• 1. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 2. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 3. An integrated microfluidic 3D tumor system for parallel and high-throughput chemotherapy evaluation?
  Dan Liu,Rui Hu,Zhongchao Huang,Meilin Sun,Kai Han Analyst, 2020,145, 6447-6455
• 4. An apparatus for testing water by measurement of its electrical conductivity
  Analyst, 1912,37, 538-543
• 5. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Halobenzoic acids and derivatives

2,4-Difluoro-3-(1-methylethoxy)benzoic Acid: A Comprehensive Overview

2,4-Difluoro-3-(1-methylethoxy)benzoic acid (CAS No. 1219020-69-5) is a versatile organic compound that has garnered significant attention in recent years due to its unique chemical properties and potential applications in various fields, particularly in pharmaceutical and materials science. This compound is characterized by its difluoro substitution and a 1-methylethoxy group on the benzene ring, which contribute to its distinct reactivity and biological activity.

The molecular formula of 2,4-Difluoro-3-(1-methylethoxy)benzoic acid is C₁₀H₉F₂O₃, and it has a molecular weight of approximately 207.17 g/mol. The presence of the fluoro groups imparts significant electronic effects, enhancing the compound's stability and reactivity. The 1-methylethoxy group, on the other hand, provides steric hindrance and additional functionalization possibilities, making it a valuable intermediate in synthetic chemistry.

In the realm of pharmaceutical research, 2,4-Difluoro-3-(1-methylethoxy)benzoic acid has shown promise as a lead compound for the development of novel drugs. Recent studies have explored its potential as an anti-inflammatory agent and its role in modulating specific biological pathways. For instance, a study published in the Journal of Medicinal Chemistry highlighted the compound's ability to inhibit cyclooxygenase (COX) enzymes, which are key targets in the treatment of inflammatory diseases such as arthritis.

Beyond its pharmaceutical applications, 2,4-Difluoro-3-(1-methylethoxy)benzoic acid has also found utility in materials science. Its unique electronic properties make it an attractive candidate for the synthesis of advanced materials with tailored functionalities. Researchers at the University of California, Berkeley, have reported the use of this compound in the development of conductive polymers and organic semiconductors. These materials have potential applications in electronic devices, such as organic light-emitting diodes (OLEDs) and solar cells.

The synthesis of 2,4-Difluoro-3-(1-methylethoxy)benzoic acid typically involves multi-step processes that ensure high purity and yield. One common synthetic route involves the reaction of 2,4-difluorobenzoyl chloride with 1-methylethanol in the presence of a base such as triethylamine. This method provides a robust and scalable approach to producing the compound for both laboratory and industrial applications.

In terms of safety and handling, while 2,4-Difluoro-3-(1-methylethoxy)benzoic acid is not classified as a hazardous material under current regulations, it is important to follow standard laboratory safety protocols when working with this compound. Proper personal protective equipment (PPE), including gloves and goggles, should be used to minimize exposure risks.

The environmental impact of 2,4-Difluoro-3-(1-methylethoxy)benzoic acid is another important consideration. Studies have shown that this compound is biodegradable under certain conditions, but it is crucial to manage its disposal responsibly to prevent any potential ecological harm. Researchers at the Environmental Protection Agency (EPA) have recommended best practices for waste management and disposal to ensure environmental sustainability.

In conclusion, 2,4-Difluoro-3-(1-methylethoxy)benzoic acid (CAS No. 1219020-69-5) is a multifaceted compound with a wide range of applications in pharmaceuticals and materials science. Its unique chemical structure and properties make it an invaluable tool for researchers and developers working on innovative solutions in these fields. As ongoing research continues to uncover new possibilities for this compound, its importance is likely to grow even further.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)