Production Method 1

1885-46-7

127842-55-1

83882-67-1

101975-23-9

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: 2-Methyltetrahydrofuran ,  Water ;  12 h, 23 °C
2.1 Solvents: 1,2-Dichloroethane ;  12 h, 60 °C
3.1 Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ;  12 h, 23 °C

Reference

Catalytic radical difluoromethoxylation of arenes and heteroarenes

Lee, Johnny W.; et al, Chemical Science, 2019, 10(11), 3217-3222

Production Method 2

2287306-92-5

98-86-2

37181-39-8

127842-55-1

83882-67-1

101975-23-9

Reaction Conditions

1.1 Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ;  12 h, 23 °C

Reference

Catalytic radical difluoromethoxylation of arenes and heteroarenes

Lee, Johnny W.; et al, Chemical Science, 2019, 10(11), 3217-3222

Production Method 3

98-86-2

37181-39-8

127842-55-1

83882-67-1

101975-23-9

Reaction Conditions

1.1 Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ;  30 min

Reference

Visible-Light Photoredox-Catalyzed C(sp2)-H Difluoromethoxylation of (Hetero)arenes Utilizing a Shelf-Stable Pyridinium Reagent

Lin, Daniel; et al, Organic Letters, 2022, 24(40), 7255-7259

Production Method 4

14906-59-3

1885-46-7

127842-55-1

83882-67-1

101975-23-9

Reaction Conditions

1.1 Solvents: Acetonitrile ;  18 h, 66 °C
2.1 Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ;  30 min

Reference

Visible-Light Photoredox-Catalyzed C(sp2)-H Difluoromethoxylation of (Hetero)arenes Utilizing a Shelf-Stable Pyridinium Reagent

Lin, Daniel; et al, Organic Letters, 2022, 24(40), 7255-7259

Production Method 5

2287306-91-4

333-27-7

127842-55-1

83882-67-1

101975-23-9

Reaction Conditions

1.1 Solvents: 1,2-Dichloroethane ;  12 h, 60 °C
2.1 Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ;  12 h, 23 °C

Reference

Catalytic radical difluoromethoxylation of arenes and heteroarenes

Lee, Johnny W.; et al, Chemical Science, 2019, 10(11), 3217-3222

Production Method 6

100-48-1

127842-55-1

83882-67-1

101975-23-9

Reaction Conditions

1.1 Reagents: Acetic acid ;  rt → 80 °C; reflux
1.2 Reagents: Hydrogen peroxide Solvents: Water ;  16 h
2.1 Solvents: Acetonitrile ;  18 h, 66 °C
3.1 Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ;  30 min

Reference

Visible-Light Photoredox-Catalyzed C(sp2)-H Difluoromethoxylation of (Hetero)arenes Utilizing a Shelf-Stable Pyridinium Reagent

Lin, Daniel; et al, Organic Letters, 2022, 24(40), 7255-7259

1-[2-(difluoromethoxy)phenyl]ethan-1-one Raw materials

• 1-(Difluoromethoxy)-6-nitro-4-(trifluoromethyl)-1H-benzotriazole
• 4-Cyanopyridine N-oxide
• 3-(Difluoromethoxy)-1-methyl-5-nitro-7-(trifluoromethyl)-1H-benzotriazolium
• 5-Methylpyrimidin-2-amine
• Methyl trifluoromethanesulfonate
• Acetophenone
• 4-Cyanopyridine

1-[2-(difluoromethoxy)phenyl]ethan-1-one Preparation Products

• 1-[4-(Difluoromethoxy)phenyl]ethan-1-one (83882-67-1)
• 3'-(Difluoromethoxy)acetophenone (101975-23-9)
• 1-[2-(difluoromethoxy)phenyl]ethan-1-one (127842-55-1)

• 1. An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives?
  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
• 2. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
• 3. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 4. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 5. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

• 145742-67-2(Benzaldehyde, 2-(difluoromethoxy)-5-ethyl-)
• 98566-94-0(Methanone,[2-(trifluoromethoxy)phenyl][4-(trifluoromethoxy)phenyl]-)
• 220227-93-0(2-(Trifluoromethoxy)acetophenone)
• 886500-08-9(2'-Methoxy-4'-(trifluoromethoxy)acetophenone)
• 141602-20-2(1-1-(difluoromethoxy)naphthalen-2-ylethan-1-one)
• 210816-49-2(1-2,4-Bis(difluoromethoxy)phenylethan-1-one)
• 405921-09-7(2-Bromo-1-(2-(difluoromethoxy)phenyl)ethanone)
• 468074-92-2(2'-Methoxy-5'-(trifluoromethoxy)acetophenone)
• 146575-64-6(2'-Hydroxy-5'-(Trifluoromethoxy)Acetophenone)
• 571158-90-2(1-2-(difluoromethoxy)-5-methylphenylethan-1-one)