Production Method 1

19398-47-1

1404453-61-7

13220-33-2

89487-67-2

Reaction Conditions

1.1 Solvents: Water ;  4 - 5 min, cooled; 16 h, 100 °C

Reference

Carry Over of Impurities: A Detailed Exemplification for Glycopyrrolate (NVA237)

Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; et al, Organic Process Research & Development, 2012, 16(11), 1754-1769

2-Butanol, 1,4-bis(methylamino)- Raw materials

• 1,4-Dibromo-2-butanol

2-Butanol, 1,4-bis(methylamino)- Preparation Products

• 1-Methyl-3-pyrrolidinol (13220-33-2)
• 2-Butanol, 1,4-bis(methylamino)- (1404453-61-7)
• N-methyltetrahydrofuran-3-amine (89487-67-2)

• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
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• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
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• 5. Enantiocontrolled construction of sistodiolynne, an unusual polyketide from the wood-decay fungus Sistrema raduloides
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