• 1. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
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• 2. An aptamer-based keypad lock system?
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• 3. An integrated microfluidic 3D tumor system for parallel and high-throughput chemotherapy evaluation?
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• 4. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
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• 5. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
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4,5-Dichloro-1H-Indole: Properties, Applications, and Market Insights

4,5-Dichloro-1H-indole (CAS No. 122509-73-3) is a halogenated indole derivative that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its dichloro-substituted indole structure, serves as a versatile intermediate in organic synthesis. Its unique chemical properties make it valuable for developing bioactive molecules, particularly in drug discovery and crop protection.

The molecular formula of 4,5-dichloro-1H-indole is C₈H₅Cl₂N, with a molecular weight of 186.04 g/mol. The presence of chlorine atoms at the 4 and 5 positions of the indole ring enhances its reactivity, enabling diverse chemical transformations. Researchers often explore its potential in synthesizing heterocyclic compounds, which are crucial in medicinal chemistry. Recent studies highlight its role in creating novel antimicrobial agents and anti-inflammatory compounds, addressing global health challenges.

In the pharmaceutical industry, 4,5-dichloro-1H-indole is a key building block for developing small-molecule drugs. Its structural motif is found in several drug candidates targeting central nervous system (CNS) disorders and metabolic diseases. For instance, derivatives of this compound have shown promise in modulating G-protein-coupled receptors (GPCRs), a hot topic in drug development. The compound's ability to interact with biological targets makes it a focal point for high-throughput screening programs.

Beyond pharmaceuticals, 4,5-dichloro-1H-indole finds applications in agrochemical research. Its derivatives are investigated for their potential as pesticides and herbicides, contributing to sustainable agriculture. The compound's halogenated structure imparts stability and bioactivity, making it suitable for designing crop protection agents. With the growing demand for eco-friendly agrochemicals, this compound aligns with trends toward green chemistry and reduced environmental impact.

The synthesis of 4,5-dichloro-1H-indole typically involves electrophilic aromatic substitution reactions, with careful control of reaction conditions to ensure high yield and purity. Advanced techniques like microwave-assisted synthesis and catalyzed cross-coupling have been employed to optimize its production. Researchers also explore biocatalytic methods to enhance sustainability, reflecting the industry's shift toward green synthesis.

Market demand for 4,5-dichloro-1H-indole is driven by its applications in drug discovery and agrochemical innovation. The compound is available through specialized chemical suppliers, often with custom synthesis options. Pricing varies based on purity and scale, with bulk quantities preferred for industrial applications. Regulatory compliance, such as REACH and GMP standards, ensures its safe handling and use in research and production.

Recent advancements in computational chemistry have further highlighted the potential of 4,5-dichloro-1H-indole. Molecular docking studies and quantum mechanical calculations predict its interactions with biological targets, accelerating drug design. These innovations align with the rise of AI-driven drug discovery, a trending topic in the scientific community.

In summary, 4,5-dichloro-1H-indole (CAS No. 122509-73-3) is a multifaceted compound with significant implications for pharmaceuticals and agrochemicals. Its dichloro-substituted indole structure, combined with evolving synthetic methods, positions it as a valuable tool for researchers. As the industry prioritizes sustainable chemistry and targeted therapeutics, this compound will likely remain a focus of innovation.

• 40635-11-8(6,7-Dichloroquinoline)
• 121859-57-2(5,6-Dichloro-1H-indole)
• 136669-25-5(1H-Indole, 4-chloro-,conjugate acid (1:1))
• 101495-18-5(4,6-Dichloro-1H-indole)
• 1019-14-3(Acridine, 2,9-dichloro-)
• 86-98-6(4,7-Dichloroquinoline)
• 17422-33-2(6-Chloroindole)
• 25235-85-2(4-Chloroindole)
• 611-35-8(4-Chloroquinoline)
• 635-27-8(5-Chloroquinoline)