Cas no 114873-05-1 (Boc-L-2-Methylphenylalanine)
Boc-L-2-Methylphenylalanine Chemical and Physical Properties
Names and Identifiers
-
- (S)-2-((tert-Butoxycarbonyl)amino)-3-(o-tolyl)propanoic acid
- BOC-Phe(2-Me)-OH
- BOC-2-methyl-L-phenylalanine
- tert-Butoxycarbonyl-L-2-methylphenylalanine
- Boc-2-Methy-L-Phenylalanine
- BOC-L-2-Methylphe
- Boc-L-2-Methylphenylalanine
- (2S)-3-(2-methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
- Boc-L-2-CH3-Phe
- BOC-O-ME-L-PHE-OH
- Boc-L-2-Me-Phe-OH
- BOC-L-PHE(2-ME)-OH
- RARECHEM BK PT 0056
- Boc-L-2-Methyl-phe-OH
- (S)-2-(tert-butoxycarbonylamino)-3-o-tolylpropanoic acid
- (2S)-2-(tert-butoxycarbonylamino)-3-(o-tolyl)propanoic acid
- (2S)-3-(2-methylphenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid
-
- MDL： MFCD00671390
- Inchi： 1S/C15H21NO4/c1-10-7-5-6-8-11(10)9-12(13(17)18)16-14(19)20-15(2,3)4/h5-8,12H,9H2,1-4H3,(H,16,19)(H,17,18)/t12-/m0/s1
- InChI Key： PCGOCPOJLMLJAR-LBPRGKRZSA-N
- SMILES： O(C(N[C@H](C(=O)O)CC1C=CC=CC=1C)=O)C(C)(C)C
Computed Properties
- Exact Mass: 279.14700
- Monoisotopic Mass: 279.147
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 20
- Rotatable Bond Count: 6
- Complexity: 348
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 1
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 75.6
Experimental Properties
- Density: 1.1400
- Melting Point: 113 oC
- Boiling Point: 442.5°Cat760mmHg
- Flash Point: 221.4°C
- Refractive Index: 1.526
- PSA: 75.63000
- LogP: 2.90630
- Specific Rotation: -16 o (c=1,MeOH)
Boc-L-2-Methylphenylalanine Security Information
- Signal Word：Warning
- Hazard Statement： H315; H319; H335
- Warning Statement： P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
-
Hazardous Material Identification：
- HazardClass：IRRITANT
- Storage Condition：Store at room temperature
Boc-L-2-Methylphenylalanine Customs Data
- HS CODE：2924299090
- Customs Data：
China Customs Code:
2924299090Overview:
2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to, packing
Summary:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Boc-L-2-Methylphenylalanine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| abcr | AB165596-250 mg |
Boc-L-2-Methylphenylalanine (Boc-L-Phe(2-Me)-OH); . |
114873-05-1 | 250mg |
€72.90 | 2023-06-23 | ||
| abcr | AB165596-1 g |
Boc-L-2-Methylphenylalanine (Boc-L-Phe(2-Me)-OH); . |
114873-05-1 | 1g |
€81.90 | 2023-06-23 | ||
| abcr | AB165596-5 g |
Boc-L-2-Methylphenylalanine (Boc-L-Phe(2-Me)-OH); . |
114873-05-1 | 5g |
€138.50 | 2023-06-23 | ||
| abcr | AB165596-10 g |
Boc-L-2-Methylphenylalanine (Boc-L-Phe(2-Me)-OH); . |
114873-05-1 | 10g |
€201.10 | 2023-06-23 | ||
| abcr | AB165596-25 g |
Boc-L-2-Methylphenylalanine (Boc-L-Phe(2-Me)-OH); . |
114873-05-1 | 25g |
€394.80 | 2023-06-23 | ||
| ChemScence | CS-W000802-5g |
(S)-2-((tert-butoxycarbonyl)amino)-3-(o-tolyl)propanoic acid |
114873-05-1 | 99.73% | 5g |
$73.0 | 2022-04-28 | |
| ChemScence | CS-W000802-10g |
(S)-2-((tert-butoxycarbonyl)amino)-3-(o-tolyl)propanoic acid |
114873-05-1 | 99.73% | 10g |
$133.0 | 2022-04-28 | |
| ChemScence | CS-W000802-25g |
(S)-2-((tert-butoxycarbonyl)amino)-3-(o-tolyl)propanoic acid |
114873-05-1 | 99.73% | 25g |
$314.0 | 2022-04-28 | |
| TRC | B657028-10mg |
Boc-L-2-Methylphenylalanine |
114873-05-1 | 10mg |
$ 50.00 | 2022-06-07 | ||
| TRC | B657028-50mg |
Boc-L-2-Methylphenylalanine |
114873-05-1 | 50mg |
$ 65.00 | 2022-06-07 |
Boc-L-2-Methylphenylalanine Suppliers
Audited Supplier
Boc-L-2-Methylphenylalanine Related Literature
-
Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
-
Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
-
Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
Additional information on Boc-L-2-Methylphenylalanine
Recent Advances in the Application of Boc-L-2-Methylphenylalanine (CAS: 114873-05-1) in Chemical Biology and Pharmaceutical Research
Boc-L-2-Methylphenylalanine (CAS: 114873-05-1) is a protected amino acid derivative that has garnered significant attention in chemical biology and pharmaceutical research due to its unique structural properties and versatile applications. This compound, characterized by the presence of a tert-butoxycarbonyl (Boc) protecting group and a 2-methylphenyl side chain, serves as a crucial building block in peptide synthesis and drug development. Recent studies have explored its potential in modulating protein-protein interactions, enhancing peptide stability, and serving as a precursor for novel therapeutic agents.
