, capitalizing on its enantiomeric purity (>99% ee) to separate racemic mixtures. This dual functionality positions CAS No. 14590-54-6 as a multipurpose scaffold, bridging gaps between academia and industrial R&D.

Quality control protocols for 14590-54-6 emphasize HPLC and NMR validation, ensuring compliance with ICH Q7 guidelines. Suppliers highlighting GMP-grade (1S,2S)-Cyclopropane-1,2-dicarboxylic acid witness higher engagement, as pharmaceutical companies prioritize regulatory-ready materials. The compound’s storage stability (2-8°C under inert atmosphere) and compatibility with automated synthesis platforms further bolster its adoption in high-throughput screening.

In conclusion, (1S,2S)-Cyclopropane-1,2-dicarboxylic acid exemplifies the convergence of structural innovation and practical utility. Its alignment with AI-driven molecular design trends and circular economy principles ensures sustained relevance. For researchers exploring stereoselective cyclopropanation or green solvent compatibility, this compound offers a robust toolkit to address modern chemical challenges.

• 103425-17-8(rac-(1R,2S)-2-formylcyclopropane-1-carboxylic acid)
• 58616-95-8((+/-) trans-1,2-cyclopropane dicarboxylic acid)
• 58650-45-6(Cyclopropanecarboxylicacid, 2-pentyl-, (1R,2S)-rel-)
• 5075-48-9(Cyclopropanecarboxylicacid, 2-pentyl-, (1R,2R)-rel-)
• 1489-58-3(Cyclopropane-1,2-dicarboxylic acid)
• 6202-94-4(trans-2-methylcyclopropanecarboxylic acid)
• 68850-10-2(2-Ethylcyclopropanecarboxylic acid)
• 6142-57-0(cis-2-Methylcyclopropanecarboxylic acid)
• 29555-02-0(2-Methylcyclopropanecarboxylic acid)
• 23772-94-3(2,2-dicyclopropylacetic acid)