Cas no 1186310-66-6 ((2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol)

(2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol is a versatile pyridine derivative with significant utility in organic synthesis and pharmaceutical intermediates. Its key structural features—a chlorinated pyridine core, dimethoxymethyl group, and hydroxymethyl functionality—enable selective reactivity for further functionalization, making it valuable in constructing complex heterocyclic frameworks. The compound exhibits stability under standard conditions, facilitating handling and storage. Its balanced polarity ensures compatibility with a range of solvents, enhancing its applicability in cross-coupling reactions, nucleophilic substitutions, and other transformations. The presence of multiple reactive sites allows for tailored modifications, supporting its use in agrochemical, medicinal, and material science research. High purity grades are typically available to meet rigorous synthetic demands.
(2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol structure
1186310-66-6 structure
Product Name:(2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol
CAS No:1186310-66-6
MF:C9H12ClNO3
MW:217.649481773376
MDL:MFCD12922739
CID:1077724
PubChem ID:46737864
Update Time:2025-05-22

(2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol Chemical and Physical Properties

Names and Identifiers

    • (2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol
    • DB-353283
    • [2-chloro-3-(dimethoxymethyl)pyridin-4-yl]methanol
    • MFCD12922739
    • 1186310-66-6
    • (2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol, AldrichCPR
    • AKOS015851088
    • MDL: MFCD12922739
    • Inchi: 1S/C9H12ClNO3/c1-13-9(14-2)7-6(5-12)3-4-11-8(7)10/h3-4,9,12H,5H2,1-2H3
    • InChI Key: AETBLKFNUDOPSK-UHFFFAOYSA-N
    • SMILES: ClC1C(=C(C=CN=1)CO)C(OC)OC

Computed Properties

  • Exact Mass: 217.05100
  • Monoisotopic Mass: 217.0505709g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 4
  • Complexity: 166
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.6
  • Topological Polar Surface Area: 51.6?2

Experimental Properties

  • PSA: 51.58000
  • LogP: 1.51870

(2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol Security Information

  • HazardClass:IRRITANT

(2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol Customs Data

  • HS CODE:2933399090
  • Customs Data:

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Additional information on (2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol

Comprehensive Analysis of (2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol (CAS No. 1186310-66-6)

(2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol, with the CAS number 1186310-66-6, is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This compound belongs to the pyridine derivative family, characterized by its unique chloro and dimethoxymethyl functional groups. Researchers and industry professionals often search for pyridine derivatives, methanol-substituted compounds, and chloro-pyridine synthesis methods, reflecting its relevance in modern chemical applications.

The structural features of (2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol make it a valuable intermediate in the synthesis of complex molecules. Its methanol group provides a reactive site for further functionalization, while the dimethoxymethyl moiety enhances stability under various reaction conditions. Recent trends in green chemistry and sustainable synthesis have increased interest in such compounds, as they often serve as building blocks for environmentally friendly processes. Questions like "How to optimize the yield of (2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol?" or "Applications of chloro-pyridine derivatives in drug discovery" are frequently explored in academic and industrial forums.

From a synthetic perspective, CAS 1186310-66-6 is typically prepared through multi-step reactions involving halogenation, etherification, and hydroxylation. The compound's purity and yield are critical factors, especially for applications in high-value pharmaceuticals or crop protection agents. Analytical techniques such as HPLC, NMR, and mass spectrometry are commonly employed to characterize this compound, ensuring compliance with industry standards. Searches related to "spectroscopic data of (2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol" or "scalable synthesis routes" highlight the practical challenges researchers face.

The versatility of (2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol extends to its potential role in medicinal chemistry. Pyridine-based scaffolds are known for their bioactivity, and modifications like the chloro and methanol groups can influence pharmacokinetic properties. Current studies investigate its utility in designing kinase inhibitors or antimicrobial agents, aligning with the growing demand for novel therapeutics. Popular queries such as "Mechanism of action of pyridine methanol derivatives" or "Structure-activity relationship of chloro-substituted pyridines" underscore its scientific significance.

In the agrochemical sector, CAS 1186310-66-6 is explored for developing next-generation pesticides with improved efficacy and reduced environmental impact. The compound's structural motifs contribute to pest resistance management strategies, addressing global concerns about food security and sustainable agriculture. Discussions around "Pyridine derivatives in crop protection" or "Eco-friendly pesticide formulations" often reference such advanced intermediates.

Handling and storage of (2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol require adherence to standard laboratory protocols. While not classified as hazardous under normal conditions, proper ventilation, personal protective equipment (PPE), and chemical compatibility checks are recommended. Safety data sheets (SDS) for CAS 1186310-66-6 provide detailed guidance, and searches like "Storage conditions for pyridine methanol compounds" reflect user preparedness needs.

In conclusion, (2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol (1186310-66-6) represents a pivotal compound bridging multiple scientific disciplines. Its applications in drug development, material science, and agrochemical innovation continue to inspire research. As the scientific community prioritizes precision synthesis and functional diversity, this compound remains a subject of enduring interest and exploration.

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