One of the key areas of research involving Boc-L-2-Methylphenylalanine is its role in the synthesis of peptide-based therapeutics. The Boc group provides stability during solid-phase peptide synthesis (SPPS), while the 2-methylphenyl side chain contributes to the hydrophobic interactions essential for binding to target proteins. A 2023 study published in the Journal of Medicinal Chemistry demonstrated the efficacy of Boc-L-2-Methylphenylalanine in the design of protease-resistant peptides, highlighting its potential in developing orally bioavailable peptide drugs.
In addition to its applications in peptide synthesis, Boc-L-2-Methylphenylalanine has been investigated for its role in small-molecule drug discovery. Researchers have utilized this compound as a chiral auxiliary in asymmetric synthesis, enabling the production of enantiomerically pure intermediates for pharmaceuticals. A recent publication in Organic Letters (2024) detailed a novel catalytic system that employs Boc-L-2-Methylphenylalanine to achieve high enantioselectivity in the synthesis of β-amino acids, a class of compounds with broad therapeutic potential.
Furthermore, the compound's unique structural features have made it a valuable tool in chemical biology studies. For instance, a 2023 study in ACS Chemical Biology reported the use of Boc-L-2-Methylphenylalanine as a probe to investigate enzyme-substrate interactions in phenylalanine-metabolizing enzymes. The methyl group at the 2-position of the phenyl ring was found to significantly alter the binding affinity and catalytic efficiency of these enzymes, providing insights into enzyme engineering and inhibitor design.
Recent advancements in analytical techniques have also facilitated a deeper understanding of Boc-L-2-Methylphenylalanine's properties. High-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) spectroscopy have been employed to characterize its conformational dynamics and intermolecular interactions. These studies, published in Analytical Chemistry (2024), have revealed the compound's propensity to form stable intramolecular hydrogen bonds, which may explain its enhanced stability in biological systems.
Looking ahead, the application of Boc-L-2-Methylphenylalanine is expected to expand into emerging areas such as targeted drug delivery and bioorthogonal chemistry. Preliminary results from ongoing research suggest that modifications of the Boc group could enable site-specific conjugation to nanoparticles and antibodies, opening new avenues for precision medicine. As the field continues to evolve, Boc-L-2-Methylphenylalanine (CAS: 114873-05-1) remains a compound of significant interest for researchers seeking to bridge the gap between chemical synthesis and biological application.
114873-05-1 (Boc-L-2-Methylphenylalanine) Related Products
- 80102-27-8((R)-2-((tert-butoxycarbonyl)amino)-3-(p-tolyl)propanoic acid)
- 100564-78-1(N-Boc-L-homophenylalanine)
- 37553-65-4(Boc-N-Me-Phe-OH)
- 13734-34-4((2S)-2-(tert-butoxycarbonylamino)-3-phenyl-propanoic acid)
- 76985-10-9((R)-2-((tert-Butoxycarbonyl)amino)-3-(naphthalen-2-yl)propanoic acid)
- 55533-24-9((S)-3-(4-Aminophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid)
- 70642-86-3(Boc-D-Tyr-OH)
- 18942-49-9(Boc-D-Phe-OH)
- 51987-73-6(N-Boc-L-phenylalanine methyl ester)
- 3978-80-1(N-Boc-L-tyrosine)
