Cas no 1256955-32-4 (6-BROMO-4,7-DICHLOROQUINAZOLINE)

6-Bromo-4,7-dichloroquinazoline is a halogenated quinazoline derivative widely utilized as a versatile intermediate in organic synthesis and pharmaceutical research. Its distinct bromo and chloro substituents at the 6, 4, and 7 positions enable selective functionalization, making it valuable for constructing complex heterocyclic frameworks. The compound exhibits high reactivity in nucleophilic aromatic substitution (SNAr) and cross-coupling reactions, facilitating the development of biologically active molecules, including kinase inhibitors and other therapeutic agents. Its stability under standard handling conditions and well-characterized reactivity profile ensure consistent performance in synthetic applications. This compound is particularly useful in medicinal chemistry for structure-activity relationship (SAR) studies and targeted drug design.
6-BROMO-4,7-DICHLOROQUINAZOLINE structure
1256955-32-4 structure
Product Name:6-BROMO-4,7-DICHLOROQUINAZOLINE
CAS No:1256955-32-4
MF:C8H3BrCl2N2
MW:277.93
MDL:MFCD22627878
CID:2145498
PubChem ID:87167311
Update Time:2025-06-14

6-BROMO-4,7-DICHLOROQUINAZOLINE Chemical and Physical Properties

Names and Identifiers

    • 6-bromo-4,7-dichloroquinazoline
    • FKUZYQQFPBBHKU-UHFFFAOYSA-N
    • CID 87167311
    • Quinazoline, 6-bromo-4,7-dichloro-
    • MFCD22627878
    • EN300-6237944
    • PB40114
    • CS-0132550
    • PS-16676
    • 1256955-32-4
    • SCHEMBL855424
    • DB-369143
    • SY321981
    • 6-BROMO-4,7-DICHLOROQUINAZOLINE
    • MDL: MFCD22627878
    • Inchi: 1S/C8H3BrCl2N2/c9-5-1-4-7(2-6(5)10)12-3-13-8(4)11/h1-3H
    • InChI Key: FKUZYQQFPBBHKU-UHFFFAOYSA-N
    • SMILES: BrC1C(=CC2C(=C(N=CN=2)Cl)C=1)Cl

Computed Properties

  • Exact Mass: 275.88567g/mol
  • Monoisotopic Mass: 275.88567g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 13
  • Rotatable Bond Count: 0
  • Complexity: 193
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 25.8
  • XLogP3: 3.8

Experimental Properties

  • Density: 1.851±0.06 g/cm3(Predicted)
  • Boiling Point: 378.4±37.0 °C(Predicted)
  • pka: 0.11±0.70(Predicted)

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Additional information on 6-BROMO-4,7-DICHLOROQUINAZOLINE

Comprehensive Overview of 6-BROMO-4,7-DICHLOROQUINAZOLINE (CAS No. 1256955-32-4)

6-BROMO-4,7-DICHLOROQUINAZOLINE (CAS No. 1256955-32-4) is a halogenated quinazoline derivative that has garnered significant attention in pharmaceutical and agrochemical research due to its versatile chemical properties. This compound belongs to the quinazoline family, a class of heterocyclic compounds known for their broad biological activities. Researchers and industry professionals frequently search for 6-BROMO-4,7-DICHLOROQUINAZOLINE synthesis, applications in drug discovery, and its role in kinase inhibition, making it a topic of high relevance in modern chemistry.

The molecular structure of 6-BROMO-4,7-DICHLOROQUINAZOLINE features a quinazoline core substituted with bromine and chlorine atoms at positions 6, 4, and 7, respectively. These halogen substitutions enhance its reactivity and make it a valuable intermediate in organic synthesis. Recent studies highlight its potential in designing targeted therapies for cancer and inflammatory diseases, aligning with the growing demand for precision medicine. Searches for halogenated quinazoline derivatives and quinazoline-based inhibitors have surged, reflecting the compound's importance in medicinal chemistry.

In addition to its pharmaceutical applications, 6-BROMO-4,7-DICHLOROQUINAZOLINE is explored in material science for developing organic electronic materials. Its electron-deficient nature makes it suitable for constructing charge-transfer complexes and semiconductors. This dual utility in life sciences and materials engineering underscores its interdisciplinary appeal. Users often inquire about quinazoline derivatives in optoelectronics or CAS No. 1256955-32-4 suppliers, indicating a diverse interest spectrum.

The synthesis of 6-BROMO-4,7-DICHLOROQUINAZOLINE typically involves multi-step reactions, including halogenation and cyclization processes. Optimizing these methods to improve yield and purity is a key focus area, as evidenced by searches for efficient quinazoline synthesis protocols. Environmental considerations also drive interest in green chemistry approaches for producing such intermediates, aligning with global sustainability trends.

Analytical characterization of 6-BROMO-4,7-DICHLOROQUINAZOLINE employs techniques like NMR, HPLC, and mass spectrometry. Researchers frequently seek spectral data for CAS No. 1256955-32-4 to validate compound identity, highlighting the need for accessible reference materials. The compound's stability under various conditions is another hot topic, with queries about storage recommendations for halogenated quinazolines.

As the demand for novel bioactive compounds rises, 6-BROMO-4,7-DICHLOROQUINAZOLINE continues to attract attention for its structural modularity. Its role in fragment-based drug design and combinatorial chemistry is particularly noteworthy. Online discussions often center on quinazoline scaffold modifications and structure-activity relationship studies, demonstrating its centrality in modern drug development pipelines.

In conclusion, 6-BROMO-4,7-DICHLOROQUINAZOLINE (CAS No. 1256955-32-4) represents a multifaceted chemical entity with expanding applications across scientific disciplines. Its prominence in literature and search trends reflects the ongoing exploration of quinazoline chemistry to address contemporary challenges in healthcare and technology.

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