• 1. Dynamic treatment of chemisorbed species by means of infra-red technique. Mechanism of decomposition of formic acid over alumina and silica
  Yuko Noto,Kenzo Fukuda,Takaharu Onishi,Kenzi Tamaru Trans. Faraday Soc. 1967 63 2300

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Acridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Benzoquinolines Acridines

Acridine, 2,9-dichloro- (CAS No. 1019-14-3): A Comprehensive Overview

Acridine, 2,9-dichloro- (CAS No. 1019-14-3) is a significant compound in the field of chemical biology and pharmaceutical research. This heterocyclic organic molecule, characterized by its chlorinated acridine structure, has garnered considerable attention due to its versatile applications in various scientific domains. The compound's unique chemical properties make it a valuable tool in the synthesis of complex molecules and the development of innovative therapeutic agents.

The CAS No. 1019-14-3 identifier is a critical reference point for researchers and chemists, ensuring precise identification and differentiation from other related compounds. The presence of two chlorine atoms at the 2 and 9 positions of the acridine ring enhances its reactivity and functionality, making it a preferred intermediate in organic synthesis. This structural feature allows for further modifications, enabling the creation of a wide array of derivatives with tailored properties.

In recent years, the study of acridine derivatives has seen remarkable advancements, particularly in the realm of medicinal chemistry. The 2,9-dichloroacridine core has been extensively explored for its potential in developing novel anticancer agents. Researchers have leveraged its ability to interact with DNA and disrupt cancer cell proliferation. Several studies have demonstrated its efficacy in inhibiting specific enzymes and pathways involved in tumor growth, highlighting its promise as a lead compound in oncology research.

One of the most compelling aspects of Acridine, 2,9-dichloro- is its role in the development of fluorescent probes for biological imaging. The compound's ability to emit light upon excitation makes it an excellent candidate for use in fluorescence microscopy and other imaging techniques. These probes have been instrumental in studying cellular processes at a molecular level, providing insights into mechanisms that are otherwise difficult to observe. The chlorinated acridine structure enhances its photophysical properties, making it more suitable for such applications.

The pharmaceutical industry has also been keenly interested in Acridine, 2,9-dichloro-, particularly for its potential as a kinase inhibitor. Kinases are enzymes that play a crucial role in many cellular processes, including signal transduction and cell division. By inhibiting specific kinases, Acridine derivatives can disrupt these processes, offering a therapeutic approach to various diseases. Preliminary clinical trials have shown promising results in treating certain types of cancer by targeting key kinases involved in tumor progression.

Furthermore, the compound's chemical stability under various conditions makes it an attractive candidate for industrial applications. Its robustness ensures consistent performance in synthetic reactions, which is essential for large-scale production processes. This stability is particularly important in pharmaceutical manufacturing, where reproducibility and reliability are paramount.

The synthesis of Acridine, 2,9-dichloro-, while not overly complex, requires careful optimization to achieve high yields and purity. Researchers have developed several synthetic routes that leverage different reagents and conditions to produce this compound efficiently. These methods often involve multi-step reactions that require precise control over reaction parameters such as temperature, pressure, and pH.

Environmental considerations also play a significant role in the production and handling of Acridine derivatives. Efforts have been made to develop greener synthetic routes that minimize waste and reduce energy consumption. These sustainable practices are essential for ensuring that the production of this valuable compound does not come at an environmental cost.

In conclusion, Acridine, 2,9-dichloro- (CAS No. 1019-14-3) is a multifaceted compound with broad applications in chemical biology and pharmaceutical research. Its unique structural features make it an invaluable tool for developing innovative therapeutic agents and diagnostic probes. As research continues to uncover new applications for this compound, its significance is likely to grow even further.

• 366495-92-3(4,7-Dichloroquinoline-15N)
• 4203-18-3(4,6-Dichloroquinoline)
• 12365-92-3(4,7-Dichloroquinolinium tribromide)
• 86-98-6(4,7-Dichloroquinoline)
• 62383-19-1(Acridine, 2,6,9-trichloro-)
• 35547-70-7(6,9-Dichloroacridine)
• 1138471-54-1(4,7-DichloroQuinoline)
• 1207-69-8(9-Chloroacridine)
• 611-35-8(4-Chloroquinoline)
• 635-27-8(5-Chloroquinoline)