Cas no 14001-66-2 (5-Bromo-2-methoxypyrimidine)

5-Bromo-2-methoxypyrimidine is a heterocyclic compound featuring a pyrimidine core substituted with a bromine atom at the 5-position and a methoxy group at the 2-position. This structure makes it a versatile intermediate in organic synthesis, particularly in pharmaceutical and agrochemical applications. Its reactive bromine moiety facilitates cross-coupling reactions, such as Suzuki or Buchwald-Hartwig couplings, enabling the introduction of diverse functional groups. The methoxy group enhances stability and influences electronic properties, making it useful in the design of bioactive molecules. The compound is characterized by high purity and consistent performance, ensuring reliability in research and industrial processes.
5-Bromo-2-methoxypyrimidine structure
5-Bromo-2-methoxypyrimidine structure
Product Name:5-Bromo-2-methoxypyrimidine
CAS No:14001-66-2
MF:C5H5BrN2O
MW:189.009999990463
MDL:MFCD04973351
CID:49587
PubChem ID:139657
Update Time:2025-06-08

5-Bromo-2-methoxypyrimidine Chemical and Physical Properties

Names and Identifiers

    • 5-Bromo-2-methoxypyrimidine
    • 2-methoxy-5-bromopyrimidine
    • 2-Methoxy-5-brom-pyrimidin
    • 5-bromo-2-methoxy-pyrimidine
    • 5-BROMO-2-METHOXYPYRIMIDINE 97
    • Bromomethoxypyrimidine
    • 5-Bromo-22-methoxypyrimidine
    • 5-Bromo-2-methoxy-1,3-diazine
    • 2-Methoxy-5-broMopyriMidine(5-BroMo-2-MethoxypyriMidine)
    • 5-BROMO-2-METHOXYPYRIMIDINE 97
    • 5-Bromo-2-methoxypyrimidine 98%
    • SCHEMBL322342
    • AB21286
    • FT-0648938
    • Q-102307
    • FS-1433
    • B3521
    • DWVCZDMMGYIULX-UHFFFAOYSA-N
    • AM20080301
    • AKOS005257525
    • SY007743
    • DTXSID10161212
    • Pyrimidine,5-bromo-2-methoxy-
    • AC-22793
    • Pyrimidine, 5-bromo-2-methoxy-
    • 5-Bromo-2-methoxypyrimidine, 97%
    • CS-M3404
    • 5-bromo-2-(methyloxy)pyrimidine
    • EN300-105349
    • 14001-66-2
    • MFCD04973351
    • A3022
    • 1-Bromo-4-(trifluoromethoxy)benzene,98%
    • DB-031849
    • MDL： MFCD04973351
    • Inchi： 1S/C5H5BrN2O/c1-9-5-7-2-4(6)3-8-5/h2-3H,1H3
    • InChI Key： DWVCZDMMGYIULX-UHFFFAOYSA-N
    • SMILES： BrC1C=NC(=NC=1)OC

Computed Properties

  • Exact Mass: 187.95900
  • Monoisotopic Mass: 187.959
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 9
  • Rotatable Bond Count: 1
  • Complexity: 83
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 1.2
  • Topological Polar Surface Area: 35A^2

Experimental Properties

  • Color/Form: White to Yellow Solid
  • Density: 1.628
  • Melting Point: 56.0 to 60.0 deg-C
  • Boiling Point: 259.8±32.0 °C at 760 mmHg
  • Flash Point: 110.9℃
  • Refractive Index: 1.546
  • PSA: 35.01000
  • LogP: 1.24770
  • Solubility: Not available

5-Bromo-2-methoxypyrimidine Security Information

  • Symbol: GHS07
  • Prompt：warning
  • Signal Word：Warning
  • Hazard Statement： H302,H317
  • Warning Statement： P280
  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：3
  • Hazard Category Code： 22-43
  • Safety Instruction： S37/39
  • Hazardous Material Identification： Xn
  • Storage Condition：Sealed in dry,Room Temperature
  • Risk Phrases：R22; R43
  • Safety Term：S37/39

