• 1. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 2. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 3. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 4. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles

Professional Introduction to 1-(butan-2-yl)-1H-pyrazol-5-amine (CAS No. 3524-19-4)

1-(butan-2-yl)-1H-pyrazol-5-amine, a compound with the chemical identifier CAS No. 3524-19-4, is a significant molecule in the field of pharmaceutical chemistry and medicinal research. This heterocyclic amine derivative has garnered considerable attention due to its unique structural properties and potential biological activities. The compound belongs to the pyrazole class, which is well-documented for its diverse pharmacological applications, ranging from anti-inflammatory to anticancer effects.

The molecular structure of 1-(butan-2-yl)-1H-pyrazol-5-amine consists of a pyrazole core substituted with a butyl group at the 1-position and an amine group at the 5-position. This specific arrangement contributes to its distinct chemical reactivity and interaction with biological targets. The butyl moiety enhances lipophilicity, while the amine group provides a site for hydrogen bonding and further functionalization, making it a versatile scaffold for drug design.

In recent years, there has been a surge in research focusing on developing novel therapeutic agents derived from pyrazole derivatives. The compound 1-(butan-2-yl)-1H-pyrazol-5-amine has been extensively studied for its potential in modulating various biological pathways. One of the most promising areas of investigation is its role in cancer therapy. Studies have shown that pyrazole-based compounds can inhibit key enzymes involved in tumor growth and progression, such as kinases and cyclases.

Moreover, the amine group in 1-(butan-2-yl)-1H-pyrazol-5-amine allows for further derivatization, enabling researchers to create analogs with enhanced pharmacological properties. For instance, modifications at the 3-position of the pyrazole ring have led to compounds with improved solubility and bioavailability. These advancements are crucial for developing next-generation drugs that can overcome the limitations of existing therapies.

The synthesis of 1-(butan-2-yl)-1H-pyrazol-5-amine involves multi-step organic reactions, typically starting from readily available precursors such as butanone and hydrazine hydrate. The introduction of the butyl group at the 1-position is achieved through nucleophilic substitution, while the amine functionality is introduced via condensation reactions. The synthesis route has been optimized to ensure high yield and purity, making it suitable for both laboratory-scale studies and industrial production.

Recent research has also highlighted the compound's potential in treating inflammatory diseases. Pyrazole derivatives are known to exhibit anti-inflammatory effects by inhibiting enzymes like COX (cyclooxygenase) and LOX (lipoxygenase), which are key players in inflammation pathways. The presence of the butyl group in 1-(butan-2-yl)-1H-pyrazol-5-amine appears to enhance its ability to interact with these enzymes, thereby modulating inflammatory responses.

In addition to its therapeutic applications, 1-(butan-2-yl)-1H-pyrazol-5-amine has shown promise in agricultural research. Pyrazole-based compounds can act as intermediates in the synthesis of pesticides and herbicides, offering new solutions for crop protection. The structural flexibility of this molecule allows for modifications that can target specific pests while minimizing environmental impact.

The pharmacokinetic properties of 1-(butan-2-yl)-1H-pyrazol-5-amine are also under investigation. Studies have indicated that the compound exhibits good oral bioavailability and moderate metabolic stability, suggesting its potential for clinical use. Further research is needed to fully understand its absorption, distribution, metabolism, and excretion (ADME) profiles, which are critical factors in drug development.

The future directions of research on CAS No. 3524-19-4, or more accurately referred to as 1-(butan-2-yi)-lH-pyraiole-l-amino , include exploring its interactions with novel targets and developing prodrugs that enhance its delivery and efficacy. Collaborative efforts between academic institutions and pharmaceutical companies are essential to translate these findings into tangible therapeutic benefits for patients worldwide.

• 3524-16-1(1-(propan-2-yl)-1H-pyrazol-5-amine)
• 3524-15-0(1-Propyl-1H-pyrazol-5-amine)
• 3524-21-8(1-(3-methylbutyl)-1H-pyrazol-5-amine)
• 3702-09-8(1-Cyclopentyl-1H-pyrazol-5-amine)
• 1015845-66-5(1-(1-Methylbutyl)-1H-pyrazol-5-amine)
• 442850-71-7(2-tert-butylpyrazol-3-amine)
• 3528-50-5(1-Cyclohexyl-1H-pyrazol-5-amine)
• 90206-24-9(1-(1-Ethylpropyl)-1H-pyrazol-5-amine)
• 3524-17-2(1-Butyl-1H-pyrazol-5-amine)
• 1015845-91-6(1-(1,2-Dimethylpropyl)-1H-pyrazol-5-amine)