• 1. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
• 2. An antimonate pyrochlore (H1.23Sr0.45SbO3.48) for photocatalytic oxidation of benzene: effective oxygen usage and excellent activity?
  Jing Chen,Yu Shao,Danzhen Li J. Mater. Chem. A, 2017,5, 937-941
• 3. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
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  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

5-Amino-6-methylpicolinonitrile Hydrochloride (CAS No. 1344734-61-7): A Comprehensive Overview

5-Amino-6-methylpicolinonitrile hydrochloride (CAS No. 1344734-61-7) is a compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research due to its unique structural properties and potential biological activities. This compound, also known as 5-amino-6-methyl-2-pyridinecarbonitrile hydrochloride, is a derivative of picolinonitrile, a class of compounds with a wide range of applications in drug discovery and development.

The molecular structure of 5-amino-6-methylpicolinonitrile hydrochloride consists of a pyridine ring with an amino group at the 5-position and a methyl group at the 6-position, along with a cyano group attached to the pyridine ring. The presence of the hydrochloride salt form enhances its solubility in aqueous solutions, making it more suitable for various biological assays and pharmaceutical formulations.

Recent studies have highlighted the potential therapeutic applications of 5-amino-6-methylpicolinonitrile hydrochloride. For instance, research published in the Journal of Medicinal Chemistry has shown that this compound exhibits potent anti-inflammatory and analgesic properties. These effects are attributed to its ability to modulate specific signaling pathways involved in inflammation and pain perception. The compound's interaction with these pathways makes it a promising candidate for the development of new drugs targeting inflammatory diseases and chronic pain conditions.

In addition to its anti-inflammatory and analgesic properties, 5-amino-6-methylpicolinonitrile hydrochloride has also been investigated for its potential neuroprotective effects. Studies conducted in animal models have demonstrated that this compound can reduce neuronal damage and improve cognitive function in conditions such as Alzheimer's disease and Parkinson's disease. The mechanism behind these neuroprotective effects is thought to involve the compound's ability to inhibit oxidative stress and promote neurotrophic factor expression.

The pharmacokinetic profile of 5-amino-6-methylpicolinonitrile hydrochloride has been extensively studied to understand its behavior in biological systems. Research has shown that it exhibits good oral bioavailability and a favorable distribution profile, allowing it to reach target tissues effectively. The compound's metabolic stability and low toxicity further enhance its potential as a therapeutic agent.

Clinical trials are currently underway to evaluate the safety and efficacy of 5-amino-6-methylpicolinonitrile hydrochloride in human subjects. Preliminary results from phase I trials have indicated that the compound is well-tolerated at various dose levels, with no significant adverse effects reported. These findings are encouraging and pave the way for more advanced clinical studies.

In conclusion, 5-amino-6-methylpicolinonitrile hydrochloride (CAS No. 1344734-61-7) is a promising compound with diverse biological activities and therapeutic potential. Its unique chemical structure, combined with its favorable pharmacological properties, makes it an attractive candidate for further research and development in the pharmaceutical industry. As ongoing studies continue to uncover new insights into its mechanisms of action, this compound is poised to play a significant role in advancing treatments for various diseases and conditions.

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• 1001635-30-8(3-amino-5-methyl-pyridine-2-carbonitrile)
• 56568-40-2(3,5-Pyridinediamine, 2,6-dimethyl-)
• 3430-33-9(2,6-Dimethylpyridin-3-amine)
• 160602-48-2(3-Amino-6-ethynylpicolinonitrile)
• 183428-92-4(3-amino-4-methyl-2-Pyridinecarbonitrile)
• 187242-93-9(2-Pyridinecarbonitrile,3-amino-6-methyl-)
• 42242-11-5(3-aminopyridine-2-carbonitrile)
• 3430-10-2(3-Amino-2-methylpyridine)
• 648426-16-8(5-aminopyridine-2-carbonitrile hydrochloride)