• 1. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584
• 2. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 3. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 4. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 5. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554

3-Amino-4-Methyl-2-Pyridinecarbonitrile (CAS No. 183428-92-4): A Comprehensive Overview

3-Amino-4-methyl-2-pyridinecarbonitrile, also known by its CAS registry number CAS No. 183428-92-4, is a versatile organic compound that has garnered significant attention in the fields of organic synthesis, materials science, and pharmacology. This compound is characterized by its unique structure, which features a pyridine ring substituted with an amino group at the 3-position, a methyl group at the 4-position, and a cyano group at the 2-position. These functional groups impart the molecule with distinctive chemical properties, making it a valuable building block in various chemical reactions and applications.

The synthesis of 3-amino-4-methyl-2-pyridinecarbonitrile has been extensively studied, with researchers exploring various methodologies to optimize its production. Recent advancements have focused on improving reaction efficiency and yield through the use of novel catalysts and reaction conditions. For instance, studies have demonstrated that employing microwave-assisted synthesis can significantly accelerate the formation of this compound while maintaining high purity levels. Such innovations underscore the compound's importance in both academic and industrial settings.

In terms of applications, 3-amino-4-methyl-2-pyridinecarbonitrile has found utility in the development of advanced materials, particularly in the realm of coordination chemistry. The amino and cyano groups on the pyridine ring serve as excellent ligands for metal ions, enabling the creation of metalloorganic frameworks (MOFs) with potential applications in gas storage, catalysis, and sensing technologies. Recent research has highlighted its ability to form stable MOFs with exceptional surface areas and pore structures, making it a promising candidate for next-generation materials.

Beyond materials science, this compound has also shown potential in medicinal chemistry. Its structural features make it an attractive lead compound for drug discovery efforts targeting various therapeutic areas. For example, studies have explored its role as a scaffold for designing inhibitors of key enzymes involved in cancer progression. The methyl group at the 4-position contributes to lipophilicity, enhancing bioavailability, while the amino group provides sites for further functionalization to optimize pharmacokinetic properties.

The latest research on CAS No. 183428-92-4 has delved into its electronic properties, particularly when incorporated into conjugated systems. By modifying the substituents on the pyridine ring or combining it with other aromatic systems, scientists have been able to tune its electronic characteristics for applications in optoelectronics and photovoltaics. These findings suggest that 3-amino-4-methyl-2-pyridinecarbonitrile could play a pivotal role in developing efficient organic semiconductors.

In conclusion, 3-amino-4-methyl-2-pyridinecarbonitrile (CAS No. 183428-92) stands out as a multifaceted compound with a wide array of applications across diverse scientific disciplines. Its unique structure and functional groups continue to drive innovative research, positioning it as a key player in advancing modern chemistry and material science.

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