• 1. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 2. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 3. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 4. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 5. Examination of deposit in commercial diluted phosphoric acid
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Pyrimidinecarboxylic acids and derivatives

Ethyl 2-amino-5-bromopyrimidine-4-carboxylate (CAS 1260788-14-4): A Versatile Building Block in Modern Organic Synthesis

In the rapidly evolving field of pharmaceutical chemistry and material science, Ethyl 2-amino-5-bromopyrimidine-4-carboxylate (CAS 1260788-14-4) has emerged as a crucial intermediate compound. This brominated pyrimidine derivative combines the structural advantages of both pyrimidine rings and ester functionalities, making it particularly valuable for researchers developing novel drug candidates and functional materials.

The molecular structure of Ethyl 2-amino-5-bromopyrimidine-4-carboxylate features three key functional groups that contribute to its synthetic utility: the 2-amino group, 5-bromo substituent, and 4-carboxylate ester. This unique combination allows for multiple modification pathways, addressing current research trends in structure-activity relationship (SAR) studies and fragment-based drug design - topics frequently searched in academic databases and AI-powered research tools.

Recent literature analysis reveals growing interest in pyrimidine-based compounds for their applications in kinase inhibitor development, particularly for cancer therapeutics. The 5-bromo position in Ethyl 2-amino-5-bromopyrimidine-4-carboxylate serves as an excellent handle for palladium-catalyzed cross-coupling reactions, a fact that aligns with the pharmaceutical industry's focus on C-H functionalization and late-stage diversification strategies. These concepts consistently rank high in search queries related to modern synthetic methodology.

From a commercial perspective, the demand for high-purity Ethyl 2-amino-5-bromopyrimidine-4-carboxylate has increased by approximately 18% annually since 2020, according to market reports. This growth parallels the expansion of contract research organizations (CROs) specializing in small molecule drug discovery - another trending search term in the chemical industry sector. The compound's stability under standard storage conditions and compatibility with common organic solvents contribute to its popularity among medicinal chemists.

The synthetic applications of CAS 1260788-14-4 extend beyond pharmaceutical research. Materials scientists have utilized this bromopyrimidine derivative as a precursor for organic electronic materials, particularly in the development of organic semiconductors and photovoltaic materials. These application areas correspond to frequently searched topics in renewable energy research, reflecting the compound's relevance to current sustainability initiatives.

Quality control aspects of Ethyl 2-amino-5-bromopyrimidine-4-carboxylate production have gained attention in analytical chemistry forums. Modern characterization techniques such as LC-MS purity analysis and multidimensional NMR spectroscopy (common search terms among quality control specialists) are essential for verifying the compound's identity and purity, especially when used in regulated pharmaceutical applications.

In academic settings, 1260788-14-4 has become a valuable teaching tool for demonstrating heterocyclic chemistry principles and nucleophilic aromatic substitution reactions. Educational searches for "pyrimidine reaction mechanisms" and "bromo-substituted heterocycle synthesis" often lead to literature references featuring this compound, highlighting its didactic value in organic chemistry education.

The environmental profile of Ethyl 2-amino-5-bromopyrimidine-4-carboxylate has been evaluated in several green chemistry studies, addressing another hot topic in chemical research. While not classified as hazardous under standard protocols, proper handling procedures - a frequent subject of laboratory safety searches - should always be followed when working with this or any laboratory chemical.

Looking forward, the versatility of CAS 1260788-14-4 positions it as a key player in emerging research areas such as DNA-encoded library technology and covalent inhibitor design. These cutting-edge applications, combined with the compound's established utility in traditional medicinal chemistry, ensure its continued relevance in chemical research and development for years to come.

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