Cas no 1354621-59-2 ((3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine)

(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine is a chiral piperidine derivative with a defined stereochemistry at the 3- and 4-positions, making it a valuable intermediate in pharmaceutical and organic synthesis. Its rigid bicyclic structure and benzyl substitution enhance its utility in asymmetric synthesis and medicinal chemistry applications. The compound's high stereochemical purity ensures consistent reactivity, particularly in the development of bioactive molecules. Its amine functionality allows for further derivatization, enabling the construction of complex scaffolds. This compound is particularly advantageous for researchers requiring precise stereocontrol in the synthesis of ligands, catalysts, or drug candidates. Proper handling under inert conditions is recommended due to its sensitivity.
(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine structure
1354621-59-2 structure
Product Name:(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine
CAS No:1354621-59-2
MF:C14H22N2
MW:218.337883472443
MDL:MFCD09878607
CID:1081536
Update Time:2025-05-28

(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine Chemical and Physical Properties

Names and Identifiers

    • (3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine
    • (3S,4S)-1-Benzyl-N,4-dimethyl-3-piperidinamine
    • (3S,4S)-(1-Benzyl-4-methyl-piperidin-3-yl)-methyl-amine
    • MDL： MFCD09878607
    • Inchi： 1S/C14H22N2/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13/h3-7,12,14-15H,8-11H2,1-2H3/t12-,14+/m0/s1
    • InChI Key： NVKDDQBZODSEIN-GXTWGEPZSA-N
    • SMILES： N1(CC2C=CC=CC=2)CC[C@H](C)[C@@H](C1)NC

Computed Properties

  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 3

Experimental Properties

  • Density: 1.00±0.1 g/cm3 (20 oC 760 Torr),
  • Boiling Point: 302.6±35.0 oC (760 Torr),
  • Flash Point: 107.4±16.9 oC,
  • Solubility: Slightly soluble (5.5 g/l) (25 o C),

(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.
60R0748-1g
(3S,4S)-(1-Benzyl-4-methyl-piperidin-3-yl)-methyl-amine
 1354621-59-2 97%
1g
 15943.2CNY 2021-05-07
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.
60R0748-5g
(3S,4S)-(1-Benzyl-4-methyl-piperidin-3-yl)-methyl-amine
 1354621-59-2 97%
5g
 58345.32CNY 2021-05-07
SHANG HAI XIAN DING Biotechnology Co., Ltd.
TT339-1g
(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine
 1354621-59-2 95+%
1g
 267CNY 2021-05-08
SHANG HAI XIAN DING Biotechnology Co., Ltd.
TT339-5g
(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine
 1354621-59-2 95+%
5g
 928CNY 2021-05-08
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
S11430-250mg
(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine
 1354621-59-2
250mg
 ￥168.0 2021-09-07
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
S11430-1g
(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine
 1354621-59-2
1g
 ￥388.0 2021-09-07
abcr
AB443130-1 g
(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine, 95%; .
 1354621-59-2 95%
1g
 €196.00 2023-07-18
abcr
AB443130-5 g
(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine, 95%; .
 1354621-59-2 95%
5g
 €655.00 2023-07-18
abcr
AB443130-10 g
(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine, 95%; .
 1354621-59-2 95%
10g
 €838.60 2023-07-18
Ambeed
A178970-100mg
(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine
 1354621-59-2 97%
100mg
 $30.0 2024-04-24

(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Titanium isopropoxide Solvents: Methanol ;  0 - 15 °C; 1 h, 5 - 15 °C
1.2 Reagents: Sodium borohydride ;  1 h, 5 - 15 °C
Reference
An Improved and Efficient Process for the Preparation of Tofacitinib Citrate
Patil, Yogesh S.; Bonde, Nilesh L.; Kekan, Ankush S.; Sathe, Dhananjay G.; Das, Arijit, Organic Process Research & Development, 2014, 18(12), 1714-1720

(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine Raw materials

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(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine Related Literature

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