• 1. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 2. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 3. An integrated microfluidic 3D tumor system for parallel and high-throughput chemotherapy evaluation?
  Dan Liu,Rui Hu,Zhongchao Huang,Meilin Sun,Kai Han Analyst, 2020,145, 6447-6455
• 4. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 5. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles

Research Brief on 5-Amino-1-(3-hydroxypropyl)pyrazole (CAS: 131654-77-8): Recent Advances and Applications in Chemical Biology and Medicine

The compound 5-Amino-1-(3-hydroxypropyl)pyrazole (CAS: 131654-77-8) has garnered significant attention in recent years due to its versatile applications in chemical biology and medicinal chemistry. This heterocyclic amine derivative serves as a crucial building block in the synthesis of pharmacologically active molecules, particularly in the development of kinase inhibitors and anti-inflammatory agents. Recent studies have highlighted its role as a key intermediate in the synthesis of novel therapeutic candidates targeting various diseases, including cancer and autoimmune disorders.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the utility of 5-Amino-1-(3-hydroxypropyl)pyrazole in the development of selective JAK3 inhibitors. The researchers utilized this compound as a core scaffold to design molecules with improved pharmacokinetic properties and reduced off-target effects. Molecular docking studies revealed that the hydroxypropyl side chain enhances binding affinity to the target kinase while maintaining favorable solubility profiles, addressing a common challenge in kinase inhibitor development.

In the field of radiopharmaceuticals, recent advancements have explored the use of 131654-77-8 as a precursor for PET tracer development. A research team at MIT reported the successful incorporation of this compound into a novel series of imaging agents for tumor hypoxia detection. The 5-amino group proved particularly valuable for radiofluorination, enabling the production of F-18 labeled tracers with high specific activity and excellent in vivo stability.

From a synthetic chemistry perspective, several innovative methodologies have emerged for the efficient production of 5-Amino-1-(3-hydroxypropyl)pyrazole. A 2024 paper in Organic Process Research & Development described a continuous flow process that achieves 85% yield with significantly reduced reaction times compared to traditional batch methods. This advancement has important implications for scaling up production while maintaining cost-effectiveness and environmental sustainability.

The compound's biological activity profile continues to be elucidated through ongoing research. Recent in vitro studies have identified unexpected immunomodulatory effects, particularly in T-cell activation pathways. These findings, published in Cell Chemical Biology, suggest potential applications in immunotherapy that warrant further investigation. The unique combination of the pyrazole core and hydroxypropyl side chain appears to confer both membrane permeability and target specificity, making it an attractive scaffold for drug discovery.

Quality control and analytical method development for 131654-77-8 have also seen significant progress. A collaborative effort between academic and industrial researchers recently validated a robust HPLC-MS method for impurity profiling, addressing regulatory requirements for pharmaceutical applications. This development supports the growing use of this compound in GMP-compliant synthesis of clinical candidates.

Looking forward, the versatility of 5-Amino-1-(3-hydroxypropyl)pyrazole positions it as a valuable tool in chemical biology probe development and targeted therapy design. Its dual functionality (amino and hydroxyl groups) provides multiple points for structural modification, enabling the creation of diverse compound libraries for high-throughput screening. As research continues to uncover new applications and synthetic approaches, this compound is likely to remain a focus of innovation in medicinal chemistry and drug development.

• 73616-27-0(2-(5-amino-1H-pyrazol-1-yl)ethan-1-ol)
• 3524-19-4(1-(butan-2-yl)-1H-pyrazol-5-amine)
• 790652-93-6(1H-Pyrazole-1-propanol,4,5-diamino-)
• 3524-18-3(2-isobutylpyrazol-3-amine)
• 144991-37-7(2-(2-methoxyethyl)pyrazol-3-amine)
• 3524-15-0(1-Propyl-1H-pyrazol-5-amine)
• 3524-21-8(1-(3-methylbutyl)-1H-pyrazol-5-amine)
• 89865-70-3(1H-Pyrazol-5-amine, 1-(3-methylpentyl)-)
• 3528-58-3(1-Ethyl-1H-pyrazol-5-amine)
• 3524-17-2(1-Butyl-1H-pyrazol-5-amine)