• 1. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 2. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 3. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 4. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 5. Distinction of trans–cis photoisomers with comparable optical properties in multiple-state photochromic systems – examining a molecule with three azobenzenes via in situ irradiation NMR spectroscopy?
  Jonas Kind,Lukas Kaltschnee,Martin Leyendecker,Christina M. Thiele Chem. Commun., 2016,52, 12506-12509

Comprehensive Overview of (3-Methoxypyridin-2-yl)methanamine Dihydrochloride (CAS No. 1276056-71-3)

(3-Methoxypyridin-2-yl)methanamine dihydrochloride (CAS No. 1276056-71-3) is a specialized organic compound that has garnered significant attention in pharmaceutical and biochemical research. This compound, characterized by its pyridine backbone and methoxy functional group, serves as a versatile intermediate in the synthesis of bioactive molecules. Its unique structural features make it a valuable building block for drug discovery, particularly in the development of central nervous system (CNS) targeting agents and enzyme inhibitors.

The growing interest in (3-Methoxypyridin-2-yl)methanamine dihydrochloride aligns with current trends in precision medicine and small-molecule therapeutics. Researchers are increasingly exploring its potential applications in modulating neurotransmitter pathways, a hot topic in neurodegenerative disease research. The compound's amine functionality and aromatic system contribute to its ability to interact with biological targets, making it a subject of studies related to blood-brain barrier permeability and receptor binding affinity.

From a synthetic chemistry perspective, CAS 1276056-71-3 offers several advantages. Its dihydrochloride salt form enhances stability and solubility, addressing common challenges in compound formulation. This characteristic is particularly relevant to current discussions about drug bioavailability and oral administration optimization. The presence of both hydrogen bond donors and acceptors in its structure facilitates diverse molecular interactions, a feature highly sought after in fragment-based drug design approaches.

Analytical studies of (3-Methoxypyridin-2-yl)methanamine dihydrochloride typically employ advanced techniques such as HPLC, mass spectrometry, and NMR spectroscopy. These methods are crucial for verifying the compound's purity and structural integrity, especially given the pharmaceutical industry's emphasis on quality control and regulatory compliance. Recent publications have highlighted its utility in creating molecular probes for studying protein-ligand interactions, a rapidly growing area in chemical biology.

The compound's physicochemical properties have been extensively characterized, with particular focus on its pKa values, partition coefficient, and thermal stability. These parameters are essential for understanding its behavior in biological systems and during chemical synthesis. Current research trends suggest potential applications in developing allosteric modulators, a class of compounds receiving increasing attention in drug development circles due to their potential for enhanced selectivity.

In the context of green chemistry initiatives, synthetic routes to 1276056-71-3 have been optimized to reduce environmental impact. Modern approaches emphasize atom economy and the use of catalytic methods, reflecting broader industry shifts toward sustainable synthesis. These developments address common search queries about eco-friendly chemical production and green pharmaceutical intermediates.

Safety assessments of (3-Methoxypyridin-2-yl)methanamine dihydrochloride follow standard laboratory protocols, with particular attention to personal protective equipment requirements and waste disposal procedures. While not classified as hazardous under normal handling conditions, proper chemical hygiene practices are always recommended, a point frequently emphasized in laboratory safety guidelines and training materials.

The commercial availability of CAS 1276056-71-3 through specialized chemical suppliers has facilitated its adoption in various research programs. Current market trends show increasing demand for such pharmaceutical intermediates, driven by expansion in contract research organizations and academic drug discovery initiatives. This aligns with search patterns showing growing interest in research chemical sourcing and custom synthesis services.

Future research directions for (3-Methoxypyridin-2-yl)methanamine dihydrochloride may explore its potential in combinatorial chemistry libraries or as a scaffold for multitarget-directed ligands. These applications resonate with current interests in polypharmacology and network pharmacology approaches to complex diseases. The compound's structural flexibility positions it well for such innovative applications in medicinal chemistry.

In summary, (3-Methoxypyridin-2-yl)methanamine dihydrochloride represents an important tool in modern chemical research, with diverse applications spanning drug discovery, chemical biology, and material science. Its continued study contributes to advancing our understanding of structure-activity relationships and the development of novel therapeutic agents, addressing many current priorities in healthcare innovation and scientific research.

• 828242-02-0(2-(aminomethyl)-6-methylpyridin-3-ol)
• 595560-87-5((3-Methoxypyridin-2-yl)methanamine)
• 1256785-61-1(3,5-diethoxy-2-Pyridinemethanamine)
• 194665-89-9(2-(Aminomethyl)pyridin-3-ol)
• 574705-02-5(2-(aminomethyl)pyridin-3-ol hydrochloride)
• 1307300-53-3((3-methoxypyridin-2-yl)methyl(methyl)amine)
• 1112851-41-8(6-ethyl-5-methoxy-2-Pyridinemethanamine hydrochloride)
• 1256816-67-7((3,5-dimethoxypyridin-2-yl)methanamine)
• 1588441-00-2((3-Methoxypyridin-2-yl)methanamine hydrochloride)
• 905306-69-6((5-Methoxypyridin-2-yl)methanamine)