Production Method 1

24424-99-5

119479-49-1

145166-06-9

Reaction Conditions

Reference

Highly enantioselective direct organocatalytic α-chlorination of ketones

Marigo, Mauro; Bachmann, Stephan; Halland, Nis; Braunton, Alan; Jorgensen, Karl Anker, Angewandte Chemie, 2004, 43(41), 5507-5510

Production Method 2

24424-99-5

216394-07-9

145166-06-9

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran
1.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  6 h, 25 psi, rt

Reference

SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa

Qiao, Jennifer X.; Chang, Chong-Hwan; Cheney, Daniel L.; Morin, Paul E.; Wang, Gren Z.; et al, Bioorganic & Medicinal Chemistry Letters, 2007, 17(16), 4419-4427

Production Method 3

121282-70-0

145166-06-9

156318-44-4

Reaction Conditions

1.1 Reagents: Triacylglycerol lipase Solvents: Vinyl acetate

Reference

Enzymatic method of preparation of optically active trans-2-amino cyclohexanol derivatives

Ursini, A.; Maragni, P.; Bismara, C.; Tamburini, B., Synthetic Communications, 1999, 29(8), 1369-1377

Production Method 4

145166-06-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  10 h, rt

Reference

Chemoenzymatic preparation of optically active trans- and cis-cyclohex-4-ene-1,2-diamine and trans-6-aminocyclohex-3-enol derivatives

Quijada, F. Javier; Rebolledo, Francisca; Gotor, Vicente, Tetrahedron, 2012, 68(37), 7670-7674

Production Method 5

24424-99-5

98361-56-9

145166-06-9

Reaction Conditions

1.1 Reagents: Ammonium formate Catalysts: Palladium Solvents: Methanol
1.2 Solvents: Dichloromethane

Reference

Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors

Nagata, Tsutomu; Yoshino, Toshiharu; Haginoya, Noriyasu; Yoshikawa, Kenji; Isobe, Yumiko; et al, Bioorganic & Medicinal Chemistry Letters, 2007, 17(16), 4683-4688

Production Method 6

764659-69-0

145166-06-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  48 h, 4 atm, rt

Reference

Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists

Okano, Masahiko; Mito, Jun; Maruyama, Yasufumi; Masuda, Hirofumi; Niwa, Tomoko; et al, Bioorganic & Medicinal Chemistry, 2009, 17(1), 119-132

Production Method 7

24424-99-5

119479-49-1

145166-06-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Platinum dioxide Solvents: Ethyl acetate ;  3.5 h, 35 - 40 psi, rt
1.2 -

Reference

Synthesis and Evaluation of (1S,2R/1R,2S)-Aminocyclohexylglycyl PNAs as Conformationally Preorganized PNA Analogues for DNA/RNA Recognition

Govindaraju, T.; Kumar, Vaijayanti A.; Ganesh, Krishna N., Journal of Organic Chemistry, 2004, 69(6), 1858-1865

tert-butyl N-[(1S,2S)-2-hydroxycyclohexyl]carbamate Raw materials

• Di-tert-butyl dicarbonate
• Cyclohexanol, 2-azido-, (1S,2S)-
• tert-butyl N-[trans-2-hydroxycyclohexyl]carbamate
• (1S,2S)-2-((R)-1-Phenylethylamino)cyclohexanol
• tert-butyl [(1S,2S)-2-(benzyloxy)cyclohexyl]carbamate
• (1S,2S)-2-(Benzyloxy)cyclohexanamine

tert-butyl N-[(1S,2S)-2-hydroxycyclohexyl]carbamate Preparation Products

• Carbamic acid, [(1R,2R)-2-(acetyloxy)cyclohexyl]-, 1,1-dimethylethyl ester (156318-44-4)
• tert-butyl N-[(1S,2S)-2-hydroxycyclohexyl]carbamate (145166-06-9)

• 1. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 2. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 3. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 4. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
• 5. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Secondary alcohols
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alcohols and polyols Secondary alcohols

• 155837-14-2(tert-butyl ((1R,2R)-2-Hydroxycyclopentyl)carbamate)
• 511268-25-0(Carbamic acid, N-[(1S)-1-(2-amino-1-hydroxyethyl)pentyl]-, 1,1-dimethylethyl ester)
• 291533-28-3(tert-butyl N-[(1R,2S)-2-hydroxycyclohexyl]carbamate)
• 121282-70-0(tert-butyl N-[trans-2-hydroxycyclohexyl]carbamate)
• 214679-17-1(tert-butyl N-[(1S,2R)-2-hydroxycyclohexyl]carbamate)
• 145106-43-0(tert-butyl N-[(1S,2S)-2-hydroxycyclopentyl]carbamate)
• 155837-16-4(tert-butyl N-[cis-2-hydroxycyclopentyl]carbamate)
• 155975-19-2(tert-butyl N-[(1R,2R)-2-hydroxycyclohexyl]carbamate)
• 599207-03-1(Carbamic acid, [(1S)-1-[(1R)-1-hydroxyethyl]butyl]-, 1,1-dimethylethyl ester)
• 454170-16-2(tert-butyl N-[(1R,2R)-2-hydroxycyclopentyl]carbamate)