5-Bromo-2-methoxypyrimidine Customs Data

  • HS CODE：2933599090
  • Customs Data：

    China Customs Code:

    2933599090

    Overview:

    2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-Bromo-2-methoxypyrimidine Pricemore >>

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5-Bromo-2-methoxypyrimidine Production Method

5-Bromo-2-methoxypyrimidine Suppliers

Amadis Chemical Company Limited
Gold Member
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(CAS:14001-66-2)5-Bromo-2-methoxypyrimidine
Order Number:A3022
Stock Status:in Stock
Quantity:100g/500g
Purity:99%
Pricing Information Last Updated:Monday, 2 September 2024 16:03
Price ($):150.0/526.0
Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:14001-66-2)5-溴-2-甲氧基嘧啶
Order Number:LE3442862
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:43
Price ($):discuss personally

5-Bromo-2-methoxypyrimidine Related Literature

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Additional information on 5-Bromo-2-methoxypyrimidine

Comprehensive Guide to 5-Bromo-2-methoxypyrimidine (CAS No. 14001-66-2): Properties, Applications, and Industry Insights

5-Bromo-2-methoxypyrimidine (CAS No. 14001-66-2) is a halogenated pyrimidine derivative that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its bromine substitution and methoxy functional group, serves as a versatile intermediate in organic synthesis. Its molecular formula, C5H5BrN2O, and unique structural features make it invaluable for constructing complex molecules, particularly in drug discovery and material science.

In recent years, the demand for heterocyclic compounds like 5-Bromo-2-methoxypyrimidine has surged due to their role in developing kinase inhibitors and antiviral agents. Researchers frequently search for "pyrimidine derivatives in drug design" or "brominated heterocycles synthesis," reflecting the compound's relevance in cutting-edge therapeutic applications. Its compatibility with cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig, further enhances its utility in modular chemistry.

The physicochemical properties of 5-Bromo-2-methoxypyrimidine include a melting point range of 60–65°C and moderate solubility in polar organic solvents like dimethyl sulfoxide (DMSO) and methanol. These traits are critical for laboratory handling and industrial-scale processes. Analytical techniques such as HPLC, NMR, and mass spectrometry are commonly employed to verify its purity, a topic often queried in "how to analyze bromopyrimidines" searches.

From an industrial perspective, 5-Bromo-2-methoxypyrimidine is pivotal in synthesizing crop protection chemicals and electronic materials. Its incorporation into OLEDs and organic semiconductors aligns with the growing interest in "sustainable material chemistry." Manufacturers emphasize green synthesis routes to reduce environmental impact, addressing concerns highlighted in "eco-friendly bromination methods" trends.

Regulatory compliance and REACH certification for 14001-66-2 are frequently discussed topics, ensuring safe global trade. The compound's stability under standard storage conditions (2–8°C, inert atmosphere) makes it a reliable choice for long-term projects. For researchers exploring "scalable pyrimidine production," this compound offers a balance of reactivity and shelf-life.

Innovations in flow chemistry and catalysis have further optimized the synthesis of 5-Bromo-2-methoxypyrimidine, reducing byproducts and energy consumption. Such advancements resonate with queries like "continuous processing for heterocycles" and "catalytic bromination techniques," underscoring the intersection of efficiency and sustainability.

In summary, 5-Bromo-2-methoxypyrimidine (CAS No. 14001-66-2) exemplifies the synergy between structural specificity and broad applicability. Its role in life sciences and advanced materials continues to evolve, driven by interdisciplinary research and eco-conscious methodologies. As the scientific community prioritizes "precision molecular engineering," this compound remains a cornerstone for innovation.

14001-66-2 (5-Bromo-2-methoxypyrimidine) Related Products

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Amadis Chemical Company Limited
(CAS:14001-66-2)5-Bromo-2-methoxypyrimidine
A3022
Purity:99%/99%
Quantity:100g/500g
Price ($):150.0/526.0
Email
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:14001-66-2)5-溴-2-甲氧基嘧啶
LE3442862
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry
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