• 1. Diversity oriented synthesis of 6-nitro- and 6-aminoquinolones and their activity as alkaline phosphatase inhibitors
  Mariia Miliutina,Anton Ivanov,Syeda Abida Ejaz,Jamshed Iqbal,Alexander Villinger,Viktor O. Iaroshenko,Peter Langer RSC Adv. 2015 5 60054
• 2. Photoredox halogenation of quinolones: the dual role of halo-fluorescein dyes
  Ritu,Sharvan Kumar,Parul Chauhan,Nidhi Jain Org. Biomol. Chem. 2021 19 4585
• 3. Production of 3- benzoyl-2,1-benzisoxazoles,2-phenyl-4H-3,1-benzoxazin-4-ones, and novel quinolinone derivatives from 2-phenylquinolin-4(1H)-ones and sodium dichloroisocyanurate
  Benjamin Staskun,Theodorus van Es J. Chem. Soc. Perkin Trans. 1 1993 511
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• 5. Facile synthesis of antimalarial 1,2-disubstituted 4-quinolones from 1,3-bisaryl-monothio-1,3-diketones
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Phenylquinolines

4-Hydroxy-2-phenylquinoline (CAS 1144-20-3): Properties, Applications, and Market Insights

4-Hydroxy-2-phenylquinoline (CAS 1144-20-3) is a versatile organic compound with a wide range of applications in pharmaceuticals, materials science, and chemical research. This heterocyclic compound features a quinoline backbone substituted with a hydroxyl group at the 4-position and a phenyl group at the 2-position, giving it unique chemical and physical properties. Researchers and industries are increasingly interested in 4-Hydroxy-2-phenylquinoline derivatives due to their potential in drug development and advanced material synthesis.

The molecular structure of 4-Hydroxy-2-phenylquinoline contributes to its fluorescence properties, making it valuable in optical materials and sensor technologies. Recent studies highlight its role in developing organic light-emitting diodes (OLEDs) and bioimaging probes, aligning with the growing demand for sustainable and efficient materials in electronics and healthcare. The compound's chelating ability also makes it useful in coordination chemistry, particularly in designing metal-organic frameworks (MOFs).

In the pharmaceutical sector, 4-Hydroxy-2-phenylquinoline serves as a key intermediate for synthesizing bioactive molecules. Its structural motif appears in several drug candidates with potential anti-inflammatory, antimicrobial, and anticancer activities. Researchers are exploring its derivatives for targeted drug delivery systems, responding to the global focus on personalized medicine and precision therapeutics.

The synthesis of 4-Hydroxy-2-phenylquinoline typically involves cyclization reactions of appropriate precursors, with recent advancements focusing on green chemistry approaches to improve yield and reduce environmental impact. This aligns with the chemical industry's shift toward sustainable synthesis methods and green manufacturing processes, addressing concerns about carbon footprint reduction in chemical production.

Market analysis indicates growing demand for 4-Hydroxy-2-phenylquinoline across multiple industries. The pharmaceutical intermediates market is expected to drive significant consumption, particularly in Asia-Pacific regions where drug discovery research is expanding rapidly. Additionally, the electronic materials sector presents new opportunities as manufacturers seek high-performance organic semiconductors for next-generation devices.

Quality control and characterization of 4-Hydroxy-2-phenylquinoline involve advanced analytical techniques such as HPLC, mass spectrometry, and NMR spectroscopy. These methods ensure product purity and consistency, which are critical for research and industrial applications. Recent developments in analytical chemistry have improved detection limits and reduced analysis time for this compound and its derivatives.

Storage and handling of 4-Hydroxy-2-phenylquinoline require standard laboratory precautions. The compound should be kept in airtight containers away from light and moisture to maintain stability. While not classified as hazardous under normal conditions, proper personal protective equipment is recommended when handling the powder form to avoid inhalation or contact with eyes and skin.

Future research directions for 4-Hydroxy-2-phenylquinoline include exploring its potential in energy storage applications and developing more efficient catalytic systems for its production. The compound's versatility continues to attract attention from both academic and industrial researchers, particularly in fields related to renewable energy and smart materials.

For researchers seeking 4-Hydroxy-2-phenylquinoline suppliers, it's important to verify CAS 1144-20-3 purity specifications and request comprehensive analytical certificates. Many manufacturers now offer custom synthesis services for specialized derivatives, catering to the growing need for tailor-made chemical building blocks in advanced research projects.

• 219850-90-5(Quinoline, 4-methoxy-2-(4-methylphenyl)-)
• 40756-70-5(Phenol,3-(1H-indol-2-yl)-)
• 62613-58-5(1H-Indol-6-ol, 2-phenyl-)
• 87741-95-5(2-Phenylquinolin-7-ol)
• 87741-94-4(2-Phenylquinolin-6-ol)
• 6337-51-5(4-Quinolinol,2-(4-chlorophenyl)-)
• 22680-65-5(Quinoline,4,6-dimethoxy-2-phenyl-)
• 698984-37-1(2-Phenylquinolin-5-ol)
• 144709-03-5(Quinoline, 4-methoxy-2-(4-methoxyphenyl)-)
• 21286-73-7(4-Quinolinol, 2-(4-methoxyphenyl)-)