• 1. Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9–39) in a normoglycemic mouse model
  T. C. Haufe,A. D. Gilley,K. M. Goodrich,C. M. Ryan,A. T. Smithson,M. W. Hulver,D. Liu,A. P. Neilson Food Funct. 2016 7 2692

• Solvents and Organic Chemicals Organic Compounds Organic Polymers Polypeptides Polypeptides
• Solvents and Organic Chemicals Organic Compounds Organic Polymers Polypeptides

Exendin(9-39) amide: A Comprehensive Guide to Its Properties and Applications

Exendin(9-39) amide (CAS No. 133514-43-9) is a synthetic peptide that has garnered significant attention in the field of endocrinology and metabolic research. This 31-amino acid peptide is derived from exendin-4, a naturally occurring hormone found in the saliva of the Gila monster. As a competitive antagonist of the glucagon-like peptide-1 receptor (GLP-1R), Exendin(9-39) amide plays a crucial role in modulating insulin secretion and glucose metabolism, making it a valuable tool for scientific studies.

The growing interest in Exendin(9-39) amide is driven by its potential applications in understanding type 2 diabetes, obesity, and other metabolic disorders. Researchers are particularly intrigued by its ability to block the effects of GLP-1, a hormone that stimulates insulin release. This property makes it an essential compound for investigating the mechanisms of glucose homeostasis and developing novel therapeutic strategies.

One of the most frequently asked questions about Exendin(9-39) amide is its mechanism of action. Unlike exendin-4, which acts as a GLP-1R agonist, Exendin(9-39) amide binds to the receptor without activating it, effectively inhibiting the downstream signaling pathways. This unique characteristic has made it a popular choice for preclinical studies aimed at elucidating the role of GLP-1R in various physiological processes.

In recent years, the demand for Exendin(9-39) amide has surged due to its relevance in cutting-edge research areas such as gut-brain axis signaling and neuroprotection. Studies have shown that GLP-1R is expressed not only in pancreatic cells but also in the central nervous system, suggesting a broader role for this receptor in regulating appetite, cognition, and even neurodegenerative diseases like Alzheimer's and Parkinson's.

Another hot topic surrounding Exendin(9-39) amide is its potential use in precision medicine. With the rise of personalized healthcare, researchers are exploring how this peptide can be tailored to individual patient profiles to optimize metabolic outcomes. For instance, it may help identify subsets of diabetic patients who are less responsive to GLP-1R agonists, paving the way for more targeted therapies.

The synthesis and purification of Exendin(9-39) amide require advanced techniques to ensure high purity and bioactivity. Most commercially available preparations are produced using solid-phase peptide synthesis (SPPS), followed by rigorous quality control measures such as HPLC and mass spectrometry. These stringent protocols guarantee that researchers receive a reliable and consistent product for their experiments.

As the scientific community continues to uncover the multifaceted roles of GLP-1R, the importance of Exendin(9-39) amide as a research tool is expected to grow. Its applications extend beyond diabetes and obesity, with emerging evidence pointing to its utility in cardiovascular research, inflammation, and even cancer biology. This versatility underscores the need for continued investment in peptide-based research and development.

For those searching for Exendin(9-39) amide suppliers or Exendin(9-39) amide price, it is essential to choose reputable vendors who provide detailed certificates of analysis (CoA) and technical support. Given the peptide's sensitivity to degradation, proper storage conditions (e.g., lyophilized form at -20°C) are critical to maintaining its stability and efficacy.

In summary, Exendin(9-39) amide (CAS No. 133514-43-9) is a powerful research tool with wide-ranging applications in metabolic and neurological studies. Its ability to antagonize GLP-1R makes it indispensable for unraveling the complexities of glucose regulation and beyond. As research progresses, this peptide is likely to remain at the forefront of scientific discovery, offering new insights into some of the most pressing health challenges of our time.

• 106612-94-6(GLP-1(7-37))
• 29705-92-8(L-Arginine,L-phenylalanyl-L-seryl-L-tryptophylglycyl-L-alanyl-L-a-glutamylglycyl-L-glutaminyl-)
• 222018-18-0(L-Prolinamide,N-(1-oxooctadecyl)-L-tyrosylglycyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-L-arginyl-L-lysyl-L-tryptophyl-L-a-glutamyl-L-a-glutamyl-L-lysyl-L-isoleucyl-L-prolyl-L-asparaginyl-(9CI))
• 81123-06-0(Gastrin-1, rat)
• 9001-63-2(Lysozyme)
• 150238-87-2(Proadrenomedullin (1-20) (human))
• 16941-32-5(glucagon)
• 192387-38-5(Neuropeptide AF (human))
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)