• 1. An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme?
  Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023
• 2. An investigation on the interaction modes of a single-strand DNA aptamer and RBP4 protein: a molecular dynamic simulations approach?
  Raheleh Torabi,Hedayatollah Ghourchian,Massoud Amanlou Org. Biomol. Chem., 2016,14, 8141-8153
• 3. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 4. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535
• 5. An automated computational approach to kinetic model discrimination and parameter estimation?
  Connor J. Taylor,Hikaru Seki,Friederike M. Dannheim,Mark J. Willis,Graeme Clemens,Brian A. Taylor,Thomas W. Chamberlain,Richard A. Bourne React. Chem. Eng., 2021,6, 1404-1411

8-Bromo-4-chloroquinazoline: A Comprehensive Overview

The compound with CAS No. 125096-72-2, commonly referred to as 8-Bromo-4-chloroquinazoline, is a heterocyclic aromatic compound that has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science. This compound belongs to the quinazoline family, which is a class of nitrogen-containing bicyclic aromatic compounds. The presence of bromine and chlorine substituents at the 8th and 4th positions, respectively, imparts unique chemical and physical properties to 8-Bromo-4-chloroquinazoline, making it a valuable molecule for various applications.

Recent studies have highlighted the potential of 8-Bromo-4-chloroquinazoline as a promising candidate in drug discovery. Researchers have explored its role as a kinase inhibitor, particularly targeting enzymes involved in cell signaling pathways. For instance, a study published in the *Journal of Medicinal Chemistry* demonstrated that 8-Bromo-4-chloroquinazoline exhibits potent inhibitory activity against protein kinase C (PKC), a key enzyme in cancer cell proliferation. This finding underscores its potential as an anticancer agent.

In addition to its pharmacological applications, 8-Bromo-4-chloroquinazoline has also been investigated for its electronic properties. The compound's ability to act as a semiconductor material has been explored in the context of organic electronics. A research team from the University of Cambridge reported that thin films of 8-Bromo-4-chloroquinazoline exhibit favorable charge transport characteristics, making them suitable for use in organic field-effect transistors (OFETs). This discovery opens new avenues for its application in flexible electronics and optoelectronic devices.

The synthesis of 8-Bromo-4-chloroquinazoline involves a multi-step process that typically begins with the preparation of quinazoline derivatives. One common method involves the condensation of o-phenylenediamine with an aldehyde or ketone derivative, followed by bromination and chlorination steps to introduce the respective substituents. Recent advancements in catalytic methods have enabled more efficient and selective synthesis pathways, reducing production costs and improving yields.

From an environmental perspective, the stability and biodegradability of 8-Bromo-4-chloroquinazoline are critical considerations. Studies conducted by environmental scientists have shown that the compound exhibits moderate persistence in aquatic environments, with degradation rates influenced by factors such as pH and temperature. These findings are essential for assessing its ecological impact and ensuring safe handling practices in industrial settings.

In conclusion, 8-Bromo-4-chloroquinazoline (CAS No. 125096-72-2) is a versatile compound with diverse applications across multiple scientific disciplines. Its unique chemical structure, combined with recent breakthroughs in synthesis and application development, positions it as a valuable tool in modern research and industry. As ongoing studies continue to uncover new properties and uses, the significance of this compound is expected to grow further.

• 573675-55-5(7-Bromo-4-chloroquinazoline)
• 102393-82-8(6-Bromo-2,4-dichloroquinazoline)
• 331647-05-3(8-Bromo-2,4-dichloroquinazoline)
• 351426-04-5(6-Bromo-4-chloro-2-methylquinazoline)
• 1100207-81-5(8-Bromo-4-chloro-6-methylquinazoline)
• 959237-68-4(7-bromo-2,4-dichloro-quinazoline)
• 38267-96-8(6-Bromo-4-chloroquinazoline)
• 885524-31-2(QUINAZOLINE, 6,7-DIBROMO-4-CHLORO-)
• 403850-84-0(7-Bromo-4-chloro-2-methylquinazoline)
• 2148-38-1(5-Bromo-4-chloro-quinazoline)