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• Catalysts and Inorganic Chemicals Inorganic Compounds Mixed metal/non-metal compounds Alkali metal oxoanionic compounds Alkali metal phosphates
• Catalysts and Inorganic Chemicals Inorganic Compounds Salt

Sodium Ammonium Hydrophosphate (CAS No. 13011-54-6): A Comprehensive Overview

Sodium ammonium hydrogen phosphate (CAS No. 13011-54-6), chemically represented as NH?NaHPO?, is a versatile inorganic compound widely recognized for its multifunctional applications across chemical, pharmaceutical, and biotechnological domains. This crystalline salt, characterized by its ammonium and sodium cations paired with a hydrogen phosphate anion (HPO?2?), exhibits unique physicochemical properties that make it indispensable in diverse industrial and research settings. Recent advancements in materials science and drug delivery systems have further expanded its utility, positioning this compound at the forefront of innovative applications.

In pharmaceutical formulations, sodium ammonium hydrogen phosphate serves as a critical pH buffer system, stabilizing drug molecules during synthesis and storage. Its buffering capacity within the physiological range (pKa ≈ 7.2) aligns with biological environments, making it ideal for intravenous solutions and oral drug delivery platforms. A 2023 study published in the Journal of Pharmaceutical Sciences demonstrated its role in enhancing the solubility of poorly water-soluble drugs through co-crystallization techniques, thereby improving bioavailability without compromising chemical integrity.

Beyond traditional applications, this compound has emerged as a key component in nanostructured drug carriers. Researchers at MIT recently synthesized pH-sensitive liposomes using NH?NaHPO?-modified phospholipids, enabling targeted release of chemotherapeutic agents in tumor microenvironments. The compound's ability to modulate membrane permeability via proton-coupled ion exchange mechanisms was highlighted as a breakthrough for reducing off-target toxicity—a critical challenge in oncology.

In biotechnology, sodium ammonium hydrogen phosphate is integral to optimizing microbial growth media for recombinant protein production. A 2022 Nature Biotechnology paper revealed that incorporating this salt into fermentation broths increased yields of monoclonal antibodies by up to 35% through precise control of cellular osmotic pressure and ion homeostasis. The compound's dual cationic contributions (NH??/Na?) were shown to synergistically enhance protein folding efficiency during expression in Escherichia coli systems.

Recent advances in green chemistry have repurposed this compound as an eco-friendly catalyst for esterification reactions—a process critical for synthesizing prodrug intermediates. A collaborative study between ETH Zurich and Pfizer demonstrated that NH?NaHPO?-mediated solid-phase catalysis achieved >98% conversion rates under ambient conditions, eliminating the need for toxic organic solvents traditionally used in pharmaceutical synthesis. This innovation aligns with global sustainability initiatives while maintaining industrial scalability.

In analytical chemistry, sodium ammonium hydrogen phosphate finds application as a reference standard for calibrating ion chromatography systems due to its well-characterized ion composition and stability under high-pressure liquid chromatography (HPLC) conditions. Its certified purity (>99.9%) ensures accurate quantification of trace ions in environmental and clinical samples—a capability validated by ISO/IEC 17025-accredited laboratories worldwide.

Emerging research also explores its role in regenerative medicine scaffolds. A team from Stanford University engineered hydrogel matrices infused with NH?NaHPO? nanoparticles that mimic natural extracellular matrix mineralization processes. These biomaterials facilitated accelerated bone tissue regeneration in preclinical models by providing both structural support and bioactive signaling through controlled ion release—a development with significant implications for orthopedic therapies.

The compound's safety profile has been extensively validated through decades of clinical use. Regulatory databases such as the FDA's Inactive Ingredients Database list it as Generally Recognized As Safe (GRAS) when used within specified dosage limits. However, recent pharmacokinetic studies emphasize optimizing dosing protocols to account for inter-individual variations in renal clearance rates—a consideration particularly relevant for pediatric populations.

In conclusion, sodium ammonium hydrogen phosphate (CAS No. 13011-54-6) continues to evolve beyond conventional applications into cutting-edge biomedical technologies. Its unique combination of buffering capacity, catalytic potential, and biocompatibility positions it as an essential tool across multiple frontiers—from next-generation drug delivery systems to sustainable manufacturing processes—while ongoing research promises even broader horizons in personalized medicine and regenerative therapies.

• 25447-33-0(Triammonium phosphate trihydrate)
• 10039-32-4(Phosphoric acid disodium dodecahydrate)
• 51750-73-3(sodium ammonium hydrogen phosphate tetrahydrate)
• 68333-79-9(Ammonium Polyphosphate)
• 10028-24-7(Sodium Phosphate Dibasic Dihydrate)
• 10101-89-0(Trisodium phosphate dodecahydrate)
• 89140-32-9(sodium dihydrogen phosphate anhydrous)
• 15819-50-8(Trisodium phosphate hexahydrate)
• 7783-13-3(Ammonium Sodium Phosphate Tetrahydrate)
• 10049-21-5(Sodium phosphate monobasic monohydrate)