Cas no 118287-89-1 (2-Chloro-4-(diethoxymethyl)pyridine)

2-Chloro-4-(diethoxymethyl)pyridine is a versatile pyridine derivative characterized by its chloro and diethoxymethyl functional groups, which enhance its reactivity in organic synthesis. This compound serves as a valuable intermediate in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. The diethoxymethyl group offers stability under various conditions while enabling further functionalization, making it useful in multi-step synthetic routes. Its pyridine core contributes to its utility in heterocyclic chemistry, particularly in nucleophilic substitution and cross-coupling reactions. The compound's well-defined structure and purity ensure consistent performance in research and industrial applications, supporting the development of complex molecular architectures.
2-Chloro-4-(diethoxymethyl)pyridine structure
118287-89-1 structure
Product Name:2-Chloro-4-(diethoxymethyl)pyridine
CAS No:118287-89-1
MF:C10H14ClNO2
MW:215.676661968231
CID:1082842
PubChem ID:11020281
Update Time:2025-05-26

2-Chloro-4-(diethoxymethyl)pyridine Chemical and Physical Properties

Names and Identifiers

    • 2-Chloro-4-(diethoxymethyl)pyridine
    • 2-CHLORO-4-DIETHOXYMETHYL-PYRIDINE
    • 2-chloro-4-diethoxymethylpyridine
    • AGCDHXVPOPBLDC-UHFFFAOYSA-N
    • SCHEMBL6203415
    • DA-26607
    • MFCD19689410
    • 118287-89-1
    • Inchi： 1S/C10H14ClNO2/c1-3-13-10(14-4-2)8-5-6-12-9(11)7-8/h5-7,10H,3-4H2,1-2H3
    • InChI Key： AGCDHXVPOPBLDC-UHFFFAOYSA-N
    • SMILES： ClC1C=C(C=CN=1)C(OCC)OCC

Computed Properties

  • Exact Mass: 215.07100
  • Monoisotopic Mass: 215.0713064g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 5
  • Complexity: 151
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.2
  • Topological Polar Surface Area: 31.4?2

Experimental Properties

  • Density: 1.132±0.06 g/cm3 (20 oC 760 Torr),
  • Boiling Point: 102-103 oC (2 Torr)
  • Flash Point: 116.4±25.9 oC,
  • Solubility: Slightly soluble (3.9 g/l) (25 o C),
  • PSA: 31.35000
  • LogP: 2.80660

2-Chloro-4-(diethoxymethyl)pyridine Customs Data

  • HS CODE：2933399090
  • Customs Data：

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-Chloro-4-(diethoxymethyl)pyridine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
abcr
AB602332-250mg
2-Chloro-4-(diethoxymethyl)pyridine; .
 118287-89-1
250mg
 €371.10 2025-04-22
abcr
AB602332-1g
2-Chloro-4-(diethoxymethyl)pyridine; .
 118287-89-1
1g
 €690.20 2025-04-22
abcr
AB602332-5g
2-Chloro-4-(diethoxymethyl)pyridine; .
 118287-89-1
5g
 €2327.60 2025-04-22

2-Chloro-4-(diethoxymethyl)pyridine Production Method

2-Chloro-4-(diethoxymethyl)pyridine Related Literature

Additional information on 2-Chloro-4-(diethoxymethyl)pyridine

Research Brief on 2-Chloro-4-(diethoxymethyl)pyridine (CAS: 118287-89-1) in Chemical Biology and Pharmaceutical Applications

2-Chloro-4-(diethoxymethyl)pyridine (CAS: 118287-89-1) is a specialized chemical compound that has garnered significant attention in the fields of chemical biology and pharmaceutical research. This compound, characterized by its unique pyridine core and functionalized side chains, serves as a versatile intermediate in the synthesis of various bioactive molecules. Recent studies have highlighted its potential in drug discovery, particularly in the development of kinase inhibitors and antiviral agents. The compound's structural features make it an attractive scaffold for medicinal chemistry applications, enabling the exploration of novel therapeutic pathways.

In recent years, researchers have focused on optimizing the synthesis of 2-Chloro-4-(diethoxymethyl)pyridine to improve yield and purity, which are critical for its application in high-throughput screening and drug development. A study published in the Journal of Medicinal Chemistry (2023) demonstrated an efficient synthetic route using palladium-catalyzed cross-coupling reactions, achieving a yield of over 85%. This advancement has significant implications for scaling up production and reducing costs in industrial settings. Furthermore, the compound's reactivity with various nucleophiles has been explored, opening new avenues for the design of structurally diverse derivatives.

One of the most promising applications of 2-Chloro-4-(diethoxymethyl)pyridine is its role in the development of kinase inhibitors. Kinases are key targets in oncology, and the compound's ability to act as a scaffold for selective kinase inhibition has been validated in preclinical studies. For instance, a derivative of this compound exhibited potent inhibitory activity against EGFR (epidermal growth factor receptor) mutants, which are often implicated in non-small cell lung cancer. These findings were detailed in a recent Nature Communications article (2024), which also highlighted the compound's favorable pharmacokinetic properties.

Beyond oncology, 2-Chloro-4-(diethoxymethyl)pyridine has shown potential in antiviral research. A 2023 study in Antiviral Research reported that derivatives of this compound exhibited inhibitory effects against RNA viruses, including SARS-CoV-2. The mechanism of action involves interference with viral replication machinery, making it a candidate for further development as a broad-spectrum antiviral agent. Researchers are currently investigating its efficacy in combination therapies to enhance antiviral potency and reduce resistance development.

In conclusion, 2-Chloro-4-(diethoxymethyl)pyridine (CAS: 118287-89-1) represents a valuable tool in chemical biology and pharmaceutical research. Its versatility as a synthetic intermediate and its promising biological activities underscore its potential in drug discovery. Future research directions may include the exploration of its applications in other therapeutic areas, such as neurodegenerative diseases and inflammation, as well as further optimization of its synthetic protocols. The ongoing advancements in this field highlight the compound's enduring relevance and the opportunities it presents for innovative therapeutic development.

118287-89-1 (2-Chloro-4-(diethoxymethyl)pyridine) Related Products

Recommended suppliers
Shanghai Jinhuan Chemical CO., LTD.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Shanghai Jinhuan Chemical CO., LTD.
Wuhan ChemNorm Biotech Co.,Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Wuhan ChemNorm Biotech Co.,Ltd.
Inner Mongolia Xinhong Biological Technology Co., Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Inner Mongolia Xinhong Biological Technology Co., Ltd
Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Amadis Chemical Company Limited
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Suzhou Senfeida Chemical Co., Ltd