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• 2. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
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• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Prenol lipids Triterpene saponins
• Triterpenoids

Hederacoside C (CAS No. 14216-03-6): A Comprehensive Overview

Hederacoside C (CAS No. 14216-03-6) is a naturally occurring triterpenoid saponin found in various plants, particularly in the genus Aquilegia and Ilex. This compound has garnered significant attention in the scientific community due to its diverse biological activities and potential therapeutic applications. In this comprehensive overview, we will delve into the chemical structure, pharmacological properties, and recent research findings related to Hederacoside C.

Chemical Structure and Properties

Hederacoside C is a complex molecule with a molecular formula of C₅₇H₉₀O₂₄. It belongs to the class of triterpenoid saponins, which are characterized by their glycosidic bonds and triterpenoid aglycones. The aglycone of Hederacoside C is hederagenin, a pentacyclic triterpene that contributes to its unique biological properties. The glycosidic moiety consists of multiple sugar units, including glucose and rhamnose, which enhance its solubility and bioavailability.

The molecular weight of Hederacoside C is approximately 1137.28 g/mol. It is a white crystalline powder that is soluble in water and methanol but insoluble in non-polar solvents such as hexane. These properties make it suitable for various pharmaceutical formulations and research applications.

Pharmacological Activities

Hederacoside C has been extensively studied for its wide range of pharmacological activities, including anti-inflammatory, antioxidant, anti-cancer, and cardioprotective effects. Recent research has provided valuable insights into the mechanisms underlying these activities.

Anti-inflammatory Activity: Studies have shown that Hederacoside C exhibits potent anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines such as TNF-α and IL-6. It also suppresses the activation of nuclear factor-kappa B (NF-κB), a key transcription factor involved in inflammation. These findings suggest that Hederacoside C could be a promising candidate for the treatment of inflammatory diseases.

Antioxidant Activity: Hederacoside C has been found to possess strong antioxidant properties, which help in scavenging free radicals and reducing oxidative stress. This activity is attributed to its ability to upregulate the expression of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT). The antioxidant potential of Hederacoside C makes it a valuable component in formulations designed to combat oxidative damage.

Anti-cancer Activity: strong>: Research has demonstrated that Hederacoside C strong > exhibits significant anti-cancer effects by inducing apoptosis and inhibiting cell proliferation in various cancer cell lines. It has been shown to target multiple signaling pathways involved in cancer progression, including the PI3K/Akt and MAPK pathways. These findings highlight the potential of < strong >Hederacoside C< / strong > as a novel therapeutic agent for cancer treatment. p > < p >< strong >Cardioprotective Effects:< / strong > Studies have indicated that< strong >Hederacoside C< / strong > has cardioprotective properties by improving myocardial function and reducing myocardial injury. It has been shown to enhance cardiac contractility and reduce oxidative stress in cardiac tissues. These effects make< strong >Hederacoside C< / strong > a promising candidate for the prevention and treatment of cardiovascular diseases. p > < p >< strong >Recent Research Findings< / strong > p > < p >< strong >Hederacoside C< / strong > continues to be an active area of research, with new studies providing deeper insights into its mechanisms of action and potential therapeutic applications. For instance, a recent study published in the Journal of Ethnopharmacology investigated the neuroprotective effects of< strong >Hederacoside C< / strong > in an animal model of Parkinson's disease. The results showed that< strong >Hederacoside C< / strong > significantly reduced dopaminergic neuron loss and improved motor function by modulating neuroinflammatory responses. p > < p >Another study published in the Journal of Agricultural and Food Chemistry explored the anti-diabetic potential of< strong >Hederacoside C< / strong >. The researchers found that it effectively lowered blood glucose levels and improved insulin sensitivity in diabetic mice by activating AMP-activated protein kinase (AMPK) signaling pathways. p > < p >< strong >Conclusion< / strong > p > < p >< strong >Hederacoside C (CAS No. 14216-03-6)< / strong > is a multifaceted compound with a wide range of biological activities that hold promise for various therapeutic applications. Its anti-inflammatory, antioxidant, anti-cancer, cardioprotective, neuroprotective, and anti-diabetic properties make it an attractive candidate for further research and development. As ongoing studies continue to uncover new mechanisms and applications,< strong >Hederacoside C< / strong > is likely to play an increasingly important role in both pharmaceutical formulations and clinical settings. p > article > response >

• 57092-40-7(Olean-12-en-28-oic acid, 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl)oxy]-23-hydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-O-[O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-(1→2)]-β-D-glucopyranosyl ester, (3β,4α)- (9CI))
• 123597-11-5(Olean-12-en-28-oic acid, 3,23-bis(β-D-glucopyranosyloxy)-, 3-O-β-D-glucopyranosyl-α-L-arabinopyranosyl ester, (3β,4α)- (9CI))
• 162857-69-4(Olean-12-en-28-oic acid, 3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-2,23-dihydroxy-, O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-β-D-glucopyranosyl ester, (2β,3β,4α)-)
• 89412-81-7(Olean-12-en-28-oic acid, 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl)oxy]-, 4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl ester, (3β)-)
• 68027-14-5(Hederacolchiside F)
• 95262-53-6(Olean-12-en-28-oicacid, 2,3-dihydroxy-, O-b-D-glucopyranosyl-(1&reg;6)-O-b-D-glucopyranosyl-(1&reg;2)-b-D-glucopyranosyl ester, (2a,3b)- (9CI))
• 942997-00-4([(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-[(2S,3R,4S,5R)-4,5-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate)
• 89412-80-6(Olean-12-en-28-oic acid, 3-[[4-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-, 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl ester, (3β)-)
• 132284-03-8([(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)oxan-2-yl] (4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[(2S,3R,4S,5S)-5-hydroxy-3,4-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate)
• 125265-68-1(Asiaticoside B)