• 1. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 2. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 3. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 4. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 5. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565

4-Bromo-2-(methylsulphonyl)benzonitrile: A Comprehensive Overview

4-Bromo-2-(methylsulphonyl)benzonitrile, also known by its CAS number 1208402-11-2, is a highly specialized organic compound that has garnered significant attention in the fields of pharmaceutical chemistry and materials science. This compound is characterized by its unique structure, which combines a bromine atom at the para position, a methylsulfonyl group at the meta position, and a cyano group at the ortho position of a benzene ring. The combination of these functional groups imparts distinctive chemical properties, making it a valuable molecule for various applications.

The synthesis of 4-Bromo-2-(methylsulphonyl)benzonitrile involves a multi-step process that typically begins with the bromination of an aromatic compound. The introduction of the methylsulfonyl group is achieved through sulfonation reactions, while the cyano group is introduced via nucleophilic substitution or other specialized techniques. Recent advancements in catalytic methods have enabled more efficient and environmentally friendly syntheses, reducing production costs and minimizing waste.

One of the most promising applications of this compound lies in its potential as a building block for drug development. The bromine atom serves as an excellent leaving group, facilitating further substitution reactions to create bioactive molecules. For instance, researchers have explored its use in constructing heterocyclic compounds that exhibit anti-cancer and anti-inflammatory activities. A study published in Nature Communications demonstrated that derivatives of this compound can inhibit key enzymes involved in tumor progression, highlighting its therapeutic potential.

In addition to its pharmaceutical applications, 4-Bromo-2-(methylsulphonyl)benzonitrile has found utility in materials science. Its electron-withdrawing groups make it an ideal candidate for use in organic electronics, particularly in the development of high-performance polymers and conductive materials. Recent research has focused on incorporating this compound into polymer frameworks to enhance their electrical conductivity and stability under harsh conditions.

The methylsulfonyl group in this compound plays a crucial role in modulating its reactivity and solubility properties. This functionality has been leveraged in various chemical transformations, including Suzuki-Miyaura couplings and other cross-coupling reactions. These reactions are pivotal in constructing complex molecular architectures with precision and efficiency.

From an environmental standpoint, the development of sustainable synthesis routes for 4-Bromo-2-(methylsulphonyl)benzonitrile is a priority for researchers. Green chemistry principles are being increasingly integrated into its production processes to minimize ecological impact while maintaining high yields and product quality.

In conclusion, 4-Bromo-2-(methylsulphonyl)benzonitrile stands as a testament to the ingenuity of modern chemical synthesis and its vast potential across diverse scientific domains. As research continues to uncover new applications and optimize existing processes, this compound is poised to play an even more significant role in advancing both medicine and materials science.

• 254887-17-7(4-Bromo-1-methyl-2-(methylsulfonyl)benzene)
• 254887-18-8(4-Bromo-1-(bromomethyl)-2-(methylsulfonyl)benzene)
• 648906-18-7(Benzene, 5-bromo-1,3-dimethyl-2-(methylsulfonyl)-)
• 99768-21-5(4-Bromo-1-methanesulfonyl-2-methylbenzene)
• 54737-49-4(Benzonitrile, 2-(phenylsulfonyl)-)
• 89942-56-3(2-(Methylsulfonyl)benzonitrile)
• 141763-00-0(Benzene, 1-bromo-2,4-dimethyl-5-(methylsulfonyl)-)
• 220364-32-9(5-(Bromomethyl)-2-(methylsulfonyl)benzonitrile)
• 118412-87-6(1,3-BENZENEDICARBONITRILE, 4-(METHYLSULFONYL)-)
• 5324-75-4(1-(benzenesulfonyl)-4-bromo-2-methylbenzene)