Cas no 123184-17-8 (1-(2,4-difluorophenyl)prop-2-en-1-one)

1-(2,4-Difluorophenyl)prop-2-en-1-one is a fluorinated aromatic enone compound characterized by its reactive α,β-unsaturated ketone functionality. The presence of electron-withdrawing fluorine substituents at the 2- and 4-positions of the phenyl ring enhances its electrophilic reactivity, making it a valuable intermediate in organic synthesis, particularly for Michael additions and cyclization reactions. Its structural features contribute to improved stability and selectivity in cross-coupling and heterocycle formation. The compound is commonly utilized in pharmaceutical and agrochemical research for the development of fluorinated bioactive molecules. High purity grades are available to ensure consistent performance in demanding synthetic applications.
1-(2,4-difluorophenyl)prop-2-en-1-one structure
123184-17-8 structure
Product Name:1-(2,4-difluorophenyl)prop-2-en-1-one
CAS No:123184-17-8
MF:C9H6F2O
MW:168.140149593353
CID:6256477
PubChem ID:57752306
Update Time:2025-05-22

1-(2,4-difluorophenyl)prop-2-en-1-one Chemical and Physical Properties

Names and Identifiers

    • 1-(2,4-difluorophenyl)prop-2-en-1-one
    • AKOS014911995
    • EN300-1230721
    • 123184-17-8
    • Inchi: 1S/C9H6F2O/c1-2-9(12)7-4-3-6(10)5-8(7)11/h2-5H,1H2
    • InChI Key: PRSPFQORFUZLMD-UHFFFAOYSA-N
    • SMILES: FC1C=C(C=CC=1C(C=C)=O)F

Computed Properties

  • Exact Mass: 168.03867113g/mol
  • Monoisotopic Mass: 168.03867113g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 2
  • Complexity: 191
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.4
  • Topological Polar Surface Area: 17.1?2

1-(2,4-difluorophenyl)prop-2-en-1-one Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Enamine
EN300-1230721-0.05g
1-(2,4-difluorophenyl)prop-2-en-1-one
123184-17-8
0.05g
$924.0 2023-06-08
Enamine
EN300-1230721-0.1g
1-(2,4-difluorophenyl)prop-2-en-1-one
123184-17-8
0.1g
$968.0 2023-06-08
Enamine
EN300-1230721-0.25g
1-(2,4-difluorophenyl)prop-2-en-1-one
123184-17-8
0.25g
$1012.0 2023-06-08
Enamine
EN300-1230721-0.5g
1-(2,4-difluorophenyl)prop-2-en-1-one
123184-17-8
0.5g
$1056.0 2023-06-08
Enamine
EN300-1230721-1.0g
1-(2,4-difluorophenyl)prop-2-en-1-one
123184-17-8
1g
$1100.0 2023-06-08
Enamine
EN300-1230721-2.5g
1-(2,4-difluorophenyl)prop-2-en-1-one
123184-17-8
2.5g
$2155.0 2023-06-08
Enamine
EN300-1230721-5.0g
1-(2,4-difluorophenyl)prop-2-en-1-one
123184-17-8
5g
$3189.0 2023-06-08
Enamine
EN300-1230721-10.0g
1-(2,4-difluorophenyl)prop-2-en-1-one
123184-17-8
10g
$4729.0 2023-06-08
Enamine
EN300-1230721-50mg
1-(2,4-difluorophenyl)prop-2-en-1-one
123184-17-8
50mg
$528.0 2023-10-02
Enamine
EN300-1230721-100mg
1-(2,4-difluorophenyl)prop-2-en-1-one
123184-17-8
100mg
$553.0 2023-10-02

1-(2,4-difluorophenyl)prop-2-en-1-one Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Potassium hydroxide Catalysts: Iridium(1+), chloro[2-(4,5-dihydro-1H-imidazol-2-yl-κN3)-5-methoxypyridine-κN][(… Solvents: Water ;  10 h, 80 °C
Reference
Iridium Complexes as Efficient Catalysts for Construction of α-Substituted Ketones via Hydrogen Borrowing of Alcohols in Water
Luo, Nianhua; Zhong, Yuhong; Wen, Huiling; Shui, Hongling; Luo, Renshi, European Journal of Organic Chemistry, 2021, 2021(9), 1355-1364

1-(2,4-difluorophenyl)prop-2-en-1-one Raw materials

1-(2,4-difluorophenyl)prop-2-en-1-one Preparation Products

Additional information on 1-(2,4-difluorophenyl)prop-2-en-1-one

Introduction to 1-(2,4-Difluorophenyl)Prop-2-En-1-One (CAS No. 123184-17-8)

1-(2,4-Difluorophenyl)prop-2-en-1-one, commonly referred to by its CAS number CAS No. 123184-17-8, is a versatile organic compound with significant applications in various fields of chemistry and material science. This compound is characterized by its unique structure, which includes a fluorinated aromatic ring and a ketone group. The presence of the fluorine atoms at the 2 and 4 positions of the phenyl ring imparts distinct electronic and steric properties to the molecule, making it highly valuable in synthetic chemistry and drug design.

Recent studies have highlighted the potential of CAS No. 123184-17-8 as a building block in the synthesis of bioactive compounds. Its ability to undergo various transformations, such as nucleophilic additions and cycloadditions, has made it a key intermediate in the development of novel pharmaceutical agents. For instance, researchers have utilized this compound to synthesize derivatives with anti-inflammatory and anticancer properties.

The synthesis of CAS No. 123184-17-8 typically involves multi-step processes that require precise control over reaction conditions. One common approach is the Friedel-Crafts acylation reaction, where an acyl chloride reacts with a fluorinated aromatic ring in the presence of a Lewis acid catalyst. This method ensures high yields and excellent regioselectivity, which are critical for maintaining the integrity of the fluorine substituents.

In terms of physical properties, CAS No. 123184-17-8 exhibits a melting point of approximately 65°C and a boiling point around 95°C under standard pressure. Its solubility in common organic solvents such as dichloromethane and ethyl acetate makes it suitable for use in various organic reactions. The compound is also relatively stable under normal storage conditions, provided it is protected from light and moisture.

The application of CAS No. 123184-17-8 extends beyond pharmaceuticals into materials science. Recent advancements have demonstrated its utility in the preparation of advanced polymers and coatings with enhanced thermal stability and mechanical properties. By incorporating this compound into polymer matrices, researchers have achieved significant improvements in material durability under harsh environmental conditions.

Moreover, CAS No. 123184-17-8 has found applications in agrochemicals, particularly in the development of herbicides and fungicides. Its ability to inhibit specific enzymes involved in plant growth pathways has made it a promising candidate for sustainable agricultural practices.

In conclusion, CAS No. 123184-17-8, or CAS No: CAS No: CAS Number: CAS Registry Number: , stands out as a multifaceted compound with wide-ranging applications across various industries. Its unique chemical structure, coupled with its reactivity and stability, positions it as an essential tool in modern synthetic chemistry.

Recommended suppliers
Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd.
Jiangxi Boyang Pharmaceutical Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Jiangxi Boyang Pharmaceutical Chemical Co., Ltd
PRIBOLAB PTE.LTD
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
PRIBOLAB PTE.LTD
Shandong Jing Kun Chemical Co.,Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Shandong Jing Kun Chemical Co.,Ltd.
Shanghai Jinhuan Chemical CO., LTD.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Shanghai Jinhuan Chemical CO., LTD.