Production Method 1

89283-48-7

1450822-23-7

872511-30-3

Reaction Conditions

1.1 Reagents: m-Chloroperbenzoic acid Solvents: Dichloromethane ;  20 h, 0 °C → rt
2.1 Solvents: Tetrahydrofuran ;  70 min, -70 °C → rt

Reference

Chemoselective reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and related electrophiles with amines

Baiazitov, Ramil; et al, Synthesis, 2013, 45(13), 1764-1784

Production Method 2

89283-46-5

1450822-23-7

872511-30-3

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  70 min, -70 °C → rt

Reference

Chemoselective reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and related electrophiles with amines

Baiazitov, Ramil; et al, Synthesis, 2013, 45(13), 1764-1784

4-Pyrimidinamine, N-ethyl-6-(methylsulfonyl)- Raw materials

• 4-chloro-6-methylsulfanyl-pyrimidine
• 4-Chloro-6-(methylsulfonyl)pyrimidine

4-Pyrimidinamine, N-ethyl-6-(methylsulfonyl)- Preparation Products

• 6-chloro-N-ethylpyrimidin-4-amine (872511-30-3)
• 4-Pyrimidinamine, N-ethyl-6-(methylsulfonyl)- (1450822-23-7)

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